Results 91 to 100 of about 2,290 (178)

Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract Small extracellular vesicles (sEVs) are cell‐derived vesicles evolving as important elements involved in all stages of cancers. sEVs bear unique protein signatures that may serve as biomarkers. Pancreatic cancer (PC) records a very poor survival rate owing to its late diagnosis and several cancer cell‐derived proteins have been reported as ...
Chamini J. Perera, SM Zahid Hosen, Tanzila Khan, Haoyun Fang, Alpha Raj Mekapogu, Zhihong Xu, Marco Falasca, Suresh T. Chari, Jeremy S. Wilson, Ron Pirola, David W. Greening, Minoti V. Apte   +11 more
wiley   +1 more source

Identification of claudin-4 as a marker highly overexpressed in both primary and metastatic prostate cancer [PDF]

, 2008
In the quest for markers of expression and progression for prostate cancer (PCa), the majority of studies have focussed on molecular data exclusively from primary tumours.
A Fusi, AD Santin, AM Tokes, B Scells, BF Hankey, C Rahner, C Stephan, CS Foster, D Hanahan, D Hessels, DG Bostwick, DG Bostwick, DK Ornstein, DS Smith, GM Sheehan, H Honda, H Liu, H Long, H Samaratunga, HJ Sommerfeld, J Katahira, J Katahira, J Massague, J Yang, JS Ross, K A Landers, K Morita, K Morita, KA Landers, L Bubendorf, L Teng, LB Rangel, LS Nichols, M Buck, M F Lavin, M J Burger, M Matsuda, MA Rubin, MJ Burger, N Sato, O Hameed, P Michl, P Michl, P Wikstrom, R A Gardiner, R Agarwal, R Montironi, RF Hoedemaeker, RL Stark, RS Weinstein, S Boireau, SJ Freedland, SK Lee, SL Kominsky, SS Chang, TA Martin, Z Jiang   +56 more
core   +2 more sources

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index

Clinical and Translational Medicine, Volume 14, Issue 2, February 2024.
AIDPI is a robust biomarker for stratifying high‐risk OSA patients characterized by dysregulated cholesterol homeostasis, and SQLE is a metabolic vulnerability of these patients. Silencing SQLE impedes OSA by reducing cholesterol and inhibiting the FAK/PI3K/Akt/mTOR pathway.
Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang   +7 more
wiley   +1 more source

Generation and characterisation of two D2A1 mammary cancer sublines to model spontaneous and experimental metastasis in a syngeneic BALB/c host [PDF]

, 2017
Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system.
Aslakson, Bos, Bouchard, Bruna, Byrne, Chen, Eckhardt, Fantozzi, Francia, Frisch, Guy, Guy, Hanahan, Harney, Holen, Hunter, Janik, Johnstone, Khanna, Lelekakis, Lockman, Mahoney, Miller, Morris, Neve, O'Reilly, Paoli, Shibue, Tester, Viski, Xian, Yang, Yang, Yang, Zhang   +34 more
core   +3 more sources

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research [PDF]

, 2014
Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses
Chaim, Isaac Alexander, Nagel, Zachary D., Samson, Leona D   +2 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Proteomic analysis of human oral verrucous carcinoma [PDF]

, 2013
This study is about proteomic analysis of oral verrucous carcinoma (OVC). The total proteins obtained from tumour and adjacent normal oral mucosa of patients with OVC and oral squamous cell carcinoma (OSCC) were separated with two dimensional ...
Chen, Y, Li, G, Liu, C, Qu, B, Tang, Z, Wang, Y, Xiao, Z, Xie, X, Yao, Z, Zhao, S   +9 more
core   +2 more sources

Tumor protein D52 (TPD52): A novel B-cell/plasma-cell molecule with unique expression pattern and Ca2+-dependent association with annexin VI [PDF]

, 2005
We generated a murine monoclonal antibody (B28p) detecting an antigenic determinant shared by the immunoglobulin superfamily receptor translocation-associated 1 (IRTA1) receptor (the immunogen used to raise B28p) and an unrelated 28-kDa protein that was ...
A. Carbone, A. Liso, A. Pucciarini, A. Scherl, B. Bigerna, B. Falini, C. Pasquarello, E. Tiacci, G. Alunni-Bistocchi, G.L. Corthals, H. Robertson, J.A. Byrne, K. Pulford, L. Binaglia, M. Gambacorta, M.P. Martelli, M.T. Sciurpi, N. Bolli, P. Orvietani, R. Benedetti, R. Pacini, S. Pileri, V. Pettirossi   +22 more
core   +1 more source

Long-Noncoding RNA FGD5-AS1 Enhances the Viability, Migration, and Invasion of Glioblastoma Cells by Regulating the miR-103a-3p/TPD52 Axis

Cancer Management and Research, 2020
Daoqing Su, Zhengang Ji, Pengfei Xue, Shengfu Guo, Qingbin Jia, Hanyu Sun Department of Neurosurgery, Liaocheng People’s Hospital and Liaocheng Brain Hospital, Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng City ...
Su D, Ji Z, Xue P, Guo S, Jia Q, Sun H
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