Results 11 to 20 of about 1,428 (171)

The Tumor Suppressor TPD52‐Governed Endoplasmic Reticulum Stress is Modulated by APCCdc20 [PDF]

Advanced Science
Aberrant regulation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress pathway is associated with cancer development, metastasis, and relapse, and the UPR signal transducer ATF6 has been proposed as a diagnostic and prognostic marker ...
Weichao Dan, Lei Li
exaly   +7 more sources

Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma [PDF]

Scientific Reports
Prostate cancer (PCa) ranks among the most prevalent malignant tumors worldwide. The pivotal role of competitive endogenous RNA (ceRNA) regulatory networks in numerous cancer types has been underscored.
Zhi Shang, Shengming Jin, Yandong He, Yiping Zhu, Hailiang Zhang, Junlong Wu, Zhe Hong, Dingwei Ye   +7 more
doaj   +5 more sources

Tumor protein D52 ( TPD52 ) affects cancer cell metabolism by negatively regulating AMPK

Cancer Medicine, 2023
Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. However, how this pathway is dysregulated in cancer has not been well clarified.
Jia Yu, Zhenkun Lou, Huadong Pei
exaly   +3 more sources

TPD52 promotes the proliferation and metastasis of gastric cancer cells [PDF]

BMC Gastroenterology
Immunotherapy has improved outcomes for tumor patients, but only a small proportion benefits due to genetic and immunological resistance. Enhancing its efficacy is crucial.
Shunhao Zhang, Zhixin Geng, Jian Sun, Nan Chen, Man Liu, Yuting Wang, Xinliang Gu, Bing Pei   +7 more
doaj   +5 more sources

Preclinical support for tumor protein D52 as a cancer vaccine antigen [PDF]

Human Vaccines & Immunotherapeutics, 2023
Overexpressed tumor-associated antigens (TAAs) are a large group that includes proteins found at increased levels in tumors compared to healthy cells. Universal tumor expression can be defined as overexpression in all cancers examined as has been shown ...
Robert K. Bright
doaj   +3 more sources

KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis [PDF]

Cancer Biology & Therapy
In this study, we aimed to investigate the molecular mechanism of Krüppel-like factor 7 (KLF7) in colorectal cancer (CRC) cell invasion and migration. The expression pattern of KLF7 in CRC tissues and the correlation between KLF7 expression and clinical ...
Juan Zhang, Zhihan Li, Jiaxu Han, Zhongtao Tian, Qingyu Meng, Wenbo Niu   +5 more
doaj   +3 more sources

PANoptosis-Related Diagnostic Biomarkers in Non-Neovascular Age-Related Macular Degeneration: An Integrative Transcriptomic and Experimental Study [PDF]

Genetics Research
Age-related macular degeneration (AMD), particularly its non-neovascular (dry) form, is a progressive retinal disorder that causes central vision loss and substantial impairment in daily life.
Jiaming Li, Yirong Ma, Miao Hu, Qian Zhang, Anqi Wang, Qiuyu Tang, Qinshang Guo, Binglin Huang   +7 more
doaj   +3 more sources

Decoding the Tumor Microenvironment of Myoepithelial Cells in Triple-Negative Breast Cancer Through Single-Cell and Transcriptomic Sequencing and Establishing a Prognostic Model Based on Key Myoepithelial Cell Genes [PDF]

International Journal of Genomics
Conclusion: This study highlights MECs’ role in TNBC progression, provides a CoxBoost prognostic model for personalized treatment, and identifies TPD52 as a potential therapeutic target for TNBC intervention.
Xiaocheng Yu, Ye Tian, Rui Zhang, Yong Yang   +3 more
doaj   +3 more sources

Tumor Protein D53 (TPD53): Involvement in Malignant Transformation of Low-Malignant Oral Squamous Cell Carcinoma Cells [PDF]

Biomedicines
Background/Objectives: The tumor protein D52 (TPD52) family includes TPD52, TPD53, TPD54, and TPD55. The balance between TPD52 and TPD54 expression plays an important role in high-malignant oral squamous cell carcinoma (OSCC) cells.
Masataka Watanabe, Yoshiki Mukudai, Nodoka Kindaichi, Maki Nara, Konomi Yamada, Yuzo Abe, Asami Houri, Toshikazu Shimane, Tatsuo Shirota   +8 more
doaj   +3 more sources

Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

Tumor Biology, 2016
The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage.
Simone Venz, Heike Junker, Uwe Zimmermann   +2 more
exaly   +5 more sources