PANoptosis-Related Diagnostic Biomarkers in Non-Neovascular Age-Related Macular Degeneration: An Integrative Transcriptomic and Experimental Study [PDF]
Genetics ResearchAge-related macular degeneration (AMD), particularly its non-neovascular (dry) form, is a progressive retinal disorder that causes central vision loss and substantial impairment in daily life.
Jiaming Li +7 more
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Decoding the Tumor Microenvironment of Myoepithelial Cells in Triple-Negative Breast Cancer Through Single-Cell and Transcriptomic Sequencing and Establishing a Prognostic Model Based on Key Myoepithelial Cell Genes [PDF]
International Journal of GenomicsConclusion: This study highlights MECs’ role in TNBC progression, provides a CoxBoost prognostic model for personalized treatment, and identifies TPD52 as a potential therapeutic target for TNBC intervention.
Xiaocheng Yu +3 more
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TPD52 as a Therapeutic Target Identified by Machine Learning Shapes the Immune Microenvironment in Breast Cancer. [PDF]
J Cell Mol MedABSTRACTBreast cancer (BRCA) is one of the most common malignancies and a leading cause of cancer‐related mortality among women globally. Despite advances in diagnosis and treatment, the heterogeneity of BRCA presents significant challenges for effective management and prognosis. Recent studies emphasise the critical role of the tumour microenvironment,
Xia J, Zhou X.
europepmc +4 more sources
Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis [PDF]
Parasites & Vectors, 2021 Background Trichinella spiralis (T. spiralis) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the antitumour effects of cross antigens between the tumour and T.
Tao-Tao Yue +10 more
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Hsa_circ_0007637 Facilitates Nasopharyngeal Carcinoma Progression by Sponging miR-636/TPD52 Axis
Cancer Management and Research, 2021 Yihong Wang,* Manyi Li,* Chen Pan,* Haiping Huang, Xiaoqing Hu, Jisheng Liu Department of Otolaryngology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this ...
Wang Y +5 more
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Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis [PDF]
Discover OncologyBackground Breast cancer is one of the most common causes of fatalities in females globally. Rising cases of drug resistance against existing chemotherapeutics are great problem.
Hania Shah +9 more
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Circular RNA circEZH2 Promotes Lung Adenocarcinoma Progression by Regulating microRNA-495-3p/Tumor Protein D52 Axis and Activating Nuclear Factor-Kappa B Pathway [PDF]
International Journal of General MedicineLiping Chen,1 Tongwei Xiang,2 Jing Xing,2 Xinan Lu,2 Shan Wei,2 Huaying Wang,2 Jipeng Li,1 Wanjun Yu2 1Department of Central Laboratory, The Affiliated People’s Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Department of Respiratory
Chen L +7 more
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MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women [PDF]
Frontiers in GeneticsIntroductionThe identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs.MethodsThe authors searched for ...
Bulat Yalaev +9 more
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Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancer [PDF]
BMC Genomics, 2023 Background Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers.
Chenxi Zhang +6 more
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Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway [PDF]
Cells, 2020 Breast cancer is the second greatest cause of cancer-related death in women. Resistance to endocrine treatments or chemotherapy is a limiting drawback.
Matteo Brindisi +5 more
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