Results 11 to 20 of about 1,427 (143)

KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis [PDF]

Cancer Biology & Therapy
In this study, we aimed to investigate the molecular mechanism of Krüppel-like factor 7 (KLF7) in colorectal cancer (CRC) cell invasion and migration. The expression pattern of KLF7 in CRC tissues and the correlation between KLF7 expression and clinical ...
Juan Zhang, Zhihan Li, Jiaxu Han, Zhongtao Tian, Qingyu Meng, Wenbo Niu   +5 more
doaj   +3 more sources

Tumor Protein D53 (TPD53): Involvement in Malignant Transformation of Low-Malignant Oral Squamous Cell Carcinoma Cells [PDF]

Biomedicines
Background/Objectives: The tumor protein D52 (TPD52) family includes TPD52, TPD53, TPD54, and TPD55. The balance between TPD52 and TPD54 expression plays an important role in high-malignant oral squamous cell carcinoma (OSCC) cells.
Masataka Watanabe, Yoshiki Mukudai, Nodoka Kindaichi, Maki Nara, Konomi Yamada, Yuzo Abe, Asami Houri, Toshikazu Shimane, Tatsuo Shirota   +8 more
doaj   +3 more sources

The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) are highly expressed in colorectal cancer and correlated with poor prognosis. [PDF]

PLoS ONE, 2017
The four-transmembrane protein MAL2 and tumor protein D52 (TPD52) have been shown to be involved in tumorigenesis of various cancers. However, their roles in colorectal cancer (CRC) remain unclear.
Jingwen Li, Yongmin Li, He Liu, Yanlong Liu, Binbin Cui   +4 more
doaj   +2 more sources

Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers

Scientific Reports, 2021
Maytenus roylanus (MEM) is a plant with anti-proliferative effects against prostate cancer. We aimed to explore the mechanism of action of MEM in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various
Maria Shabbir, Hasan Mukhtar, Deeba Syed, Suhail Razak, Tayyaba Afsar, Ali Almajwal, Yasmin Badshah, Dara Aldisi   +7 more
doaj   +2 more sources

MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

BMC Cancer, 2010
Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12.
Fanayan Susan, Scurry James P, Murali Rajmohan, Gloss Brian S, Hardy Jayne R, Maleki Sanaz, Byrne Jennifer A, Emmanuel Catherine, Hacker Neville F, Sutherland Robert L, deFazio Anna, O'Brien Philippa M   +11 more
doaj   +2 more sources

Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-κB transactivation in LNCaP cells

Tumor Biology, 2017
Our previous study showed that TPD52 overexpression could increase migration and proliferation of LNCaP cells contributing to the development of prostate cancer.
Chandrashekhar Dasari, Dattu Prasad Yaghnam, Reinhard Walther, Ramesh Ummanni   +3 more
doaj   +2 more sources

Urinary proteomic profiling reveals diagnostic biomarkers and regulatory networks in myasthenia gravis [PDF]

BMC Neurology
Background Myasthenia gravis (MG) is a chronic autoimmune neuromuscular junction disorder mediated by autoantibodies. Existing diagnostic methods mainly rely on serum antibody detection and electrophysiological testing, which are limited by invasiveness ...
Jing Yang, Xi Yang, Zhen-kun Zhu, Liang Shen, Shi-ge San, Lianchen Xiao, Fan Ye, Chun-hua Wang, Kun Meng   +8 more
doaj   +2 more sources

miR-107 enhances the sensitivity of breast cancer cells to paclitaxel

Open Medicine, 2019
Breast cancer remains the most commonly diagnosed cancer in Chinese women. Paclitaxel (PTX) is a chemotherapy medication used to treat breast cancer patients. However, a side effect of paclitaxel is the severe drug resistance.
Ma Changpo, Shi Xuejun, Guo Wenchao, Niu Jianxin, Wang Guangshun   +4 more
doaj   +2 more sources

Non-Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials. [PDF]

Cell Prolif
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Zhao X, Qiu Y, Chen J, Wang D, Wang Z, Ma S, Liu Y, Liu G, Bi Z.   +8 more
europepmc   +2 more sources

Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis [PDF]

Discover Oncology
Background Breast cancer is one of the most common causes of fatalities in females globally. Rising cases of drug resistance against existing chemotherapeutics are great problem.
Hania Shah, Khushbukhat Khan, Yasmin Badshah, Janeen H. Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Dara Aldisi, Dilawer Khan, Suhail Razak   +9 more
doaj   +2 more sources