Results 31 to 40 of about 1,428 (171)

miR-107 enhances the sensitivity of breast cancer cells to paclitaxel

Open Medicine, 2019
Breast cancer remains the most commonly diagnosed cancer in Chinese women. Paclitaxel (PTX) is a chemotherapy medication used to treat breast cancer patients. However, a side effect of paclitaxel is the severe drug resistance.
Ma Changpo, Shi Xuejun, Guo Wenchao, Niu Jianxin, Wang Guangshun   +4 more
doaj   +2 more sources

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials [PDF]

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +2 more sources

Nonredundant Functions for Tumor Protein D52-Like Proteins Support Specific Targeting of TPD52 [PDF]

Clinical Cancer Research, 2008
Abstract Purpose: Tumor protein D52 (TPD52 or D52) is frequently overexpressed in breast and other cancers and present at increased gene copy number. It is, however, unclear whether D52 amplification and overexpression target specific functional properties of the encoded protein.
Shehata, M., Bièche, I., Boutros, R., Weidenhofer, J., Fanayan, S., Spalding, L., Zeps, Nikolajs, Byth, K., Bright, R., Lidereau, R., Byrne, J.   +10 more
openaire   +4 more sources

miR-103a-3p Suppresses Cell Proliferation and Invasion by Targeting Tumor Protein D52 in Prostate Cancer

Journal of Investigative Surgery, 2021
Growing evidence points at an association between microRNAs and tumor development. Although dysregulation of microRNA-103a-3p (miR-103a-3p) in multiple human cancers has been reported, its expression in prostate cancer (PCa) remains unknown and there is ...
Jiyue Ge, Likai Mao, Weiqiang Xu, Wenge Fang, Ningning Wang, Dawen Ye, Zhuang Dong, Han Guan, Chao Guan   +8 more
doaj   +2 more sources

Urinary proteomic profiling reveals diagnostic biomarkers and regulatory networks in myasthenia gravis [PDF]

BMC Neurology
Background Myasthenia gravis (MG) is a chronic autoimmune neuromuscular junction disorder mediated by autoantibodies. Existing diagnostic methods mainly rely on serum antibody detection and electrophysiological testing, which are limited by invasiveness ...
Jing Yang, Xi Yang, Zhen-kun Zhu, Liang Shen, Shi-ge San, Lianchen Xiao, Fan Ye, Chun-hua Wang, Kun Meng   +8 more
doaj   +2 more sources

Hsa_circ_0084927 Regulates Cervical Cancer Advancement via Regulation of the miR-634/TPD52 Axis

Cancer Management and Research, 2020
Peijing Shi,1 Xiaoyong Zhang,1 Chunxiang Lou,1 Yunxia Xue,1 Ruibao Guo,1 Shuzhen Chen2 1Department of Gynaecology, The Third Hospital of Ji’nan, Jinan, People’s Republic of China; 2Department of Pathology, The Third Hospital of Ji’nan ...
Shi P, Zhang X, Lou C, Xue Y, Guo R, Chen S   +5 more
doaj   +4 more sources

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening [PDF]

Molecular Biology Reports, 2014
Tumor protein D52 (TPD52) is overexpressed in different cancers, but its molecular functions are poorly defined. A large, low-stringency yeast two-hybrid screen using full-length TPD52 bait identified known partners (TPD52, TPD52L1, TPD52L2, MAL2) and four other preys that reproducibly bound TPD52 and TPD52L1 baits (PLP2, RAB5C, GOLGA5, YIF1A).
Brian J Smith, Guy E Groblewski, Yuyan Chen   +2 more
exaly   +3 more sources

Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer

Autophagy, 2021
Aberrant chaperone-mediated autophagy (CMA) activation has been suggested as a tumorigenesis-promoting event in various cancers, although its roles in prostate cancer (PCa) remain elusive. Emerging evidence indicates that TPD52 isoform 1, a prostate-specific and androgen-responsive gene, contributes to the malignant progression of PCa.
Yizeng Fan, Tao Hou, Weichao Dan
exaly   +3 more sources

Identification of lncRNA, miRNA and mRNA expression profiles and ceRNA Networks in small cell lung cancer [PDF]

BMC Genomics, 2023
Background Small cell lung cancer (SCLC) is a highly lethal malignant tumor. It accounts for approximately 15% of newly diagnosed lung cancers.
Chenxi Zhang, Ying Zhou, Bin Zhang, Zhihong Sheng, Nan Sun, Baiyin Yuan, Xiaoyuan Wu   +6 more
doaj   +2 more sources

MiR-139-5p Inhibits the Development of Gastric Cancer through Targeting TPD52 [PDF]

Journal of Healthcare Engineering, 2022
Background. Many researchers have confirmed that miRNAs are involved in the pathogenesis of gastric cancer (GC). This study focused on investigating the specific functions of miR-139-5p in GC. Methods. MiR-139-5p and TPD52 expressions were observed by qRT-PCR or western blot in GC.
Yuanbo Li, Yan Sun, Zhenlu Li, Shikuan Li, Changliang Wu   +4 more
openaire   +2 more sources