Results 41 to 50 of about 1,612 (113)

HB‐EGF‐loaded nanovesicles enhance trophectodermal spheroid attachment and invasion

PROTEOMICS, Volume 24, Issue 11, June 2024.
Abstract The ability of trophectodermal cells (outer layer of the embryo) to attach to the endometrial cells and subsequently invade the underlying matrix are critical stages of embryo implantation during successful pregnancy establishment. Extracellular vesicles (EVs) have been implicated in embryo‐maternal crosstalk, capable of reprogramming ...
Qi Hui Poh, Alin Rai, Jonathon Cross, David W. Greening   +3 more
wiley   +1 more source

Pathway discovery using transcriptomic profiles in adult-onset severe asthma [PDF]

, 2018
Rationale Adult-onset severe asthma is characterized by highly symptomatic disease despite high intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease needed for the development of targeted treatments.
Adcock, IM, Auffray, C, Bansal, A, Baribaud, F, Bates, S, Bel, EH, Brinkman, P, Chung, KF, Corfield, J, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, SJ, Guo, Y, Hekking, PP, Howarth, P, Lefaudeux, D, Loza, MJ, Lutter, I, Meiser, A, Pandis, Y, Pavlidis, S, Shaw, DE, Sousa, A, Sterk, PJ, Sun, K, U-BIOPRED Study Group, Wagener, A   +27 more
core   +1 more source

Analysis of 206 whole‐genome resequencing reveals selection signatures associated with breed‐specific traits in Hu sheep

Evolutionary Applications, Volume 17, Issue 6, June 2024.
Abstract As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selection. Identifying selection signatures in Hu sheep can provide a straightforward insight into the mechanism
Fuping Zhao, Rui Xie, Lingzhao Fang, Ruidong Xiang, Zehu Yuan, Yang Liu, Lixian Wang   +6 more
wiley   +1 more source

Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc

Journal of Oncology, Volume 2024, Issue 1, 2024.
Zinc dyshomeostasis is manifested in breast and prostate cancer cells. This study attempted to uncover the molecular details prodded by the change of extracellular zinc by employing a panel of normal and cancerous breast and prostate cell lines coupled with the top‐down proteomics with two‐dimensional gel electrophoresis followed by liquid ...
Shital K. Barman, Monokesh K. Sen, David A. Mahns, Ming J. Wu, Chandra S. Malladi, Yuan Seng Wu   +5 more
wiley   +1 more source

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats

Journal of Animal Science and Biotechnology
Background Convergent evolution offers a unique lens through which to explore the molecular underpinnings of significant phenotypic transformations.
Zhanerke Akhatayeva, Yilong Shi, Kairat Dossybayev, Nurlan Malmakov, Hairong Cheng, Narantuya Baatar, Ji Yang, Menghua Li, Kejian Lin, Songsong Xu   +9 more
doaj   +1 more source

High-Throughput Proteomics Detection of Novel Splice Isoforms in Human Platelets [PDF]

, 2009
Alternative splicing (AS) is an intrinsic regulatory mechanism of all metazoans. Recent findings suggest that 100% of multiexonic human genes give rise to splice isoforms.
A Keller, AJ Atkinson, Andreas de Stefani, B Bodenmiller, B Modrek, BJ Blencowe, BP Lewis, C Sugnet, Cathal Seoighe, D Brett, DB Constam, E Durr, E Kim, ET Wang, F Clark, F Mo, GS Wang, H Liu, H Schwertz, H Yu, J Marioni, J Mestres, James P. McRedmond, JK Eng, JP McRedmond, Karen A. Power, M Matarin, M Sultan, MC Ozelo, ML Tress, ML Tress, MM Denis, O Holtkotter, P Censarek, P Harrison, P Mallick, P Rustin, Peadar Ó Gaora, PJ Kersey, R Sorek, S Draghici, S Mathivanan, S Stamm, S Tanner, SA Newland, SA Santoro, TA Thanaraj, TJP Hubbard, William M. Gallagher   +48 more
core   +9 more sources

Unintended perturbation of protein function using GFP nanobodies in human cells [PDF]

, 2019
Tagging a protein of interest with GFP using genome editing is a popular approach to study protein function in cell and developmental biology. To avoid re-engineering cell lines or organisms in order to introduce additional tags, functionalized ...
Clarke, Nicholas I., Küey, Cansu, Larocque, Gabrielle, Royle, Stephen J.   +3 more
core   +1 more source

Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms [PDF]

, 2005
Alternative splicing is widespread in the human genome, and it appears that many genes display different splice forms in cancerous tissue than in normal human tissues.
Lee, Christopher, Roy, Meenakshi, Xu, Qiang   +2 more
core   +2 more sources

Distinct Genetic Alterations in Colorectal Cancer [PDF]

, 2010
Colon cancer (CRC) development often includes chromosomal instability (CIN) leading to amplifications and deletions of large DNA segments. Epidemiological, clinical, and cytogenetic studies showed that there are considerable differences between CRC ...
Alejandro A. Schäffer, Duane T. Smoot, Edward Lee, Hassan Ashktorab, Hassan Brim, Mohammad Daremipouran, Ulrich Zanger   +6 more
core   +2 more sources

Multiple Tests of Association with Biological Annotation Metadata [PDF]

, 2006
We propose a general and formal statistical framework for the multiple tests of associations between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Dudoit, Sandrine, Keles, Sunduz, van der Laan, Mark J.   +2 more
core   +1 more source