Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand [PDF]
Clinical and Translational ScienceThiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases ...
Mohitosh Biswas +3 more
doaj +3 more sources
مجلة كلية الطب, 2018 Background: Thiopurines are essential medications in Acute Lymphoblastic Leukemia (ALL) treatment protocols as anti-cancer agents since long time; however, their use might result in unexpected toxicities in ALL children due to the low thiopurine S ...
Nawar S. Mohammed +3 more
doaj +3 more sources
Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy [PDF]
Frontiers in PharmacologyBackgroundThiopurine drugs are widely used as immunosuppressants and chemotherapeutic agents in clinical practice, but their adverse effects significantly limit their clinical application. TPMT c.719A>G (rs1142345) and NUDT15 c.415C>T (rs116855232)
Chenyu Zhao, Chenyu Zhao, Hui Huang
doaj +2 more sources
Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease [PDF]
The Saudi Journal of GastroenterologyBackground: Azathioprine, a common inflammatory bowel disease (IBD) treatment, carries a myelosuppression risk, particularly leukopenia. Thiopurine methyltransferase (TPMT) genotyping can predict azathioprine-induced leukopenia (AIL), but data on TPMT ...
Yaser K. Meeralam +7 more
doaj +2 more sources
Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED +2 more
doaj +1 more source
Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency
Metabolites, 2023 Tioguanine is metabolised by fewer enzymatic steps compared to azathioprine and mercaptopurine, without generating 6-methylmercaptopurine ribonucleotides.
Debbie S. Deben +6 more
doaj +1 more source
Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines. [PDF]
PLoS ONE, 2017 Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as ...
Amit P Bhavsar +5 more
doaj +1 more source
Journal of Pediatric Research, 2022 Aim:Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene.
Eda Ataseven +4 more
doaj +1 more source
Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population [PDF]
Libyan Journal of Medicine, 2015 Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene.
Hamza Ben Zeglam +7 more
doaj +1 more source
Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure. [PDF]
PLoS ONE, 2011 Thiopurine methyltransferase (Tpmt) is the primary enzyme responsible for deactivating thiopurine drugs. Thiopurine drugs (i.e., thioguanine [TG], mercaptopurine, azathioprine) are commonly used for the treatment of cancer, organ transplant, and ...
Amira Hosni-Ahmed +3 more
doaj +1 more source