Results 61 to 70 of about 8,275 (209)

Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning, Mendelian randomization (MR), and molecular docking—to elucidate the biological basis of AZA ...
Zhijun Xie, Hang Lei, Pengcheng Zhang, Zhi Li, Wenfu Tang   +4 more
wiley   +1 more source

Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen, Natasha J. Petry, Max Weaver, Ethan Weeder, Amanda Massmann   +4 more
wiley   +1 more source

Frequency of the most prevalent Thiopurine S-Methyl Trasferase alleles in referrals to Shariati Hospital in Tehran

Iranian South Medical Journal, 2009
Background: Patients with low or intermediate TPMT enzyme activity are at increased risk to develop severe hematopoietic toxicity after taking standard doses of thiopuring medications.
Mehdi Azadi, Saeed Kaviani, Masood Soleimani, Mehrdad Norouzi nia, Abbas Haji fathali   +4 more
doaj  

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

BMC Gastroenterology, 2021
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively.
Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma   +9 more
doaj   +1 more source

From Pharmacogenetics to Pharmacometabolomics: SAM Modulates TPMT Activity

Pharmacogenomics, 2014
In the present study, the influence of SAM on TPMT activity in vivo on human subjects was investigated.A total of 1017 donors from the Estonian Genome Center of the University of Tartu (Estonia) were genotyped for common TPMT variants, evaluated for TPMT activity, SAM levels, a set of 19 biochemical and ten hematological parameters and demographic data.
Karas-Kuželički, Nataša, Šmid, Alenka, Tamm, Riin, Metspalu, Andres, Mlinarič-Raščan, Irena   +4 more
openaire   +2 more sources

Clinical applications of pharmacogenomics [PDF]

, 2017
Indexación: Scopus.Pharmacogenomics is an emergent field aimed at tailoring pharmacological therapy. Genetic polymorphisms can modify the expression and function of enzymes and proteins involved in drug metabolism, affecting absorption, distribution ...
Cayún, J.P., Escalante, P., Gallegos, B., Lares-Asseff, I., Meneses, F., Miranda, C., Quiñones, L., Roco, Á., Varela, N., Zaruma-Torres, F.   +9 more
core   +1 more source

Uptake of DPYD and UGT1A1 testing in Italy and adherence to pharmacogenetic guidelines: A 5‐year perspective from an EQA provider

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 445-456, February 2026.
Aims Pharmacogenetic implementation requires awareness of the state‐of‐the‐art practice of laboratories providing pharmacogenetic testing. This study investigated how pharmacogenetic guidelines and recommendations have been implemented over time by Italian laboratories participating in the external quality assessment (EQA) Pharmaco‐scheme established ...
Rossana Roncato, Samantha Perfler, Diletta Pasin, Elena Peruzzi, Michael Woodcock, Henry Thomas, Rebecca Goodall, Simon J. Patton, Erika Cecchin   +8 more
wiley   +1 more source

Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Clinical and Translational Science, 2023
The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on
Kelsey J. Cook, Victoria Grusauskas, Lucy Gloe, Benjamin Q. Duong, Renee C. Gresh, E. Anders Kolb, Manisha Bansal, Allison S. Bechtel, Ramamoorthy Nagasubramanian, Susan M. Kirwin, Kathryn V. Blake, Nathan D. Seligson   +11 more
doaj   +1 more source

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

PLoS Currents, 2011
Azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine (TG) are thiopurine drugs. These agents are indicated for the treatment of various diseases including hematologic malignancies, inflammatory bowel disease (IBD), rheumatoid arthritis, and as immunosuppressants in solid organ transplants.
Nguyen, Christine M., Mendes, Margaret A.S., Ma, Joseph D.   +2 more
openaire   +3 more sources

From metabonomics to pharmacometabonomics: The role of metabolic profiling in personalized medicine [PDF]

, 2016
Variable patient responses to drugs are a key issue for medicine and for drug discovery and development. Personalised medicine, that is the selection of medicines for subgroups of patients so as to maximise drug efficacy and minimise toxicity, is a key ...
Abo, Abrahams, Andersson, Backshall, Bales, Clayton, Clayton, Coen, Condray, Coughtrie, Cunningham, Dai, Dona, Ellero-Simatos, Everett, Everett, Everett, Everett, Fiehn, Gamage, Gupta, Hao, Holmes, Holmes, Holmes, Huang, Iles, Ji, Joseph, Kaddurah-Daouk, Kaddurah-Daouk, Kaddurah-Daouk, Kaddurah-Daouk, Kapoor, Karas-Kuželički, Kettunen, Keun, Kwon, Lazarou, Lee, Lewis, Li, Lindon, Lindon, Lindon, Lindon, Lindon, Liu, Maruthur, McPhail, Miolo, Muhrez, Nam, Neavin, Nicholson, Nicholson, Park, Patel, Perlis, Phapale, Possamai, Puskarich, Rahmioglu, Rhee, Robinette, Rotroff, Rueedi, Salari, Serrano-Contreras, Shah, Shin, Shin, Sjöberg, Smith, Suhre, Suhre, Theodoridis, Trupp, Urban, Wang, Wang-Sattler, Wikoff, Wilson, Winnike, Yerges-Armstrong, Zhu   +85 more
core   +2 more sources