TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis [PDF]
JCI Insight, 2021 Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies.
Sherilyn Grill +10 more
doaj +4 more sources
TPP1 is associated with risk of advanced precursors and cervical cancer survival.
PLoS ONEIt is unclear how telomere-binding protein TPP1 interacts with human telomerase reverse transcriptase (hTERT) and influences cervical cancer development and progression. This study included all eligible 156 cervical cancers diagnosed during 2003-2008 and
Qiao-Li Wang +7 more
doaj +6 more sources
POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics [PDF]
Structure, 2012 SummaryHuman telomeres possess a single-stranded DNA (ssDNA) overhang of TTAGGG repeats, which can self-fold into a G-quadruplex structure. POT1 binds specifically to the telomeric overhang and partners with TPP1 to regulate telomere lengthening and ...
Myong, Sua +3 more
core +4 more sources
Functional Interaction Between Telomere Protein TPP1 and Telomerase [PDF]
Genes & Development, 2010 Human chromosome end-capping and telomerase regulation require POT1 (Protection of Telomeres 1) and TPP1 proteins, which bind to the 3′ ssDNA extension of human telomeres.
Cech, Thomas R. +3 more
core +4 more sources
Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. [PDF]
PLoS ONE, 2013 Radiotherapy is one of the major therapeutic strategies in cancer treatment. The telomere-binding protein TPP1 is an important component of the shelterin complex at mammalian telomeres.
Lei Yang +12 more
doaj +2 more sources
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo [PDF]
Molecular and Cellular Biology, 2010 Recruitment to telomeres is a pivotal step in the function and regulation of human telomerase; however, the molecular basis for recruitment is not known.
Terns, Michael P. +15 more
core +7 more sources
The POT1-TPP1 telomere complex is a telomerase processivity factor [PDF]
Nature, 2007 Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing deleterious degradation and fusion events.
Feng Wang +13 more
core +5 more sources
Structure of active human telomerase with telomere shelterin protein TPP1 [PDF]
Nature, 2022 Human telomerase is a RNA–protein complex that extends the 3′ end of linear chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG1.
He, Yao +5 more
core +5 more sources
The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7 [PDF]
Journal of Biological Chemistry, 2014 The telomeric shelterin component TPP1 has critical functions in telomeric protein complex assembly and telomerase recruitment and regulation. Here we identify USP7 as a novel interacting protein of the oligonucleotide/oligosaccharide-binding fold of ...
Zemp, I., Lingner, J.
core +4 more sources
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline [PDF]
Life Science Alliance, 2022 A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
Jacqueline V Graniel +19 more
doaj +4 more sources