The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action [PDF]
Cell Reports, 2018 Summary: Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function.
Jayakrishnan Nandakumar +1 more
exaly +6 more sources
POT1-TPP1 telomere length regulation and disease [PDF]
Computational and Structural Biotechnology Journal, 2020 Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primarily ...
Emmanuel Skordalakes
exaly +7 more sources
POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance
Computational and Structural Biotechnology Journal, 2022 Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1.
Emmanuel Skordalakes, Cory Rice
exaly +5 more sources
Shelterin Component TPP1 Drives Tumor Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma [PDF]
BiomedicinesBackground/Objectives: Telomere dysfunction and the shelterin complex are implicated in cancer, yet the specific functions and interactions of telomerase and shelterin genes in hepatocellular carcinoma (HCC) tumorigenesis remain poorly understood.
Jung Eun Jang +9 more
doaj +3 more sources
Systematic discovery of disease-modifying targets by prediction from knowledge graph-based AI model and experimental validation: Parkinson’s disease case [PDF]
Computational and Structural Biotechnology JournalThe development of disease-modifying therapies (DMTs) for Parkinson’s disease (PD) remains a critical unmet need. Despite extensive research efforts, no therapy capable of slowing or halting PD progression has been approved.
Minyoung So +7 more
doaj +2 more sources
Cell Reports, 2019 Summary: Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation. Telomerase action depends on the telomeric protein TPP1, which recruits telomerase to telomeres and facilitates processive DNA ...
Jayakrishnan Nandakumar +2 more
exaly +3 more sources
Antibiotic treatment reveals the contributions of the gut microbiome to CLN2 disease in the central and enteric nervous system [PDF]
Scientific ReportsThe Neuronal Ceroid Lipofuscinoses (NCLs) are fatal inherited lysosomal storage diseases, with pronounced neuron loss in the central nervous system (CNS). Gastrointestinal issues are frequently reported by people with NCLs, although mechanisms underlying
Ewa A. Ziółkowska +9 more
doaj +2 more sources
Recreating pathophysiology of CLN2 disease and demonstrating reversion by TPP1 gene therapy in hiPSC-derived retinal organoids and retina-on-chip [PDF]
Cell Reports MedicineSummary: Mutations in the tripeptidyl peptidase 1 (TPP1) gene lead to neuronal ceroid lipofuscinosis type 2 (CLN2), characterized by lysosomal accumulation of lipofuscins predominantly in the brain and retina.
Serena Corti +24 more
doaj +2 more sources
Heat stress and stocking density disrupt telomere maintenance through shelterin complex dysregulation and oxidative damage in broiler chickens [PDF]
BMC Veterinary ResearchBackground Heat stress and high stocking density are major stressors in broiler chickens, compromising welfare and productivity. These stressors can induce oxidative damage and disrupt DNA structure, and potentially accelerate cellular aging.
Shahab Bahadoran +2 more
doaj +2 more sources
TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres [PDF]
Cell ReportsSummary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1, and RAP1) that can assemble into various subcomplexes in ...
Tomáš Janovič +3 more
doaj +2 more sources