Results 141 to 150 of about 37,032,341 (244)

One‐Pot Biphasic Photocatalytic CO2‐to‐Carbonylation Cascades

Angewandte Chemie, EarlyView.
Bioinspired biphasic compartmentalization enables one‐pot cascades where photocatalytic CO2 reduction generates CO for carbonylative cross‐couplings to synthesize complex organic products, including a pharmaceutical. ABSTRACT Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO2 into complex chemicals that are ...
Sampurna Mitra, David M. Vahey, Shannon A. Bonke, Erwin Reisner   +3 more
wiley   +2 more sources

pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging

Advanced NanoBiomed Research, EarlyView.
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang, Liwei Liu, Jiayuan Zhu, Xinghao Hu, Changkui Fu, Yao Wang, Lining Arnold Ju, Thomas P. Davis, Andriansjah Rukmana, Shaohua Ma, Zheng Zhang, Ruirui Qiao   +11 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +2 more sources

Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT_1A Agonist, in Patients With Parkinson Disease Psychosis: A Pilot Study. [PDF]

Neurol Clin Pract, 2023
Isaacson SH, Goldstein M, Pahwa R, Singer C, Klos K, Pucci M, Zhang Y, Crandall D, Koblan KS, Navia B, Parkinson's Psychosis TAAR1 Study Group.   +10 more
europepmc   +1 more source

Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α₂-adrenoceptor and trace amine-associated receptor 1 ligand. [PDF]

Pharmacol Rep, 2023
Kotańska M, Marcinkowska M, Kuder KJ, Walczak M, Bednarski M, Siwek A, Kołaczkowski M.   +6 more
europepmc   +1 more source

Understanding the Molecular Basis of Trace Amine-Associated Receptor 1 Activation by Thyronamines and Related Analogs [PDF]

, 2007
Thyroid hormone is known to increase metabolism, core body temperature, and cardiac performance by regulating gene expression through the thyroid hormone nuclear receptors. These transcriptional effects have a slow onset and occur within hours to days.
Tan, Edwin Saavedra
core  

Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies. [PDF]

Wellcome Open Res, 2023
Siafis S, McCutcheon R, Chiocchia V, Ostinelli EG, Wright S, Stansfield C, Juma DO, Mantas I, Howes OD, Rutigliano G, Ramage F, Tinsdeall F, Friedrich C, Milligan L, Moreno C, Elliott JH, Thomas J, Macleod MR, Sena ES, Seedat S, Salanti G, Potts J, Cipriani A, Leucht S, GALENOS team.   +24 more
europepmc   +1 more source

Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities. [PDF]

ACS Pharmacol Transl Sci, 2022
Nair PC, Chalker JM, McKinnon RA, Langmead CJ, Gregory KJ, Bastiampillai T.   +5 more
europepmc   +1 more source

Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: a living systematic review and meta-analysis of human and non-human studies.

This project pertains to the third living systematic review (LSR3) of the GALENOS project. Its goal is to synthesize and triangulate evidence from both human and non-human studies to evaluate the efficacy, safety, and mechanisms of action of trace amine ...
Malcolm Robert Macleod, Virginia Chiocchia, Spyridon Siafis   +2 more
core   +1 more source