Results 161 to 170 of about 37,032,341 (244)

Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry

, 2013
Trace amines (TAs), such as b-phenylethylamine (b-PEA), tyramine, 3-iodothyronamine (T1AM), octopamine, tryptamine and synephrine, are found at low levels in multiple tissues in the periphery and brain of mammals but their physiological functions remain ...
P. Fossa, Gainetdinov, R. R., FRANCHINI, Silvia, BRASILI, Livio, Cichero, E., Espinoza, S.   +5 more
core  

JP-14: A Trace Amine-Associated Receptor 1 Agonist with Anti-Metabolic Disorder Potential. [PDF]

Int J Mol Sci
Marcinkowska M, Sniecikowska J, Głuch-Lutwin M, Mordyl B, Bednarski M, Bucki A, Sapa M, Kubacka M, Siwek A, Zagórska A, Sapa J, Kołaczkowski M, Kotańska M.   +12 more
europepmc   +1 more source

Synergistic Effect on Enhanced Oil Recovery in High Salinity Carbonate Reservoirs Using a Novel PEI‐Functionalized Carbon Nanotube Nanocomposite

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Enhancing oil recovery (EOR) in mature reservoirs is hindered by high interfacial tension (IFT) and oil‐wet rock formations, especially under harsh, high‐salinity conditions. This study aims to overcome these limitations by synthesizing a novel carbon nanotube nanocomposite covalently grafted with polyethylenimine and non‐covalently ...
Mohamed Abu Shuheil, Dilipkumar S. Patel, N. Beemkumar, Tariq Abdulkader Alrihaim, Dhirendra Nath Thatoi, Ripendeep Singh, Rohit Kumar, Parminder Singh, Ahmad Khalid   +8 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP. [PDF]

Neurochem Res
Harsing LG, Szénási G, Fehér B, Miklya I.   +3 more
europepmc   +1 more source

Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics

, 2012
Background: Trace amines, compounds structurally related to classical biogenic amines, represent endogenous ligands of the trace amine-associated receptor 1 (TAAR1). Because trace amines also influence the activity of other targets, selective ligands are
Sotnikova, TD (15665264), Bradaia, A (15665276), Biemans, B (15665282), Morairty, SR (15665267), Moreau, JL (15665261), Velazquez-Sanchez, C (15665201), Caron, MG (15665288), Canales, JJ (15665159), Pouzet, B (15665285), Kilduff, TS (15665279), Hoener, MC (15665177), Norcross, RD (15665273), Gainetdinov, RR (15665189), Ferragud, A (15665198), Revel, FG (15665258), Wallace, TL (15665291), Wettstein, JG (15665294), Harmeier, A (15665186), Groebke Zbinden, K (15665270)   +18 more
core  

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source