Results 91 to 100 of about 1,066 (152)

Gut microbe-derived aromatic trace amines mediate individual variability in response to herbal medicine CDD-2101 for functional constipation

Pharmacological Research
Functional constipation (FC), a common gastrointestinal disorder, poses significant therapeutic challenges due to the limited efficacy and durability of current therapies. A novel strategy for addressing FC involves the targeting of gut dysbiosis.
Shifa Ruan, Yaqi Li, Ziwan Ning, Yunlyu Li, Qin Liu, Wenyu Fang, Xuanting Jiang, Jingyuan Luo, Hetong Gao, Wing Lam Wendy To, Lin Zhu, Chengyuan Lin, Chunsu Yuan, Haitao Xiao, Lixiang Zhai, Zhaoxiang Bian   +15 more
doaj   +1 more source

Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations

Human Genomics
Trace Amine Associated Receptor 1 (TAAR1) is a novel pharmaceutical target under investigation for the treatment of several neuropsychiatric conditions.
Britto Shajan, Shashikanth Marri, Tarun Bastiampillai, Karen J. Gregory, Shane D. Hellyer, Pramod C. Nair   +5 more
doaj   +1 more source

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

Frontiers in Pharmacology
Background4-substituted 2,6-dimethoxyphenethylamines and the corresponding amphetamines (so-called pseudo [Ψ] derivatives) are a hitherto mostly unexplored group of psychedelics.
Karolina E. Kolaczynska, Karolina E. Kolaczynska, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti, Matthias E. Liechti, Dino Luethi, Dino Luethi   +7 more
doaj   +1 more source

Synthesis, radiolabeling and biological evaluation of a novel trace amine-associated receptor 1 (TAAR1) PET radioligand

Nuclear Medicine and Biology, 2021
Ahmed Haider, Jiyun Sun, Jiahui Chen, Jian Rong, Tuo Shao, Lu Wang, Hao Xu, Ming-Rong Zhang, Steven Liang   +8 more
openaire   +1 more source

Synthesis, Radiolabeling and Biological Evaluation of a Novel Trace Amine-Associated Receptor 1 (TAAR1) PET radioligand

Synthesis, Radiolabeling and Biological Evaluation of a Novel Trace Amine-Associated Receptor 1 (TAAR1) PET radioligand
Objectives: Trace amine-associated receptor 1 (TAAR1) activation ultimately results in the attenuation of monoaminergic signaling. Accordingly, TAAR1 has emerged as a valuable target for the modulation of dopaminergic and adrenergic signal transduction.
openaire   +1 more source

An Exploratory Study of High-Concentration Trace Amine Effects and Adrenoceptor Expression Patterns in SH-SY5Y Cells and Neuroblastoma. [PDF]

Int J Mol Sci
Lopachev AV, Kazanskaya RB, Gainetdinov RR, Kanov EV, Vaganova AN.   +4 more
europepmc   +1 more source

A potential role for trace amines in the treatment of septic shock. [PDF]

J Intensive Med
Broadley KJ, Voisey AC, Ford WR, Broadley HD.   +3 more
europepmc   +1 more source

The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition. [PDF]

Biochem Biophys Rep
Luo L, Zhang T, Liang L, Chen W, Wang T, Chen W, Xiao H, Zhang G.   +7 more
europepmc   +1 more source

Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments. [PDF]

Cardiovasc Toxicol
Pinckaers NET, Blankesteijn WM, Leenders P, Weltjens E, Opperhuizen A, van Schooten FJ, Vrolijk M.   +6 more
europepmc   +1 more source

Dually Acting Ligands Targeting Serotonin Receptors: Implications in CNS Disorders. [PDF]

J Med Chem
Trybała W, Grychowska K, Malikowska-Racia N, Nikiforuk A, Popik P, Zajdel P.   +5 more
europepmc   +1 more source