Results 71 to 80 of about 1,066 (152)
Frontiers in Pharmacology, 2018 Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Maria Qatato +5 more
doaj +1 more source
PLoS ONE, 2019 BackgroundMethamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement ...
Jennifer M Loftis +6 more
doaj +1 more source
Recent Advances in Mammalian Olfactory Receptor Function and Structure
Sensory Neuroscience, Volume 1, Issue 1, April 2025.Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin +9 more
wiley +1 more source
Drug Development Research, Volume 85, Issue 4, June 2024.Abstract Schizophrenia (SZ) is a serious, destructive neurodevelopmental disorder. Antipsychotic medications are the primary therapy approach for this illness, but it's important to pay attention to the adverse effects as well. Clinical studies for SZ are currently in phase ΙΙΙ for SEP‐363856 (SEP‐856)‐a new antipsychotic that doesn't work on dopamine ...
Mengdie Li +7 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Alzheimer disease (AD) is the main cause of dementia with approximately 27 million people affected worldwide. Beta-Amyloid peptide (Ab) is elevated in the brains of patients with AD and is believed to be causative in the disease process. Ab can reduce long-term potentiation (LTP), a form of synaptic plasticity that is closely associated with learning ...
Leo, Damiana +4 more
openaire +2 more sources
Diabetes, Obesity and Metabolism, Volume 26, Issue 6, Page 2466-2475, June 2024.Abstract Background Metabolic syndrome (MetS), which can be induced or exacerbated by the current class of antipsychotic drugs, is highly prevalent in patients with schizophrenia and presents significant challenges to lifetime disease management. Supported by initial clinical results, trace amine‐associated receptor 1 (TAAR1) agonists have emerged as ...
Snežana Milanović +6 more
wiley +1 more source
Triangulating evidence from the GALENOS living systematic review on trace amine-associated receptor 1 (TAAR1) agonists in psychosis [PDF]
The British Journal of PsychiatryBackgroundTrace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.AimsTo evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and
Katharine A. Smith +19 more
openaire +3 more sources
Frontiers in Neuroscience, 2015 The newly discovered trace amine-associated receptor 1 (TAAR1) has the ability to regulate both dopamine function and psychostimulant action. Here, we tested in rats the ability of RO5203648, a selective TAAR1 partial agonist, to modulate the ...
Rachel eCotter +7 more
doaj +1 more source
Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol
Substance Abuse: Research and Treatment, 2013 Background Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and ...
Laurie J. Lynch +5 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Major gene effects on traits associated with substance use disorders are rare. Previous findings in methamphetamine drinking (MADR) lines of mice, bred for high or low voluntary MA intake, and in null mutants demonstrate a major impact of the trace amine-
Cheryl Reed +8 more
doaj +1 more source