Results 81 to 90 of about 1,066 (152)

Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies. [PDF]

Wellcome Open Res, 2023
Siafis S, McCutcheon R, Chiocchia V, Ostinelli EG, Wright S, Stansfield C, Juma DO, Mantas I, Howes OD, Rutigliano G, Ramage F, Tinsdeall F, Friedrich C, Milligan L, Moreno C, Elliott JH, Thomas J, Macleod MR, Sena ES, Seedat S, Salanti G, Potts J, Cipriani A, Leucht S, GALENOS team.   +24 more
europepmc   +1 more source

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1

Frontiers in Pharmacology, 2017
Activation of trace amine-associated receptor 1 (TAAR1) in endocrine pancreas is involved in weight regulation and glucose homeostasis. The purpose of this study was the identification and characterization of potential TAAR1 variants in patients with ...
Jessica Mühlhaus, Juliane Dinter, Sabine Jyrch, Alexander Teumer, Simon F. Jacobi, Georg Homuth, Peter Kühnen, Susanna Wiegand, Annette Grüters, Henry Völzke, Henry Völzke, Klemens Raile, Klemens Raile, Gunnar Kleinau, Gunnar Kleinau, Heiko Krude, Heike Biebermann   +16 more
doaj   +1 more source

BRET biosensors to study GPCR biology, pharmacology and signal transduction

Frontiers in Endocrinology, 2012
Bioluminescence Resonance Energy Transfer (BRET) based biosensors have been extensively used over the last decade to study protein-protein interactions and intracellular signal transduction in living cells.
Ali eSalahpour, Stefano eEspinoza, Bernard eMasri, Vincent eLam, Lawrence eBarak, Raul R Gainetdinov   +5 more
doaj   +1 more source

Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. [PDF]

Mol Psychiatry, 2022
Grinchii D, Hoener MC, Khoury T, Dekhtiarenko R, Nejati Bervanlou R, Jezova D, Dremencov E.   +6 more
europepmc   +1 more source

Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-N-(3,5-dimethylphenyl)piperidine-1-carboxamide Hydrochloride (AP163) for the Treatment of Psychotic Disorders. [PDF]

Int J Mol Sci, 2022
Krasavin M, Peshkov AA, Lukin A, Komarova K, Vinogradova L, Smirnova D, Kanov EV, Kuvarzin SR, Murtazina RZ, Efimova EV, Gureev M, Onokhin K, Zakharov K, Gainetdinov RR.   +13 more
europepmc   +1 more source

The association between trace amine-associated receptor 1 (TAAR1) genetic mutations and neuropsychiatric disorders

Genomic Psychiatry
Trace amine-associated receptor 1 (TAAR1) is an emerging drug target for the treatment of neuropsychiatric conditions. Several TAAR1-targeted therapeutics are currently in clinical and preclinical development. Emerging studies highlight links between TAAR1 single-nucleotide variants/polymorphisms and neuropsychiatric disorders.
Britto Shajan, Tarun Bastiampillai, Pramod C. Nair   +2 more
openaire   +1 more source

D-Cell Hypothesis (Trace Amine Hypothesis) of Schizophrenia, and importance of Trace Amine-Associated Receptor, Type 1 (TAAR1)

Pharmacovigilance and Pharmacoepidemiology, 2015
Mesolimbic dopamine (DA) hyperactivity is a well-known pathophysiological hypothesis of schizophrenia. The author shows a hypothesis to clarify the molecular basis of mesolimbic DA hyperactivity of schizophrenia. An immunohistochemical method was used to show D-neuron (trace amine (TA) neuron) decrease in the nucleus accumbens (Acc) of postmortem ...
openaire   +1 more source

A Pilot Study on a Possible Mechanism behind Olfactory Dysfunction in Parkinson’s Disease: The Association of TAAR1 Downregulation with Neuronal Loss and Inflammation along Olfactory Pathway

Brain Sciences
Parkinson’s disease (PD) is characterized not only by motor symptoms but also by non-motor dysfunctions, such as olfactory impairment; the cause is not fully understood.
Mei-Xuan Zhang, Hui Hong, Yun Shi, Wen-Yan Huang, Yi-Meng Xia, Lu-Lu Tan, Wei-Jiang Zhao, Chen-Meng Qiao, Jian Wu, Li-Ping Zhao, Shu-Bing Huang, Xue-Bing Jia, Yan-Qin Shen, Chun Cui   +13 more
doaj   +1 more source

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [F]DOPA PET in Naïve and Cocaine-Treated Mice

Molecular Imaging
Purpose Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders.
David R. Bonsall PhD, Michelle Kokkinou PhD, Els F. Halff PhD, Grazia Rutigliano PhD, Sac-Pham Tang MSc, Mattia Veronese PhD, Elaine E. Irvine PhD, Dominic J. Withers FRCP, PhD, Lisa A. Wells PhD, Sridhar Natesan PhD, Irene Gerlach PhD, Štefan Holiga PhD, Marius C. Hoener PhD, Oliver D. Howes MRCpsych, PhD   +13 more
doaj   +1 more source

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats

Frontiers in Psychiatry
IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain.
Ilya S. Zhukov, Ilya S. Zhukov, Yazen Alnefeesi, Natalya A. Krotova, Vsevolod V. Nemets, Konstantin A. Demin, Marina N. Karpenko, Evgeny A. Budygin, Evgeny V. Kanov, Evgeny V. Kanov, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Petr D. Shabanov, Michael Bader, Natalia Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +18 more
doaj   +1 more source