Results 41 to 50 of about 61,594 (230)
Trained immunity modulates inflammation-induced fibrosis
Nature Communications, 2019 Innate immune cells can be trained by some stimuli or pathogen exposures to be metabolically and epigenetically altered such that they have different responses to subsequent exposures.
Mohamed Jeljeli +9 more
doaj +1 more source
Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
Frontiers in Immunology, 2022 Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a ...
P. Spencer Gill +8 more
doaj +1 more source
Therapeutic targeting of trained immunity [PDF]
Nature Reviews Drug Discovery, 2019 Immunotherapy is revolutionizing the treatment of diseases in which dysregulated immune responses have an important role. However, most of the immunotherapy strategies currently being developed engage the adaptive immune system. In the past decade, both myeloid (monocytes, macrophages and dendritic cells) and lymphoid (natural killer cells and innate ...
Willem J. M. Mulder +4 more
openaire +4 more sources
Advances in immune response to pulmonary infection: Nonspecificity, specificity and memory
Chronic Diseases and Translational Medicine, 2023 The lung immune response consists of various cells involved in both innate and adaptive immune processes. Innate immunity participates in immune resistance in a nonspecific manner, whereas adaptive immunity effectively eliminates pathogens through ...
Jianqiao Xu, Lixin Xie
doaj +1 more source
Induction of Trained Immunity by Recombinant Vaccines
Frontiers in Immunology, 2021 Vaccines represent an important strategy to protect humans against a wide variety of pathogens and have even led to eradicating some diseases. Although every vaccine is developed to induce specific protection for a particular pathogen, some vaccine ...
Camila Covián +5 more
doaj +1 more source
Immunization Training: Right or Privilege? [PDF]
American Journal of Pharmaceutical Education, 2012 Immunization training in US colleges and schools of pharmacy has progressed quickly and significantly. The first formal national training and certificate program aimed at pharmacists was introduced by the American Pharmacists Association in 1996 and was quickly adopted as a curricular model and component by many colleges and schools.1-3 The 1990s also ...
Frank, Romanelli, Trish, Freeman
openaire +2 more sources
Resolving trained immunity with systems biology [PDF]
European Journal of Immunology, 2021 AbstractTrained immunity is characterized by long‐term functional reprogramming of innate immune cells following challenge with pathogens or microbial ligands during infection or vaccination. This cellular reprogramming leads to increased responsiveness upon restimulation, and is mediated through epigenetic and metabolic modifications.
Koeken, V.A.C.M. +4 more
openaire +4 more sources
Lnc-ing Trained Immunity to Chromatin Architecture
Frontiers in Cell and Developmental Biology, 2019 Human innate immune cells exposed to certain infections or stimuli develop enhanced immune responses upon re-infection with a different second stimulus, a process termed trained immunity.
Stephanie Fanucchi +2 more
doaj +1 more source
The Role of Cell Metabolism in Innate Immune Memory
Journal of Innate Immunity, 2020 Immunological memory is classically attributed to adaptive immune responses, but recent studies have shown that challenged innate immune cells can display long-term functional changes that increase nonspecific responsiveness to subsequent infections ...
Anaisa Valido Ferreira +2 more
doaj +1 more source
Trained Immunity Confers Prolonged Protection From Listeriosis
Frontiers in Immunology, 2021 Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection
Charlotte Théroude +9 more
doaj +1 more source