Results 91 to 100 of about 4,501,017 (312)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Transcriptional control of stem cell fate by E2Fs and Pocket Proteins

Frontiers in Genetics, 2015
E2F transcription factors and their regulatory partners, the pocket proteins (PPs), have emerged as essential regulators of stem cell fate control in a number of lineages.
Lisa Marie Julian, Alexandre eBlais, Alexandre eBlais   +2 more
doaj   +1 more source

Genetic Variation in Transcription Factor Binding Sites

International Journal of Molecular Sciences, 2023
The interaction between transcription factors (TFs) and DNA is the core process that determines the state of a cell’s transcriptome [...]
openaire   +2 more sources

Bacterial RNA polymerase-DNA interaction - the driving force of gene expression and the target for drug action

Frontiers in Molecular Biosciences, 2016
DNA-dependent multisubunit RNA polymerase (RNAP) is the key enzyme of gene expression and a target of regulation in all kingdoms of life. It is a complex multifunctional molecular machine which, unlike other DNA-binding proteins, engages in extensive and
Sergei Borukhov, Jookyung Lee
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

The Genetic Code Kit: An Open-Source Cell-Free Platform for Biochemical and Biotechnology Education

Frontiers in Bioengineering and Biotechnology, 2020
Teaching the processes of transcription and translation is challenging due to the intangibility of these concepts and a lack of instructional, laboratory-based, active learning modules.
Layne C. Williams, Layne C. Williams, Nicole E. Gregorio, Nicole E. Gregorio, Byungcheol So, Byungcheol So, Wesley Y. Kao, Wesley Y. Kao, Alan L. Kiste, Pratish A. Patel, Katharine R. Watts, Katharine R. Watts, Javin P. Oza, Javin P. Oza   +13 more
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

Nature Communications, 2017
Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions
Samuel W. Lukowski, Luke R. Lloyd-Jones, Alexander Holloway, Holger Kirsten, Gibran Hemani, Jian Yang, Kerrin Small, Jing Zhao, Andres Metspalu, Emmanouil T. Dermitzakis, Greg Gibson, Timothy D. Spector, Joachim Thiery, Markus Scholz, Grant W. Montgomery, Tonu Esko, Peter M. Visscher, Joseph E. Powell   +17 more
doaj   +1 more source

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability.

Frontiers in Genetics, 2015
DNA replication and transcription are vital cellular processes during which the genetic information is copied into complementary DNA and RNA molecules.
Alessandra eBrambati, Arianna eColosio, Luca eZardoni, Lorenzo eGalanti, Giordano eLiberi, Giordano eLiberi   +5 more
doaj   +1 more source

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Science, 2016
Variation and transcription factor binding Little is known about the phenotypic and functional effects of genetic variants that result in amino acid changes within functional proteins. Barrera et al.
Luis A. Barrera, Anastasia Vedenko, Jesse V. Kurland, J. Rogers, Stephen S. Gisselbrecht, E. Rossin, Jaie C. Woodard, Luca Mariani, K. Kock, S. Inukai, T. Siggers, Leila Shokri, Raluca Gordân, Nidhi Sahni, C. Cotsapas, Tong Hao, S. Yi, Manolis Kellis, M. Daly, M. Vidal, D. Hill, M. Bulyk   +21 more
semanticscholar   +1 more source