Results 11 to 20 of about 4,501,017 (312)
Genetic Architecture of Transcription and Chromatin Regulation [PDF]
Genomics & Informatics, 2015 DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures.
Kwoneel Kim +3 more
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Transcription Factor-Based Genetic Engineering in Microalgae [PDF]
Plants, 2021 Sequence-specific DNA-binding transcription factors (TFs) are key components of gene regulatory networks. Advances in high-throughput sequencing have facilitated the rapid acquisition of whole genome assembly and TF repertoires in microalgal species.
Keiichi Mochdia, Shun Tamaki
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Genetic and Epigenetic Regulation of CCR5 Transcription [PDF]
Biology, 2012 The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia.
Rutger J. Wierda, Peter J. van den Elsen
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Transcriptional programming using engineered systems of transcription factors and genetic architectures [PDF]
Nature Communications, 2019 The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to ...
Ronald E Rondon +3 more
semanticscholar +4 more sources
Identifying the genetic determinants of transcription factor activity
Molecular Systems Biology, 2010 Analysis of parallel genotyping and expression profiling data has shown that mRNA expression levels are highly heritable. Currently, only a tiny fraction of this genetic variance can be mechanistically accounted for.
Eunjee Lee, Harmen J Bussemaker
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Genetic determinants of neuroglobin transcription [PDF]
neurogenetics, 2013 Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
Dimitri Avramopoulos +4 more
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Genetic and epigenomic mechanisms of mammalian circadian transcription [PDF]
Nature Structural & Molecular Biology, 2016 The mammalian molecular clock comprises a complex network of transcriptional programs that integrates environmental signals with physiological pathways in a tissue-specific manner. Emerging technologies are extending knowledge of basic clock features by uncovering their underlying molecular mechanisms, thus setting the stage for a 'systems' view of the
R. Papazyan, Yuxiang Zhang, M. Lazar
semanticscholar +4 more sources
Transcription of an Expanded Genetic Alphabet [PDF]
Journal of the American Chemical Society, 2009 Expansion of the genetic alphabet with a third base pair would have immediate biotechnology applications and also lay the foundation for a semisynthetic organism with an expanded genetic code. A variety of unnatural base pairs have been shown to be formed efficiently and selectively during DNA replication, and the pairs formed between the unnatural ...
Young Jun Seo +2 more
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CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application
Life, 2021 CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality.
Pei Du +5 more
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PLoS Computational Biology, 2023 Genetic feedback loops can be used by cells to regulate internal processes or to keep track of time. It is often thought that, for a genetic circuit to display self-sustained oscillations, a degree of cooperativity is needed in the binding and unbinding ...
Jasper Landman +2 more
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