Results 11 to 20 of about 5,231,452 (328)
Optimization of Transcription Factor Genetic Circuits
Biology, 2022 Transcription factors (TFs) affect the production of mRNAs. In essence, the TFs form a large computational network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends
Steven A. Frank
doaj +5 more sources
Transcription Factor-Based Genetic Engineering in Microalgae [PDF]
Plants, 2021 Sequence-specific DNA-binding transcription factors (TFs) are key components of gene regulatory networks. Advances in high-throughput sequencing have facilitated the rapid acquisition of whole genome assembly and TF repertoires in microalgal species.
Keiichi Mochdia, Shun Tamaki
doaj +3 more sources
Genetic and Epigenetic Regulation of CCR5 Transcription [PDF]
Biology, 2012 The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia.
Rutger J. Wierda, Peter J. van den Elsen
doaj +4 more sources
Genetic Architecture of Transcription and Chromatin Regulation [PDF]
Genomics & Informatics, 2015 DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures.
Kwoneel Kim +3 more
doaj +3 more sources
Transcriptional programming using engineered systems of transcription factors and genetic architectures [PDF]
Nature Communications, 2019 The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to ...
Ronald E Rondon +3 more
semanticscholar +4 more sources
Genetic determinants of neuroglobin transcription [PDF]
neurogenetics, 2013 Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
R, Wang +4 more
openaire +2 more sources
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Salmonella belongs to the Enterobacteriaceae family, a gram-negative, non-spore-forming, rod-shaped, motile, and pathogenic bacteria that transmit through unhygienic conditions.
Malaisamy Arunkumar +7 more
doaj +1 more source
NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Xiaoli Ru, T. Wen
semanticscholar +1 more source
CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application
Life, 2021 CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality.
Pei Du +5 more
doaj +1 more source
Transcription of an Expanded Genetic Alphabet [PDF]
Journal of the American Chemical Society, 2009 Expansion of the genetic alphabet with a third base pair would have immediate biotechnology applications and also lay the foundation for a semisynthetic organism with an expanded genetic code. A variety of unnatural base pairs have been shown to be formed efficiently and selectively during DNA replication, and the pairs formed between the unnatural ...
Young Jun, Seo +2 more
openaire +2 more sources