Results 21 to 30 of about 5,008,846 (367)

Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits.

PLoS Computational Biology, 2023
Genetic feedback loops can be used by cells to regulate internal processes or to keep track of time. It is often thought that, for a genetic circuit to display self-sustained oscillations, a degree of cooperativity is needed in the binding and unbinding ...
Jasper Landman, Sjoerd M Verduyn Lunel, Willem K Kegel   +2 more
doaj   +1 more source

Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching.

Genes & Development, 1992
Biochemical and genetic analysis of the embryonic to adult beta-like globin gene switch in chickens has led to the hypothesis that competition between the promoters of the cis-linked epsilon- and beta-globin genes for interaction with a shared enhancer ...
Kevin P. Foley, J. D. Engel
semanticscholar   +1 more source

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette [PDF]

Angewandte Chemie, 2020
AbstractSynthetic nucleic acids, with four non‐canonical nucleobases, can function as genetic materials. A comprehensive analysis of PCR amplification, transcription, reverse transcription, and cloning was done to screen for alternative genetic monomers.
Hui Yang, Elena Eremeeva, Mikhail Abramov, Piet Herdewijn   +3 more
openaire   +5 more sources

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions [PDF]

, 2005
Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities of homologous genes as well as non-homologous genes acting in ...
Baugh, L. Ryan, Brown, Eugene L., Hill, Andrew A., Hunter, Craig P., Slonim, Donna K., Wen, Joanne C.   +5 more
core   +2 more sources

Genetic Regulation of Transcription in the Endometrium in Health and Disease [PDF]

Frontiers in Reproductive Health, 2022
The endometrium is a complex and dynamic tissue essential for fertility and implicated in many reproductive disorders. The tissue consists of glandular epithelium and vascularised stroma and is unique because it is constantly shed and regrown with each menstrual cycle, generating up to 10 mm of new mucosa. Consequently, there are marked changes in cell
Sally Mortlock, Brett McKinnon, Grant W. Montgomery   +2 more
openaire   +3 more sources

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms

Вавиловский журнал генетики и селекции, 2021
Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases.
E. V. Ignatieva, E. A. Matrosova
doaj   +1 more source

Gene gating at nuclear pores prevents the formation of R loops [PDF]

, 2017
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops.
Aguilera López, Andrés, Gaillard, Hélène, García Benítez, Francisco   +2 more
core   +1 more source

Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone [PDF]

, 2012
We performed a genetic association study of rare variants and single nucleotide polymorphisms (SNPs) of UCMA/GRP and OPTN genes, in French-Canadian patients with Paget's disease of bone (PDB) and in healthy controls from the same population.
Albagha, Albagha, Avilion, Basu-Roy, Cancela, Chen, Chung, Desmet, Edith Gagnon, Ethel S. Siris, Fahmi, Gabriel Miltenberger-Miltenyi, Goode, Hocking, Jacques P. Brown, Jean Morissette, Laurin, Laurin, Layfield, Laëtitia Michou, Le Jeune, Lefebvre, Lucas, Luu-The, M. Leonor Cancela, Maruyama, Michou, Morissette, Natércia Conceição, Pankiv, Rath, Rezaie, Rousiere, Shankar, Singh, Staden, Surmann-Schmitt, Tagariello, Tong, van Staa, Viegas, Viegas   +41 more
core   +1 more source

Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

Molecular biology and evolution, 2017
Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF ...
Yi Peng, Chao-ying Cui, Yaoxi He, Yaoxi He, Ouzhuluobu, Hui Zhang, Deying Yang, Qu Zhang, Bianbazhuoma, Lixin Yang, Yibo He, Yibo He, Kun Xiang, Xiaoming Zhang, S. Bhandari, P. Shi, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Yongyue Pan, Cirenyangji, Baimayangji, Gonggalanzi, Cai-juan Bai, Bianba, Basang, Ciwangsangbu, Shuhua Xu, Shuhua Xu, Hua Chen, Shiming Liu, Tianyi Wu, X. Qi, B. Su   +34 more
semanticscholar   +1 more source

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]

, 2009
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Sofia Aligianni, Daniel H. Lackner, Steffi Klier, Gabriella Rustici, Brian T. Wilhelm, Samuel Marguerat, Sandra Codlin, Alvis Brazma, Robertus A. M. de Bruin, Jürg Bähler, Michael Snyder, J Bähler, LL Breeden, C Wittenberg, JR Nevins, CJ Sherr, JM Trimarchi, NF Lowndes, M Caligiuri, S Whitehall, Y Zhu, Z Maqbool, A Oliva, X Peng, G Rustici, B Baum, N Nakashima, S Tahara, S White, J Ayté, RA de Bruin, RA de Bruin, A Watson, Z Chu, C Dutta, E Kaufmann, T Pramila, CE Horak, VR Iyer, C Gordon, TJ Kelly, AB Martín-Cuadrado, DH Lackner, J Davey, N Yabana, S Marguerat, J Mata, J Mata, M Miyamoto, F Nadeem, C Heichinger, CJ McInerny, VL MacKay, B Mai, I Simon, A Bueno, PJ Kennedy, R Foster, CJ McInerny, Y Takayama, C Blackwell, Y Field, G Bosco, J Bähler, D Robyr, KM Flick, BE Bernstein, W Huber, VG Tusher, MN Boddy, R Lyne, WK Lim   +71 more
core   +7 more sources