Results 21 to 30 of about 966,346 (199)
Dinâmica ativa em sala de aula no ensino-aprendizado da transcrição gênica em ciências da saúde
Metodologias e Aprendizado, 2020 A metodologia ativa cria um ambiente propício para que o acadêmico tenha a possibilidade de ser resolutivo frente a um desafio, gerando o perfil profissional que está em consonância com as competências gerais dos profissionais da saúde.
Adroaldo Lunardelli +1 more
doaj +1 more source
Embodied Computational Evolution: Feedback Between Development and Evolution in Simulated Biorobots
Frontiers in Robotics and AI, 2021 Given that selection removes genetic variance from evolving populations, thereby reducing exploration opportunities, it is important to find mechanisms that create genetic variation without the disruption of adapted genes and genomes caused by random ...
Joshua Hawthorne-Madell +7 more
doaj +1 more source
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. [PDF]
PLoS Biology, 2008 Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters within coding regions activate transcription in particular mutants.
Vanessa Cheung +6 more
doaj +1 more source
Genetic and Epigenetic Regulation of CCR5 Transcription
Biology, 2012 The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia.
Rutger J. Wierda, Peter J. van den Elsen
doaj +1 more source
Wheat Breeding, Transcription Factories, and Genetic Interactions: New Perspectives
Frontiers in Plant Science, 2022 Epistatic interactions and negative heterosis have been shown to be associated with interchromosomal interactions in wheat. Physical gene-gene interactions between co-regulated genes clustered in “transcription factories” have been documented, and a ...
Richard B. Flavell
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Epistatic relationships reveal the functional organization of yeast transcription factors
Molecular Systems Biology, 2010 The regulation of gene expression is, in large part, mediated by interplay between the general transcription factors (GTFs) that function to bring about the expression of many genes and site‐specific DNA‐binding transcription factors (STFs).
Jiashun Zheng +8 more
doaj +1 more source
Genetic dissection of the RNA polymerase II transcription cycle
eLife, 2022 How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou +4 more
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source