Results 21 to 30 of about 5,189,368 (329)

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics [PDF]

, 2009
We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable.
A. Goldbeter, Benjamin Parent, C. P. Fall, Constant Vandermoëre, François Lemaire, I. S. Gradshteyn, Marc Lefranc, Pierre-Emmanuel Morant, Quentin Thommen   +8 more
core   +7 more sources

CRISPR-Based Genetic Switches and Other Complex Circuits: Research and Application

Life, 2021
CRISPR-based enzymes have offered a unique capability to the design of genetic switches, with advantages in designability, modularity and orthogonality.
Pei Du, Chunbo Lou, Xuejin Zhao, Qihui Wang, Xiangyu Ji, Weijia Wei   +5 more
doaj   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul, Balschun, Tobias, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Duerr, Richard H., Franke, Andre, Glas, Jürgen, Kamboh, M. Ilyas, Müller-Myhsok, Bertram, Olszak, Torsten, Pasciuto, Giulia, Seiderer, Julia, Wetzke, Martin, Wolf, Christiane   +14 more
core   +12 more sources

Transcription factor competition facilitates self-sustained oscillations in single gene genetic circuits.

PLoS Computational Biology, 2023
Genetic feedback loops can be used by cells to regulate internal processes or to keep track of time. It is often thought that, for a genetic circuit to display self-sustained oscillations, a degree of cooperativity is needed in the binding and unbinding ...
Jasper Landman, Sjoerd M Verduyn Lunel, Willem K Kegel   +2 more
doaj   +1 more source

Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone [PDF]

, 2012
We performed a genetic association study of rare variants and single nucleotide polymorphisms (SNPs) of UCMA/GRP and OPTN genes, in French-Canadian patients with Paget's disease of bone (PDB) and in healthy controls from the same population.
Albagha, Albagha, Avilion, Basu-Roy, Cancela, Chen, Chung, Desmet, Edith Gagnon, Ethel S. Siris, Fahmi, Gabriel Miltenberger-Miltenyi, Goode, Hocking, Jacques P. Brown, Jean Morissette, Laurin, Laurin, Layfield, Laëtitia Michou, Le Jeune, Lefebvre, Lucas, Luu-The, M. Leonor Cancela, Maruyama, Michou, Morissette, Natércia Conceição, Pankiv, Rath, Rezaie, Rousiere, Shankar, Singh, Staden, Surmann-Schmitt, Tagariello, Tong, van Staa, Viegas, Viegas   +41 more
core   +1 more source

Optogenetics for transcriptional programming and genetic engineering

Trends in Genetics, 2022
Optogenetics combines genetics and biophotonics to enable noninvasive control of biological processes with high spatiotemporal precision. When engineered into protein machineries that govern the cellular information flow as depicted in the central dogma, multiple genetically encoded non-opsin photosensory modules have been harnessed to modulate gene ...
Tien-Hung Lan, Lian He, Yun Huang, Yubin Zhou   +3 more
openaire   +2 more sources

Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching.

Genes & Development, 1992
Biochemical and genetic analysis of the embryonic to adult beta-like globin gene switch in chickens has led to the hypothesis that competition between the promoters of the cis-linked epsilon- and beta-globin genes for interaction with a shared enhancer ...
Kevin P. Foley, J. D. Engel
semanticscholar   +1 more source

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms

Вавиловский журнал генетики и селекции, 2021
Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases.
E. V. Ignatieva, E. A. Matrosova
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

Transcriptional programming using engineered systems of transcription factors and genetic architectures

Nature Communications, 2019
The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to ...
Ronald E Rondon, Thomas M. Groseclose, A. Short, Corey J. Wilson   +3 more
semanticscholar   +1 more source