Results 21 to 30 of about 4,501,017 (312)

Individual stage selector element mutations lead to reciprocal changes in beta- vs. epsilon-globin gene transcription: genetic confirmation of promoter competition during globin gene switching.

Genes & Development, 1992
Biochemical and genetic analysis of the embryonic to adult beta-like globin gene switch in chickens has led to the hypothesis that competition between the promoters of the cis-linked epsilon- and beta-globin genes for interaction with a shared enhancer ...
Kevin P. Foley, J. D. Engel
semanticscholar   +1 more source

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette [PDF]

Angewandte Chemie, 2020
AbstractSynthetic nucleic acids, with four non‐canonical nucleobases, can function as genetic materials. A comprehensive analysis of PCR amplification, transcription, reverse transcription, and cloning was done to screen for alternative genetic monomers.
Hui Yang, Elena Eremeeva, Mikhail Abramov, Piet Herdewijn   +3 more
openaire   +4 more sources

Genetic Regulation of Transcription in the Endometrium in Health and Disease [PDF]

Frontiers in Reproductive Health, 2022
The endometrium is a complex and dynamic tissue essential for fertility and implicated in many reproductive disorders. The tissue consists of glandular epithelium and vascularised stroma and is unique because it is constantly shed and regrown with each menstrual cycle, generating up to 10 mm of new mucosa. Consequently, there are marked changes in cell
Sally Mortlock, Brett McKinnon, Grant W. Montgomery   +2 more
openaire   +3 more sources

Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms

Вавиловский журнал генетики и селекции, 2021
Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases.
E. V. Ignatieva, E. A. Matrosova
doaj   +1 more source

Genetic Variation and the Control of Transcription

Cold Spring Harbor Symposia on Quantitative Biology, 2003
Identifying and understanding genetic variation is akey driver of agricultural, biotechnological, and biomedical research and commercialization; the major focus ofgenetic variation research has until now been on changesto protein-coding sequences because these are computationally and experimentally accessible.
Cotsapas, Chris, Chan, Eva, Kirk, Michael, Tanaka, Mark, Little, Peter   +4 more
openaire   +3 more sources

Global reference mapping of human transcription factor footprints

Nature, 2020
Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to ...
J. Vierstra, John T Lazar, R. Sandstrom, J. Halow, Kristen Lee, Daniel Bates, Morgan Diegel, D. Dunn, Fidencio J. Neri, E. Haugen, Eric Rynes, Alex P. Reynolds, Jemma Nelson, Audra K. Johnson, M. Frerker, Michael Buckley, R. Kaul, W. Meuleman, J. Stamatoyannopoulos   +18 more
semanticscholar   +1 more source

Transcriptional adaptation: a mechanism underlying genetic robustness [PDF]

Development, 2020
ABSTRACT Mutations play a crucial role in evolution as they provide the genetic variation that allows evolutionary change. Although some mutations in regulatory elements or coding regions can be beneficial, a large number of them disrupt gene function and reduce fitness. Organisms utilize several mechanisms to compensate for the damaging
Tamar E. Sztal, Didier Y. R. Stainier
openaire   +3 more sources

Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy

Medicine in Drug Discovery, 2022
PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages.
Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, Neel Sarovar Bhavesh   +3 more
doaj  

Comparación de los perfiles de transcripción de pacientes con fiebre de dengue y fiebre hemorrágica por dengue que muestra diferencias en la respuesta inmunitaria y claves en la inmunopatogénesis

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. El dengue puede manifestarse como una enfermedad leve o evolucionar hasta una enfermedad grave, llamada fiebre hemorrágica por dengue, cuyos mecanismos de inmunopatogénesis no son claros. Objetivo. Utilizar un análisis de microarreglos para
Natalia Houghton-Triviño, Katherine Martín, Kris Giaya, Jairo A. Rodríguez, Irene Bosch, Jaime E. Castellanos   +5 more
doaj   +1 more source

Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

Molecular biology and evolution, 2017
Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF ...
Yi Peng, Chao-ying Cui, Yaoxi He, Yaoxi He, Ouzhuluobu, Hui Zhang, Deying Yang, Qu Zhang, Bianbazhuoma, Lixin Yang, Yibo He, Yibo He, Kun Xiang, Xiaoming Zhang, S. Bhandari, P. Shi, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Yongyue Pan, Cirenyangji, Baimayangji, Gonggalanzi, Cai-juan Bai, Bianba, Basang, Ciwangsangbu, Shuhua Xu, Shuhua Xu, Hua Chen, Shiming Liu, Tianyi Wu, X. Qi, B. Su   +34 more
semanticscholar   +1 more source