Results 31 to 40 of about 5,008,846 (367)
The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
core +1 more source
Global reference mapping of human transcription factor footprints
Nature, 2020 Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to ...
J. Vierstra +18 more
semanticscholar +1 more source
Genetic Variation and the Control of Transcription
Cold Spring Harbor Symposia on Quantitative Biology, 2003 Identifying and understanding genetic variation is akey driver of agricultural, biotechnological, and biomedical research and commercialization; the major focus ofgenetic variation research has until now been on changesto protein-coding sequences because these are computationally and experimentally accessible.
Cotsapas, Chris +4 more
openaire +3 more sources
Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics [PDF]
, 2009 We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable.
Pierre-Emmanuel Morant +8 more
core +7 more sources
Transcriptional adaptation: a mechanism underlying genetic robustness [PDF]
Development, 2020 ABSTRACT Mutations play a crucial role in evolution as they provide the genetic variation that allows evolutionary change. Although some mutations in regulatory elements or coding regions can be beneficial, a large number of them disrupt gene function and reduce fitness. Organisms utilize several mechanisms to compensate for the damaging
Tamar E. Sztal, Didier Y. R. Stainier
openaire +3 more sources
Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy
Medicine in Drug Discovery, 2022 PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages.
Nupur Rani Agarwal +3 more
doaj
Biomédica: revista del Instituto Nacional de Salud, 2010 Introducción. El dengue puede manifestarse como una enfermedad leve o evolucionar hasta una enfermedad grave, llamada fiebre hemorrágica por dengue, cuyos mecanismos de inmunopatogénesis no son claros. Objetivo. Utilizar un análisis de microarreglos para
Natalia Houghton-Triviño +5 more
doaj +1 more source
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4 [PDF]
, 2019 Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its posttranscriptional fate.
Begley, Victoria Sarah +10 more
core +2 more sources
Effects of Replication and Transcription on DNA Structure-Related Genetic Instability
Genes, 2017 Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere ...
Guliang Wang, K. Vasquez
semanticscholar +1 more source
Optogenetics for transcriptional programming and genetic engineering
Trends in Genetics, 2022 Optogenetics combines genetics and biophotonics to enable noninvasive control of biological processes with high spatiotemporal precision. When engineered into protein machineries that govern the cellular information flow as depicted in the central dogma, multiple genetically encoded non-opsin photosensory modules have been harnessed to modulate gene ...
Tien-Hung Lan +3 more
openaire +2 more sources