Results 31 to 40 of about 4,501,017 (312)

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

Genes, 2017
Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere ...
Guliang Wang, K. Vasquez
semanticscholar   +1 more source

Genetic and Transcriptional Control of Bone Formation [PDF]

Oral and Maxillofacial Surgery Clinics of North America, 2010
An exquisite interplay of developmental cues, transcription factors, and coregulatory and signaling proteins support formation of skeletal elements of the jaw during embryogenesis and dynamic remodeling of alveolar bone in postnatal life. These molecules promote initial condensation of the mesenchyme, commitment of the mesenchymal progenitor to ...
Farah Y. Ghori, Haiyan Chen, Amjad Javed
openaire   +3 more sources

Optogenetics for transcriptional programming and genetic engineering

Trends in Genetics, 2022
Optogenetics combines genetics and biophotonics to enable noninvasive control of biological processes with high spatiotemporal precision. When engineered into protein machineries that govern the cellular information flow as depicted in the central dogma, multiple genetically encoded non-opsin photosensory modules have been harnessed to modulate gene ...
Tien-Hung Lan, Lian He, Yun Huang, Yubin Zhou   +3 more
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Fractional dynamics of globally slow transcription and its impact on deterministic genetic oscillation. [PDF]

PLoS ONE, 2012
In dynamical systems theory, a system which can be described by differential equations is called a continuous dynamical system. In studies on genetic oscillation, most deterministic models at early stage are usually built on ordinary differential ...
Kun Wei, Shilong Gao, Suchuan Zhong, Hong Ma   +3 more
doaj   +1 more source

Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies [PDF]

Frontiers in Cellular Neuroscience, 2020
Epilepsy is a common neurological disorder characterized by recurrent uncontrolled seizures and has an idiopathic "genetic" etiology or a symptomatic "acquired" component. Genetic studies have revealed that many epilepsy susceptibility genes encode ion channels, including voltage-gated sodium, potassium and calcium channels.
Karen M.J. van Loo, Albert J. Becker
openaire   +4 more sources

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

Genes & Development, 2016
Sansó et al. identified ∼100 putative substrates of human positive transcription elongation factor b (P-TEFb), which were enriched for proteins implicated in transcription and RNA catabolism.
M. Sansó, Rebecca S Levin, J. Lipp, V. Wang, A. K. Greifenberg, Elizabeth M Quezada, Akbar Ali, Animesh Ghosh, S. Larochelle, T. Rana, M. Geyer, L. Tong, K. Shokat, R. Fisher   +13 more
semanticscholar   +1 more source

Landscape of transcription in human cells

Nature, 2012
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali, Carrie A. Davis, A. Merkel, A. Dobin, T. Lassmann, A. Mortazavi, Andrea Tanzer, Julien Lagarde, Wei Lin, F. Schlesinger, Chenghai Xue, G. Marinov, Jainab Khatun, B. Williams, C. Zaleski, J. Rozowsky, M. Röder, F. Kokocinski, Rehab F Abdelhamid, T. Alioto, I. Antoshechkin, Michael T. Baer, Nadav S. Bar, P. Batut, K. Bell, I. Bell, S. Chakrabortty, Xian Chen, Jacqueline Chrast, João Curado, T. Derrien, J. Drenkow, E. Dumais, Jacqueline Dumais, R. Duttagupta, E. Falconnet, Meagan Fastuca, Katalin Fejes-Toth, Pedro G. Ferreira, S. Foissac, M. Fullwood, Hui Gao, David Gonzalez, Assaf Gordon, H. Gunawardena, C. Howald, Sonali Jha, Rory Johnson, P. Kapranov, Brandon King, C. Kingswood, O. J. Luo, Eddie Park, K. Persaud, Jonathan B. Preall, Paolo Ribeca, B. Risk, D. Robyr, M. Sammeth, Lorian Schaffer, L. See, Atif Shahab, Jørgen Skancke, A. Suzuki, Hazuki Takahashi, Hagen U. Tilgner, Diane Trout, Nathalie Walters, Huaien Wang, J. Wrobel, Yanbao Yu, Xiaoan Ruan, Y. Hayashizaki, J. Harrow, M. Gerstein, T. Hubbard, A. Reymond, S. Antonarakis, G. Hannon, Morgan C. Giddings, Y. Ruan, B. Wold, Piero Carninci, R. Guigó, T. Gingeras   +84 more
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Extraction and Characterization of Fucoidan Derived from Sargassum ilicifolium and Its Biomedical Potential with In Silico Molecular Docking

Applied Sciences, 2022
Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade.
Archana Lakshmanan, Balamuralikrishnan Balasubramanian, Viji Maluventhen, Arunkumar Malaisamy, Rathinasamy Baskaran, Wen-Chao Liu, Maruthupandian Arumugam   +6 more
doaj   +1 more source

Impact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomass

Scientific Reports, 2017
Cellulolytic enzymes capable of hydrolyzing plant biomass are secreted by microbial cells specifically in response to the carbon substrate present in the environment.
Nandita Pasari, Nidhi Adlakha, Mayank Gupta, Zeenat Bashir, Girish H. Rajacharya, Garima Verma, Manoj Munde, Rakesh Bhatnagar, Syed Shams Yazdani   +8 more
doaj   +1 more source

A Genetic Map of the Response to DNA Damage in Human Cells

Cell, 2019
The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 ...
Michele Olivieri, Michele Olivieri, Tiffany Cho, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, M. Schellenberg, Michal Zimmermann, Nicole Hustedt, S. Rossi, Salomé Adam, Henrique Melo, A. Heijink, Guillermo Sastre-Moreno, N. Moatti, R. Szilard, Andrea McEwan, Alexanda K. Ling, Almudena Serrano-Benitez, T. Ubhi, Sumin Feng, J. Pawling, Irene Delgado-Sainz, Michael W. Ferguson, J. Dennis, J. Dennis, Grant W. Brown, Felipe Cortés-Ledesma, R. S. Williams, Alberto Martin, Dongyi Xu, D. Durocher, D. Durocher   +32 more
semanticscholar   +1 more source