Results 41 to 50 of about 5,189,368 (329)

Genetic Variation and the Control of Transcription

Cold Spring Harbor Symposia on Quantitative Biology, 2003
Identifying and understanding genetic variation is akey driver of agricultural, biotechnological, and biomedical research and commercialization; the major focus ofgenetic variation research has until now been on changesto protein-coding sequences because these are computationally and experimentally accessible.
Cotsapas, Chris, Chan, Eva, Kirk, Michael, Tanaka, Mark, Little, Peter   +4 more
openaire   +2 more sources

Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions [PDF]

, 2005
Phenotypic robustness is evidenced when single-gene mutations do not result in an obvious phenotype. It has been suggested that such phenotypic stability results from 'buffering' activities of homologous genes as well as non-homologous genes acting in ...
Baugh, L. Ryan, Brown, Eugene L., Hill, Andrew A., Hunter, Craig P., Slonim, Donna K., Wen, Joanne C.   +5 more
core   +2 more sources

Landscape of transcription in human cells

Nature, 2012
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali, Carrie A. Davis, A. Merkel, A. Dobin, T. Lassmann, A. Mortazavi, Andrea Tanzer, Julien Lagarde, Wei Lin, F. Schlesinger, Chenghai Xue, G. Marinov, Jainab Khatun, B. Williams, C. Zaleski, J. Rozowsky, M. Röder, F. Kokocinski, Rehab F Abdelhamid, T. Alioto, I. Antoshechkin, Michael T. Baer, Nadav S. Bar, P. Batut, K. Bell, I. Bell, S. Chakrabortty, Xian Chen, Jacqueline Chrast, João Curado, T. Derrien, J. Drenkow, E. Dumais, Jacqueline Dumais, R. Duttagupta, E. Falconnet, Meagan Fastuca, Katalin Fejes-Toth, Pedro G. Ferreira, S. Foissac, M. Fullwood, Hui Gao, David Gonzalez, Assaf Gordon, H. Gunawardena, C. Howald, Sonali Jha, Rory Johnson, P. Kapranov, Brandon King, C. Kingswood, O. J. Luo, Eddie Park, K. Persaud, Jonathan B. Preall, Paolo Ribeca, B. Risk, D. Robyr, M. Sammeth, Lorian Schaffer, L. See, Atif Shahab, Jørgen Skancke, A. Suzuki, Hazuki Takahashi, Hagen U. Tilgner, Diane Trout, Nathalie Walters, Huaien Wang, J. Wrobel, Yanbao Yu, Xiaoan Ruan, Y. Hayashizaki, J. Harrow, M. Gerstein, T. Hubbard, A. Reymond, S. Antonarakis, G. Hannon, Morgan C. Giddings, Y. Ruan, B. Wold, Piero Carninci, R. Guigó, T. Gingeras   +84 more
semanticscholar   +1 more source

Genetic and Transcriptional Control of Bone Formation [PDF]

Oral and Maxillofacial Surgery Clinics of North America, 2010
An exquisite interplay of developmental cues, transcription factors, and coregulatory and signaling proteins support formation of skeletal elements of the jaw during embryogenesis and dynamic remodeling of alveolar bone in postnatal life. These molecules promote initial condensation of the mesenchyme, commitment of the mesenchymal progenitor to ...
Amjad, Javed, Haiyan, Chen, Farah Y, Ghori   +2 more
openaire   +2 more sources

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]

, 2019
This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia, Frugis, Giovanna, Giannino, Donato, Iannelli, Maria Adelaide, Mauro, Maria Luisa, Mele, Giovanni, Nicolodi, Chiara, Paolis, Angelo De, Rugini, Eddo, Silvestri, Cristian, Sparvoli, Francesca, Testone, Giulio   +11 more
core   +1 more source

Extraction and Characterization of Fucoidan Derived from Sargassum ilicifolium and Its Biomedical Potential with In Silico Molecular Docking

Applied Sciences, 2022
Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade.
Archana Lakshmanan, Balamuralikrishnan Balasubramanian, Viji Maluventhen, Arunkumar Malaisamy, Rathinasamy Baskaran, Wen-Chao Liu, Maruthupandian Arumugam   +6 more
doaj   +1 more source

A Genetic Map of the Response to DNA Damage in Human Cells

Cell, 2019
The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 ...
Michele Olivieri, Michele Olivieri, Tiffany Cho, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, M. Schellenberg, Michal Zimmermann, Nicole Hustedt, S. Rossi, Salomé Adam, Henrique Melo, A. Heijink, Guillermo Sastre-Moreno, N. Moatti, R. Szilard, Andrea McEwan, Alexanda K. Ling, Almudena Serrano-Benitez, T. Ubhi, Sumin Feng, J. Pawling, Irene Delgado-Sainz, Michael W. Ferguson, J. Dennis, J. Dennis, Grant W. Brown, Felipe Cortés-Ledesma, R. S. Williams, Alberto Martin, Dongyi Xu, D. Durocher, D. Durocher   +32 more
semanticscholar   +1 more source

Impact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomass

Scientific Reports, 2017
Cellulolytic enzymes capable of hydrolyzing plant biomass are secreted by microbial cells specifically in response to the carbon substrate present in the environment.
Nandita Pasari, Nidhi Adlakha, Mayank Gupta, Zeenat Bashir, Girish H. Rajacharya, Garima Verma, Manoj Munde, Rakesh Bhatnagar, Syed Shams Yazdani   +8 more
doaj   +1 more source

Embodied Computational Evolution: Feedback Between Development and Evolution in Simulated Biorobots

Frontiers in Robotics and AI, 2021
Given that selection removes genetic variance from evolving populations, thereby reducing exploration opportunities, it is important to find mechanisms that create genetic variation without the disruption of adapted genes and genomes caused by random ...
Joshua Hawthorne-Madell, Joshua Hawthorne-Madell, Eric Aaron, Eric Aaron, Ken Livingston, Ken Livingston, John H. Long, John H. Long   +7 more
doaj   +1 more source

Dinâmica ativa em sala de aula no ensino-aprendizado da transcrição gênica em ciências da saúde

Metodologias e Aprendizado, 2020
A metodologia ativa cria um ambiente propício para que o acadêmico tenha a possibilidade de ser resolutivo frente a um desafio, gerando o perfil profissional que está em consonância com as competências gerais dos profissionais da saúde.
Adroaldo Lunardelli, Denise Greff Machado   +1 more
doaj   +1 more source