Results 41 to 50 of about 5,231,452 (328)

Landscape of transcription in human cells

open access: yesNature, 2012
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali   +84 more
semanticscholar   +1 more source

Epigenetic aberrations and cancer [PDF]

open access: yes, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

open access: yesGenes & Development, 2016
Sansó et al. identified ∼100 putative substrates of human positive transcription elongation factor b (P-TEFb), which were enriched for proteins implicated in transcription and RNA catabolism.
M. Sansó   +13 more
semanticscholar   +1 more source

Genetic regulation of pituitary gland development in human and mouse [PDF]

open access: yes, 2009
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Aarskog   +321 more
core   +2 more sources

Extraction and Characterization of Fucoidan Derived from Sargassum ilicifolium and Its Biomedical Potential with In Silico Molecular Docking

open access: yesApplied Sciences, 2022
Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade.
Archana Lakshmanan   +6 more
doaj   +1 more source

Correlation analysis of the transcriptome of growing leaves with mature leaf parameters in a maize RIL population [PDF]

open access: yes, 2015
Background: To sustain the global requirements for food and renewable resources, unraveling the molecular networks underlying plant growth is becoming pivotal.
Baute, Joke   +9 more
core   +2 more sources

Impact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomass

open access: yesScientific Reports, 2017
Cellulolytic enzymes capable of hydrolyzing plant biomass are secreted by microbial cells specifically in response to the carbon substrate present in the environment.
Nandita Pasari   +8 more
doaj   +1 more source

A Genetic Map of the Response to DNA Damage in Human Cells

open access: yesCell, 2019
The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 ...
Michele Olivieri   +32 more
semanticscholar   +1 more source

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

open access: yes, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source

Embodied Computational Evolution: Feedback Between Development and Evolution in Simulated Biorobots

open access: yesFrontiers in Robotics and AI, 2021
Given that selection removes genetic variance from evolving populations, thereby reducing exploration opportunities, it is important to find mechanisms that create genetic variation without the disruption of adapted genes and genomes caused by random ...
Joshua Hawthorne-Madell   +7 more
doaj   +1 more source

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