Results 61 to 70 of about 5,231,452 (328)

Genetic and Transcriptional Control of Bone Formation [PDF]

Oral and Maxillofacial Surgery Clinics of North America, 2010
An exquisite interplay of developmental cues, transcription factors, and coregulatory and signaling proteins support formation of skeletal elements of the jaw during embryogenesis and dynamic remodeling of alveolar bone in postnatal life. These molecules promote initial condensation of the mesenchyme, commitment of the mesenchymal progenitor to ...
Amjad, Javed, Haiyan, Chen, Farah Y, Ghori   +2 more
openaire   +2 more sources

Wheat Breeding, Transcription Factories, and Genetic Interactions: New Perspectives

Frontiers in Plant Science, 2022
Epistatic interactions and negative heterosis have been shown to be associated with interchromosomal interactions in wheat. Physical gene-gene interactions between co-regulated genes clustered in “transcription factories” have been documented, and a ...
Richard B. Flavell
doaj   +1 more source

Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

Nature, 2014
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown.
K. Farh, K. Farh, A. Marson, Jiang Zhu, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld, William J. Housley, Samantha P. Beik, N. Shoresh, Holly J. Whitton, Russell J.H. Ryan, Russell J.H. Ryan, Alexander A. Shishkin, Alexander A. Shishkin, Meital Hatan, M. Carrasco-Alfonso, Dita Mayer, C. J. Luckey, N. Patsopoulos, N. Patsopoulos, Philip L. De Jager, Philip L. De Jager, V. Kuchroo, C. Epstein, M. J. Daly, M. J. Daly, David A. Hafler, David A. Hafler, B. Bernstein   +29 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

Nature Genetics, 2018
Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with ...
J. Harley, Xiaoting Chen, Mario Pujato, Daniel E. Miller, A. Maddox, Carmy Forney, A. Magnusen, A. Lynch, K. Chetal, M. Yukawa, A. Barski, N. Salomonis, K. Kaufman, Leah C. Kottyan, M. Weirauch   +14 more
semanticscholar   +1 more source

Effect of natural genetic variation on enhancer selection and function. [PDF]

, 2013
The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of ...
Allison, KA, Benner, C, Glass, CK, Heinz, S, Kaikkonen, MU, Orozco, LD, Romanoski, CE   +6 more
core  

Enhancement of the stability of genetic switches by overlapping upstream regulatory domains [PDF]

, 2003
We study genetic switches formed from pairs of mutually repressing operons. The switch stability is characterised by a well defined lifetime which grows sub-exponentially with the number of copies of the most-expressed transcription factor, in the regime
A. Arkin, D. T. Gillespie, M. Ptashne, R. Wagner, T. B. Kepler, W. Bialek, Z. Szallasi   +6 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genetic dissection of the RNA polymerase II transcription cycle

eLife, 2022
How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou, Adriana K Alexander, Edward J Rice, Lauren A Choate, Charles G Danko   +4 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source