Results 61 to 70 of about 5,008,846 (367)

Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. [PDF]

PLoS Biology, 2008
Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters within coding regions activate transcription in particular mutants.
Vanessa Cheung, Gordon Chua, Nizar N Batada, Christian R Landry, Stephen W Michnick, Timothy R Hughes, Fred Winston   +6 more
doaj   +1 more source

Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53 [PDF]

, 2010
Background: The availability of various "omics" datasets creates a prospect of performing the study of genome-wide genetic regulatory networks. However, one of the major challenges of using mathematical models to infer genetic regulation from microarray ...
A Chipperfield, A Conesa, AR Joyce, AT Kwon, AW Braithwaite, C Moorman, CG Moles, CL Wei, D Chen, DG Sedding, E Wingender, G Liu, H de Jong, J Aach, J Goutsias, J Goutsias, J Wang, J Wang, J Wang, J Wang, JC Liao, JM Espinosa, Junbai Wang, K Zhu, KB Spurgers, KH Vousden, L Ma, M Barenco, MK Yeung, MR Bhonde, MV Karamouzis, N Sun, PS Kho, Q Wei, Q Wu, R Rahman-Roblick, RB Zhao, RC Gentleman, RS Erb, S Liu, S Rogers, SA Johnson, T Tian, Tianhai Tian, TS Gardner, TT Vu, WS el Deiry   +46 more
core   +4 more sources

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

eLife, 2017
Many pancreatic transcription factors that are essential for islet cell differentiation have been well characterized; however, because they are often expressed in several different cell populations, their functional hierarchy remains unclear.
A. Churchill, Giselle Domínguez Gutiérrez, Ruth A Singer, David S. Lorberbaum, Kevin A Fischer, L. Sussel   +5 more
semanticscholar   +1 more source

Genetic Architecture of Transcript-Level Variation in Humans [PDF]

The American Journal of Human Genetics, 2008
We report here the results of testing the pairwise association of 12,747 transcriptional gene-expression values with more than two million single-nucleotide polymorphisms (SNPs) in samples of European (CEPH from Utah; CEU) and African (Yoruba from Ibadan; YRI) ancestry.
Wei Zhang, Tina X. Chen, M. Eileen Dolan, R. Stephanie Huang, Shiwei Duan, Anthony C. Schweitzer, Cheryl A. Roe, Tyson A. Clark, Wasim K. Bleibel, John E. Blume, Nancy J. Cox   +10 more
openaire   +3 more sources

Suppression and enhancement of transcriptional noise by DNA looping [PDF]

Phys. Rev. E 89, 062703 (2014), 2014
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping.
arxiv   +1 more source

Effect of natural genetic variation on enhancer selection and function. [PDF]

, 2013
The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of ...
Allison, KA, Benner, C, Glass, CK, Heinz, S, Kaikkonen, MU, Orozco, LD, Romanoski, CE   +6 more
core  

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Deciphering transcriptional dynamics in vivo by counting nascent RNA molecules [PDF]

, 2013
Transcription of genes is the focus of most forms of regulation of gene expression. Even though careful biochemical experimentation has revealed the molecular mechanisms of transcription initiation for a number of different promoters in vitro, the dynamics of this process in cells is still poorly understood.
arxiv   +1 more source

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

Nature Genetics, 2018
Explaining the genetics of many diseases is challenging because most associations localize to incompletely characterized regulatory regions. Using new computational methods, we show that transcription factors (TFs) occupy multiple loci associated with ...
J. Harley, Xiaoting Chen, Mario Pujato, Daniel E. Miller, A. Maddox, Carmy R. Forney, A. Magnusen, A. Lynch, K. Chetal, M. Yukawa, A. Barski, N. Salomonis, K. Kaufman, Leah C. Kottyan, M. Weirauch   +14 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source