Results 61 to 70 of about 4,501,017 (312)
Automated design of thousands of nonrepetitive parts for engineering stable genetic systems
Nature Biotechnology, 2020 Engineered genetic systems are prone to failure when their genetic parts contain repetitive sequences. Designing many nonrepetitive genetic parts with desired functionalities remains a difficult challenge with high computational complexity.
Ayaan Hossain +7 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
eLife, 2015 We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-
Romaric Bouveret +17 more
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Genetic mapping and transcriptional orientation of the fimD gene [PDF]
Journal of Bacteriology, 1983 Expression of type 1 fimbriae in Escherichia coli exhibits phase variation whereby individual cells can alternate between states of organelle expression and nonexpression. Strains carrying fim-lac operon fusions in which lac operon expression is under the control of a fim promoter undergo Lac+ in equilibrium Lac- phase variation. We have determined the
B I Eisenstein, C S Freitag
openaire +3 more sources
Evolutionary Bioinformatics, 2015 Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. The regulation of Hb F levels is influenced by transcription factors.
Gisele Cristine De Souza Carrocini +2 more
doaj +1 more source
eLife, 2015 A mutant transcription factor that has been linked to congenital heart disease has wider effects than previously thought.
Megan Rowton, Ivan P Moskowitz
doaj +1 more source
The Ultimate (Mis)match: When DNA Meets RNA
Cells, 2021 RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
doaj +1 more source
Nature Genetics, 2012 To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent.
Andrew P Benjamin F Tanya M Teresa Ayellet V Valgerdur Ro Morris Voight Teslovich Ferreira Segrè Steinthorsd +204 more
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source