Results 71 to 80 of about 5,008,846 (367)

The Ultimate (Mis)match: When DNA Meets RNA

Cells, 2021
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
doaj   +1 more source

The Functional Consequences of Variation in Transcription Factor Binding [PDF]

PLoS Genet 10(3) (2014) e1004226, 2013
One goal of human genetics is to understand how the information for precise and dynamic gene expression programs is encoded in the genome. The interactions of transcription factors (TFs) with DNA regulatory elements clearly play an important role in determining gene expression outputs, yet the regulatory logic underlying functional transcription factor
arxiv   +1 more source

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]

, 2016
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal, Guy, Clifford S, Kanneganti, Thirumala-Devi, Karki, Rajendra, Lamkanfi, Mohamed, Lupfer, Christopher, Malireddi, RK Subbarao, Man, Si Ming, Neale, Geoffrey, Qi, Xiaopeng   +9 more
core   +1 more source

Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants

Nature, 2014
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown.
K. Farh, K. Farh, A. Marson, Jiang Zhu, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld, William J. Housley, Samantha P. Beik, N. Shoresh, Holly J. Whitton, Russell J. H. Ryan, Russell J. H. Ryan, Alexander A. Shishkin, Alexander A. Shishkin, Meital Hatan, M. Carrasco-Alfonso, Dita Mayer, C. J. Luckey, N. Patsopoulos, N. Patsopoulos, P. Jager, P. Jager, V. Kuchroo, C. Epstein, M. J. Daly, M. J. Daly, D. Hafler, D. Hafler, B. Bernstein   +29 more
semanticscholar   +1 more source

The Genetics of Transcription Factor DNA Binding Variation [PDF]

Cell, 2016
Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key drivers of phenotypic variation.
Deplancke Bart, Alpern Daniel, Gardeux Vincent   +2 more
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Using network component analysis to dissect regulatory networks mediated by transcription factors in yeast.

PLoS Computational Biology, 2009
Understanding the relationship between genetic variation and gene expression is a central question in genetics. With the availability of data from high-throughput technologies such as ChIP-Chip, expression, and genotyping arrays, we can begin to not only
Chun Ye, Simon J Galbraith, James C Liao, Eleazar Eskin   +3 more
doaj   +1 more source

Wheat Breeding, Transcription Factories, and Genetic Interactions: New Perspectives

Frontiers in Plant Science, 2022
Epistatic interactions and negative heterosis have been shown to be associated with interchromosomal interactions in wheat. Physical gene-gene interactions between co-regulated genes clustered in “transcription factories” have been documented, and a ...
Richard B. Flavell
doaj   +1 more source

Transcriptional Similarity in Couples Reveals the Impact of Shared Environment and Lifestyle on Gene Regulation through Modified Cytosines [PDF]

, 2016
Gene expression is a complex and quantitative trait that is influenced by both genetic and non-genetic regulators including environmental factors. Evaluating the contribution of environment to gene expression regulation and identifying which genes are more likely to be influenced by environmental factors are important for understanding human complex ...
arxiv   +1 more source

Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate [PDF]

PLoS genetics, 14(3), e1007284 (2018), 2018
Cell growth is determined by substrate availability and the cell's metabolic capacity to assimilate substrates into building blocks. Metabolic genes that determine growth rate may interact synergistically or antagonistically, and can accelerate or slow growth, depending on the genetic background and environmental conditions. We evolved a diverse set of
arxiv   +1 more source