Results 71 to 80 of about 5,231,452 (328)

Epistatic relationships reveal the functional organization of yeast transcription factors

Molecular Systems Biology, 2010
The regulation of gene expression is, in large part, mediated by interplay between the general transcription factors (GTFs) that function to bring about the expression of many genes and site‐specific DNA‐binding transcription factors (STFs).
Jiashun Zheng, Joris J Benschop, Michael Shales, Patrick Kemmeren, Jack Greenblatt, Gerard Cagney, Frank Holstege, Hao Li, Nevan J Krogan   +8 more
doaj   +1 more source

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Nature Genetics, 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent.
Andrew P Benjamin F Tanya M Teresa Ayellet V Valgerdur Ro Morris Voight Teslovich Ferreira Segrè Steinthorsd, Andrew P. Morris, B. Voight, Tanya M. Teslovich, T. Ferreira, A. Segrè, V. Steinthorsdottir, R. Strawbridge, H. Khan, H. Grallert, A. Mahajan, I. Prokopenko, H. Kang, C. Dina, T. Esko, Ross M. Fraser, S. Kanoni, Ashish Kumar, V. Lagou, C. Langenberg, J. Luan, C. Lindgren, M. Müller-Nurasyid, S. Pechlivanis, N. W. Rayner, L. Scott, S. Wiltshire, L. Yengo, L. Kinnunen, E. Rossin, S. Raychaudhuri, Andrew D. Johnson, A. Dimas, R. Loos, S. Vedantam, Han Chen, J. Florez, C. Fox, Ching‐Ti Liu, Denis Rybin, D. Couper, W. Kao, Man Li, M. Cornelis, P. Kraft, Qi Sun, R. V. van Dam, H. Stringham, P. Chines, K. Fischer, P. Fontanillas, O. Holmen, S. Hunt, A. Jackson, A. Kong, R. Lawrence, Julia Meyer, J. Perry, Carl G. P. Platou, Simon C. Potter, E. Rehnberg, N. Robertson, S. Sivapalaratnam, A. Stančáková, K. Stirrups, G. Thorleifsson, E. Tikkanen, A. Wood, P. Almgren, M. Atalay, R. Benediktsson, L. Bonnycastle, N. Burtt, Jason P. Carey, G. Charpentier, A. Crenshaw, A. Doney, M. Dorkhan, S. Edkins, V. Emilsson, Elodie Eury, T. Forsén, K. Gertow, B. Gigante, George B. Grant, C. Groves, C. Guiducci, C. Herder, Á. Hreidarsson, J. Hui, A. James, A. Jonsson, W. Rathmann, N. Klopp, J. Kravic, K. Krjutškov, C. Langford, K. Leander, E. Lindholm, S. Lobbens, S. Männistö, G. Mirza, Thomas W. Mühleisen, B. Musk, Melissa Parkin, L. Rallidis, J. Saramies, B. Sennblad, Sonia H. Shah, G. Sigurðsson, A. Silveira, G. Steinbach, B. Thorand, J. Trakalo, F. Veglia, R. Wennauer, W. Winckler, D. Zabaneh, H. Campbell, C. V. van Duijn, A. Uitterlinden, A. Hofman, E. Sijbrands, G. Abecasis, K. Owen, E. Zeggini, M. Trip, N. Forouhi, A. Syvänen, J. Eriksson, L. Peltonen, M. Nöthen, B. Balkau, C. Palmer, V. Lyssenko, T. Tuomi, B. Isomaa, D. Hunter, L. Qi, A. Shuldiner, M. Roden, I. Barroso, T. Wilsgaard, J. Beilby, K. Hovingh, J. Price, James F. Wilson, R. Rauramaa, T. Lakka, L. Lind, G. Dedoussis, I. Njølstad, N. Pedersen, K. Khaw, N. Wareham, S. Keinanen-Kiukaanniemi, T. Saaristo, E. Korpi-Hyövälti, J. Saltevo, M. Laakso, J. Kuusisto, A. Metspalu, F. Collins, K. Mohlke, R. Bergman, J. Tuomilehto, B. Boehm, C. Gieger, K. Hveem, S. Cauchi, P. Froguel, D. Baldassarre, E. Tremoli, S. Humphries, D. Saleheen, J. Danesh, E. Ingelsson, S. Ripatti, V. Salomaa, R. Erbel, K. Jöckel, S. Moebus, A. Peters, T. Illig, U. de Faire, A. Hamsten, A. D. Morris, P. Donnelly, T. Frayling, A. Hattersley, E. Boerwinkle, O. Melander, S. Kathiresan, P. Nilsson, P. Deloukas, U. Thorsteinsdóttir, L. Groop, K. Stefánsson, F. Hu, J. Pankow, J. Dupuis, J. Meigs, D. Altshuler, M. Boehnke, M. McCarthy   +204 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Magnitude of Dyslipidemia and Factors Associated with Elevated LDL-C Among Black South Africans with Type 2 Diabetes Mellitus at a Tertiary Hospital

Obesities
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global public health challenge with a significant impact on human life. The current study aims to provide a comprehensive analysis of the magnitude of dyslipidemia and the factors ...
Mashudu Nemukula, Siphesihle Mkhwanazi, Tumelo Jessica Mapheto, Arun Kumar Malaisamy, Neel Sarovar Bhavesh, Olebogeng Harold Majane, Sechene Stanley Gololo   +6 more
doaj   +1 more source

Using network component analysis to dissect regulatory networks mediated by transcription factors in yeast.

PLoS Computational Biology, 2009
Understanding the relationship between genetic variation and gene expression is a central question in genetics. With the availability of data from high-throughput technologies such as ChIP-Chip, expression, and genotyping arrays, we can begin to not only
Chun Ye, Simon J Galbraith, James C Liao, Eleazar Eskin   +3 more
doaj   +1 more source

The Ultimate (Mis)match: When DNA Meets RNA

Cells, 2021
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
doaj   +1 more source

Rapidly Characterizing the Fast Dynamics of RNA Genetic Circuitry with Cell-Free Transcription–Translation (TX-TL) Systems

bioRxiv, 2014
RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or rewire existing ones. A potential strength of RNA networks is that they may be able to propagate signals on timescales that are set by the fast degradation rates of ...
Melissa K. Takahashi, James Chappell, Clarmyra A. Hayes, Zachary Z. Sun, Jongmin Kim, Vipul Singhal, Kevin J. Spring, Shaima Al-Khabouri, Christopher P. Fall, V. Noireaux, Richard M. Murray, Julius B. Lucks   +11 more
semanticscholar   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Automated design of thousands of nonrepetitive parts for engineering stable genetic systems

Nature Biotechnology, 2020
Engineered genetic systems are prone to failure when their genetic parts contain repetitive sequences. Designing many nonrepetitive genetic parts with desired functionalities remains a difficult challenge with high computational complexity.
Ayaan Hossain, Eriberto Lopez, Sean M. Halper, Daniel P. Cetnar, Alexander C. Reis, D. Strickland, E. Klavins, H. Salis   +7 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source