Results 81 to 90 of about 5,231,452 (328)

Probing marine macroalgal phlorotannins as an antibacterial candidate against Salmonella typhi: Molecular docking and dynamics simulation approach

Current Plant Biology
The increasing prevalence of drug-resistant bacterial strains, including multidrug-resistant Salmonella typhi, has raised significant concerns about the effectiveness of traditional antimicrobial treatments.
Arun Kumar Malaisamy, Balamuralikrishnan Balasubramanian, Pon Yazhine Tamilselvan, Venkatesh Sakthivel, Santhi Venkatachalapathi, Haripriya Kuchi Bhotla   +5 more
doaj   +1 more source

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

eLife, 2015
We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-
Romaric Bouveret, Ashley J Waardenberg, Nicole Schonrock, Mirana Ramialison, Tram Doan, Danielle de Jong, Antoine Bondue, Gurpreet Kaur, Stephanie Mohamed, Hananeh Fonoudi, Chiann-mun Chen, Merridee A Wouters, Shoumo Bhattacharya, Nicolas Plachta, Sally L Dunwoodie, Gavin Chapman, Cédric Blanpain, Richard P Harvey   +17 more
doaj   +1 more source

Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

bioRxiv, 2018
Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells.
Jeffrey M. Alexander, J. Guan, B. Huang, S. Lomvardas, O. Weiner   +4 more
semanticscholar   +1 more source

DNA repair: Disorders [PDF]

, 2010
No description ...
Bose, Burg, Caldecott, Chu, Digweed, Fernandez-Capetillo, Fousteri, Fousteri, Friedberg, Gudmundsdottir, Hashimoto, Hoeijmakers, Jiricny, Kraemer, Lavin, Lehmann, Lieber, Ma, Masutani, McCulloch, Meindl, Moldovan, Moshous, Nance, Nouspikel, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Rass, Stefanini, Stewart, Stracker, Taylor, Vaz, Wu, Zlatanou   +36 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Many ways to break a heart

eLife, 2015
A mutant transcription factor that has been linked to congenital heart disease has wider effects than previously thought.
Megan Rowton, Ivan P Moskowitz
doaj   +1 more source

The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin [PDF]

, 2015
Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC.
Dimude, JU, Foster, HA, Khan, A, Midgley-Smith, SL, Retkute, R, Rudolph, CJ, Saunders, NJ, Stockum, A, Upton, AL   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An integrative analysis of meningioma tumors reveals the determinant genes and pathways of malignant transformation

Frontiers in Oncology, 2014
Meningiomas are frequent central nervous system neoplasms which despite their predominant benignity, show sporadically malignant behaviour. Type 2 Neurofibromatosis and polymorphisms in several genes have been associated with meningioma risk and are ...
Adrián eMosquera Orgueira, José Carlos Iglesias Gómez   +1 more
doaj   +1 more source

Ancient mtDNA genetic variants modulate mtDNA transcription and replication. [PDF]

PLoS Genetics, 2009
Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the ...
Sarit Suissa, Zhibo Wang, Jason Poole, Sharine Wittkopp, Jeanette Feder, Timothy E Shutt, Douglas C Wallace, Gerald S Shadel, Dan Mishmar   +8 more
doaj   +1 more source