Results 81 to 90 of about 5,008,846 (367)

A Minimum Principle in Codon-Anticodon Interaction

, 2011
Imposing a minimum principle in the framework of the so called crystal basis model of the genetic code, we determine the structure of the minimum set of anticodons which allows the translational-transcription for animal mitochondrial code.
Sciarrino, A., Sorba, P.
core   +3 more sources

Automated design of thousands of nonrepetitive parts for engineering stable genetic systems

Nature Biotechnology, 2020
Engineered genetic systems are prone to failure when their genetic parts contain repetitive sequences. Designing many nonrepetitive genetic parts with desired functionalities remains a difficult challenge with high computational complexity.
Ayaan Hossain, Eriberto Lopez, Sean M. Halper, Daniel P. Cetnar, Alexander C. Reis, D. Strickland, E. Klavins, H. Salis   +7 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Epistatic relationships reveal the functional organization of yeast transcription factors

Molecular Systems Biology, 2010
The regulation of gene expression is, in large part, mediated by interplay between the general transcription factors (GTFs) that function to bring about the expression of many genes and site‐specific DNA‐binding transcription factors (STFs).
Jiashun Zheng, Joris J Benschop, Michael Shales, Patrick Kemmeren, Jack Greenblatt, Gerard Cagney, Frank Holstege, Hao Li, Nevan J Krogan   +8 more
doaj   +1 more source

Self-organization of gene regulatory network motifs enriched with short transcript's half-life transcription factors [PDF]

Trends Genet, 21:492-495, 2005, 2005
Network motifs, the recurring regulatory structural patterns in networks, are able to self-organize to produce networks. Three major motifs, feedforward loop, single input modules and bi-fan are found in gene regulatory networks. The large ratio of genes to transcription factors (TFs) in genomes leads to a sharing of TFs by motifs and is sufficient to ...
arxiv   +1 more source

Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]

, 2017
This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
core   +1 more source

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Nature Genetics, 2012
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent.
Andrew P Benjamin F Tanya M Teresa Ayellet V Valgerdur Ro Morris Voight Teslovich Ferreira Segrè Steinthorsd, Andrew P. Morris, B. Voight, Tanya M. Teslovich, T. Ferreira, A. Segrè, V. Steinthorsdottir, R. Strawbridge, H. Khan, H. Grallert, A. Mahajan, I. Prokopenko, H. Kang, C. Dina, T. Esko, Ross M. Fraser, S. Kanoni, Ashish Kumar, V. Lagou, C. Langenberg, J. Luan, C. Lindgren, M. Müller-Nurasyid, S. Pechlivanis, N. W. Rayner, L. Scott, S. Wiltshire, L. Yengo, L. Kinnunen, E. Rossin, S. Raychaudhuri, Andrew D. Johnson, A. Dimas, R. Loos, S. Vedantam, Han Chen, J. Florez, C. Fox, Ching‐Ti Liu, Denis Rybin, D. Couper, W. Kao, Man Li, M. Cornelis, P. Kraft, Qi Sun, R. V. van Dam, H. Stringham, P. Chines, K. Fischer, P. Fontanillas, O. Holmen, S. Hunt, A. Jackson, A. Kong, R. Lawrence, Julia Meyer, J. Perry, Carl G. P. Platou, Simon C. Potter, E. Rehnberg, N. Robertson, S. Sivapalaratnam, A. Stančáková, K. Stirrups, G. Thorleifsson, E. Tikkanen, A. Wood, P. Almgren, M. Atalay, R. Benediktsson, L. Bonnycastle, N. Burtt, Jason P. Carey, G. Charpentier, A. Crenshaw, A. Doney, M. Dorkhan, S. Edkins, V. Emilsson, Elodie Eury, T. Forsén, K. Gertow, B. Gigante, George B. Grant, C. Groves, C. Guiducci, C. Herder, Á. Hreidarsson, J. Hui, A. James, A. Jonsson, W. Rathmann, N. Klopp, J. Kravic, K. Krjutškov, C. Langford, K. Leander, E. Lindholm, S. Lobbens, S. Männistö, G. Mirza, Thomas W. Mühleisen, B. Musk, Melissa Parkin, L. Rallidis, J. Saramies, B. Sennblad, Sonia H. Shah, G. Sigurðsson, A. Silveira, G. Steinbach, B. Thorand, J. Trakalo, F. Veglia, R. Wennauer, W. Winckler, D. Zabaneh, H. Campbell, C. V. van Duijn, A. Uitterlinden, A. Hofman, E. Sijbrands, G. Abecasis, K. Owen, E. Zeggini, M. Trip, N. Forouhi, A. Syvänen, J. Eriksson, L. Peltonen, M. Nöthen, B. Balkau, C. Palmer, V. Lyssenko, T. Tuomi, B. Isomaa, D. Hunter, L. Qi, A. Shuldiner, M. Roden, I. Barroso, T. Wilsgaard, J. Beilby, K. Hovingh, J. Price, James F. Wilson, R. Rauramaa, T. Lakka, L. Lind, G. Dedoussis, I. Njølstad, N. Pedersen, K. Khaw, N. Wareham, S. Keinanen-Kiukaanniemi, T. Saaristo, E. Korpi-Hyövälti, J. Saltevo, M. Laakso, J. Kuusisto, A. Metspalu, F. Collins, K. Mohlke, R. Bergman, J. Tuomilehto, B. Boehm, C. Gieger, K. Hveem, S. Cauchi, P. Froguel, D. Baldassarre, E. Tremoli, S. Humphries, D. Saleheen, J. Danesh, E. Ingelsson, S. Ripatti, V. Salomaa, R. Erbel, K. Jöckel, S. Moebus, A. Peters, T. Illig, U. de Faire, A. Hamsten, Andrew D Morris, P. Donnelly, T. Frayling, A. Hattersley, E. Boerwinkle, O. Melander, S. Kathiresan, P. Nilsson, P. Deloukas, U. Thorsteinsdóttir, L. Groop, K. Stefánsson, F. Hu, J. Pankow, J. Dupuis, J. Meigs, D. Altshuler, M. Boehnke, M. McCarthy   +204 more
semanticscholar   +1 more source

Genetic mapping and transcriptional orientation of the fimD gene [PDF]

Journal of Bacteriology, 1983
Expression of type 1 fimbriae in Escherichia coli exhibits phase variation whereby individual cells can alternate between states of organelle expression and nonexpression. Strains carrying fim-lac operon fusions in which lac operon expression is under the control of a fim promoter undergo Lac+ in equilibrium Lac- phase variation. We have determined the
B I Eisenstein, C S Freitag
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

eLife, 2015
We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-
Romaric Bouveret, Ashley J Waardenberg, Nicole Schonrock, Mirana Ramialison, Tram Doan, Danielle de Jong, Antoine Bondue, Gurpreet Kaur, Stephanie Mohamed, Hananeh Fonoudi, Chiann-mun Chen, Merridee A Wouters, Shoumo Bhattacharya, Nicolas Plachta, Sally L Dunwoodie, Gavin Chapman, Cédric Blanpain, Richard P Harvey   +17 more
doaj   +1 more source