Results 81 to 90 of about 2,190,849 (297)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Toward structural understanding of eukaryotic transcription elongation

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Transcription is an essential biological process that underlies all cellular and organismal activities. In eukaryotes, RNA polymerase II (RNAPII) transcribes every protein-coding gene and many non-coding genes, playing a central role in gene expression ...
Shun-ichi SEKINE
doaj   +1 more source

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Cell Transplantation, 2013
A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes.
Rebecca A. Stokes, Kim Cheng, Natasha Deters, Sue Mei Lau, Wayne J. Hawthorne, Philip J. O'connell, Jessica Stolp, Shane Grey, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Frank J. Gonzalez, Jenny E. Gunton   +12 more
doaj   +1 more source

The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2019
Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action.
Amrutha Swaminathan, Amrutha Swaminathan, Moumita Basu, Abdelhamid Bekri, Abdelhamid Bekri, Pierre Drapeau, Pierre Drapeau, Tapas K. Kundu   +7 more
doaj   +1 more source

Dehydration responsive element binding transcription factors and their applications for the engineering of stress tolerance [PDF]

, 2017
Pradeep K. Agarwal, Kapil Gupta, Sergiy Lopato, Parinita Agarwal   +3 more
openalex   +1 more source

Transcriptional networking.

, 2005
A report on the European Science Foundation workshop 'Transcription Networks: A Global View', Madrid, Spain, 26-28 May 2005.
Teichmann, Sarah A, Bornberg-Bauer, Erich, Luscombe, Nicholas M   +2 more
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

eLife
Phosphoprotein phosphatase 1 (PP1) relies on association with PP1-interacting proteins (PIPs) to generate substrate-specific PIP/PP1 holoenzymes, but the lack of well-defined substrates has hindered elucidation of the mechanisms involved.
Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi, Stephane Mouilleron, Richard Treisman   +4 more
doaj   +1 more source