Results 31 to 40 of about 5,388 (199)

The Drosophila Homolog of Mammalian Zinc Finger Factor MTF-1 Activates Transcription in Response to Heavy Metals [PDF]

Molecular and Cellular Biology, 2001
Metallothioneins (MTs) are short, cysteine-rich proteins for heavy metal homeostasis and detoxification; they bind a variety of heavy metals and also act as radical scavengers. Transcription of mammalian MT genes is activated by heavy metal load via the metal-responsive transcription factor 1 (MTF-1), an essential zinc finger protein whose elimination ...
Bo Zhang, Dieter Egli, Oleg Georgiev, Walter Schaffner   +3 more
openalex   +4 more sources

Analysis of Cysteine and Histidine Residues Required for Zinc Response of the Transcription Factor Human MTF-1

Biological & Pharmaceutical Bulletin, 2015
Metal responsive element (MRE)-binding transcription factor-1 (MTF-1) is a zinc finger (ZF) transcription factor that plays a key role in heavy metal homeostasis by regulating relevant genes in response to metals. MTF-1 is known to be activated by heavy metals such as Zn and Cd, but the mechanism of activation remains unclear. In the present study, Cys
Kaoru Suzuki, Fuminori Otsuka, Hirotomo Yamada, Shinji Koizumi   +3 more
openalex   +4 more sources

A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1)

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I) and is also involved in the response to hypoxia and oxidative stress. MTF-1 recognizes a specific DNA sequence motif termed the metal response element (MRE), located in the promoter/enhancer ...
Viola Günther, Alisa M. Davis, Oleg Georgiev, Walter Schaffner   +3 more
openalex   +3 more sources

Advances in the role of membrane-bound transcription factors in carcinogenesis and therapy [PDF]

Discover Oncology
Protein shuttling between the cytoplasm and nucleus is a unique phenomenon in eukaryotic organisms, integral to various cellular functions. Membrane-bound transcription factors (MTFs), a specialized class of nucleocytoplasmic shuttling proteins, are ...
JiaLi Deng, Jie Zhou, BinYuan Jiang
doaj   +2 more sources

Differential Sensitivity of Zinc Finger Transcription Factors MTF-1, Sp1 and Krox-20 to CpG Methylation of Their Binding Sites [PDF]

Biological Chemistry Hoppe-Seyler, 1996
Cytosine methylation at CpG sites is often negatively correlated with mammalian gene activity. Many transcription factors whose DNA binding site contains one or more CpG dinucleotides are no longer able to efficiently bind DNA when the site is methylated. A notable exception is the zinc finger factor Sp1 which binds DNA and activates transcription even
Freddy Radtke, Martin J. Hug, Oleg Georgiev, Koichi Matsuo, Walter Schaffner   +4 more
openalex   +3 more sources

Regulation of Metallothionein Transcription by the Metal-responsive Transcription Factor MTF-1 [PDF]

Journal of Biological Chemistry, 2002
Nurten Saydam, Timothy K Adams, Florian Steiner, Walter Schaffner, Jonathan H. Freedman   +4 more
openalex   +3 more sources

A Multimodal Approach to Identify Metallothionein Metal Inducers in Nile Tilapia: Insights From Molecular Docking and Hepatocyte Exposure. [PDF]

J Appl Toxicol
ABSTRACT Many human activities contribute to the pollution of aquatic ecosystems, primarily through agricultural, industrial, mining, and domestic discharges into water bodies. Fish, being highly sensitive to environmental changes, serve as valuable models for monitoring the health of these ecosystems.
da Luz JZ, de Souza TL, de Almeida Roque A, de Marchi M, Pozzan R, Confortin C, Opuskevitch I, da Silva Ferreira FCA, de Oliveira Ribeiro CA, Neto FF.   +9 more
europepmc   +2 more sources

Ferroptosis-related gene MTF-1 as a novel prognostic biomarker in low-grade glioma and its correlation with immune infiltration

Heliyon, 2023
Background: Metal-responsive transcription factor-1 performs a necessary position in a range of cancers. It is unknown, though, how the prognosis of patients with low-grade gliomas is related to immune infiltration.
Huaixu Li, Xingliang Dai, Lv Zhou, Jianyu Nie, Hongwei Cheng, Peng Gao   +5 more
doaj   +1 more source

Mechanistic role of metal-responsive transcription factor-1 (MTF1) in cadmium-induced prostate carcinogenesis. [PDF]

Int J Biol Sci
Chandrasekaran B, Tyagi B, Tyagi A, Shukla V, Schatz M, Devanarayanan TN, Tyagi N, Damodaran C.   +7 more
europepmc   +3 more sources

Metal-Regulatory Transcription Factor-1 Targeted by miR-148a-3p Is Implicated in Human Hepatocellular Carcinoma Progression

Frontiers in Oncology, 2021
Metal-regulatory transcription factor-1 (MTF-1) is of importance in maintaining metal homeostasis. Copper exposure considerably stimulates the proliferation of hepatocellular carcinoma (HCC) cells with enhanced MTF-1 expression.
Zhuozhen Lyu, Mingyu Yang, Tan Yang, Mingze Ma, Zhen Yang   +4 more
doaj   +1 more source