Results 131 to 140 of about 736,695 (298)

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Genomewide Analysis of Clp1 Function in Transcription in Budding Yeast

Scientific Reports, 2017
In budding yeast, the 3′ end processing of mRNA and the coupled termination of transcription by RNAPII requires the CF IA complex. We have earlier demonstrated a role for the Clp1 subunit of this complex in termination and promoter-associated ...
Nadra Al-Husini, Ali Sharifi, Seyed Ahmad Mousavi, Hamidreza Chitsaz, Athar Ansari   +4 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Bacillus velezensis LoaP promotes antitermination by antagonizing NusA

mBio
The transcription factor NusG is essential for the bacterial transcription elongation complex (TEC). During elongation, NusG dynamically interacts with other proteins, affecting transcription-translation coupling, processivity, and termination.
Madison D. Jermain, Thao Tran, Conor C. Jenkins, Benjamin H. Nasisi, Wade C. Winkler   +4 more
doaj   +1 more source

Mechanism of catabolite repression in the bgl operon of Escherichia coli: involvement of the anti-terminator BglG, CRP - cAMP and $EIIA^G^L^c$ in mediating glucose effect downstream of transcription initiation

, 2000
Background: Expression of the bgl operon of Escherichia coli, involved in the regulated uptake and utilization of aromatic \beta-glucosides, is extremely sensitive to the presence of glucose in the growth medium.
Gulati, Abhilasha, Mahadevan, Subramony
core  

Terminator prevents displacement of Mcm2-7 ().

, 2019
G1-arrested SIR2 and sir2 strains with and without a CYC1 transcriptional terminator (red line marked with T) (strains 16855, 16895, 16905 and 16920 from left to right with 64, 85, 170 and 81 rDNA copies, respectively), inserted between the start of c ...
Tonibelle Gatbonton-Schwager (5707766), Uyen Lao (422297), David M. MacAlpine (242300), Antonio Bedalov (15251), Rafael Soriano (6694142), Erin Taylor (3741670), Eric J. Foss (206758), Adam H. Thiesen (6694139)   +7 more
core   +1 more source

Styles of Transcription in Ethnomusicology [PDF]

, 1996
Transcription has to do with the writing of musical sounds. In the field of ethnomusicology, transcription has long been considered as an important skill which should lead the ethnomusicologist toward the analysis of folk music, non-Western art music and
Ciantar, Philip
core  

A simple polypyrimidine repeat acts as an artificial Rho-dependent terminator in vivo and in vitro

, 1998
International audienceIn this paper, we present evidence that an efficient Rho-dependent terminator can be created by introducing a simple (AG/TC) n DNA repeat into a transcription unit.
Geiselmann, J., Robichon, N., Guerin, M, Rahmouni, A. Rachid   +3 more
core   +1 more source