Results 131 to 140 of about 71,371 (293)

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +2 more
core   +1 more source

Validation of a real-time polymerase chain reaction method for detecting the nopaline synthase terminator gene in milk-based matrices

Tạp chí Kiểm nghiệm và An toàn thực phẩm
The nopaline synthase terminator (T-nos) is a transcriptional termination sequence originally derived from the Ti (tumor-inducing) plasmid of Agrobacterium tumefaciens, a well-known soil bacterium capable of inducing crown gall disease in plants.
Dang Thi Huong, Pham Van Quan, Thieu Quang Thang, Pham Nhu Trong, Nguyen Thanh Trung   +4 more
doaj   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

The Measurement of rho‐independent Transcription Terminator Efficiency [PDF]

, 2012
The purpose of this RFC is to provide standard methodology for the measurement of the absolute strength of terminators in bacteria. Because we have characterized the performance of terminator in E.
Liu, Xianggeng, Qie, Boyu, Zhang, Mengshi, Shen, Liuxing, He, Jiankui, Jing, Shui, Wu, Zishan, Chen, Yao   +7 more
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Optimization of an L-rhamnose-inducible expression vector: test of various genetic module combinations-7

, 2011
Copyright information:Taken from "Optimization of an L-rhamnose-inducible expression vector: test of various genetic module combinations"http://www.biomedcentral.com/1472-6750/8/2BMC Biotechnology 2008;8():2-2.Published online 14 Jan 2008PMCID:PMC2254391.
Josef Altenbuchner (78460), Angelika Wegerer (78458), Tianqi Sun (78459)   +2 more
core   +1 more source

Insights on the effect of macromolecular crowding on transcription and its regulation

QRB Discovery
Transcription of DNA into RNA is a fundamental cellular process upon which life depends. It is tightly regulated in several different ways, and among the most important mechanisms are protein-induced topological changes in DNA such as looping.
Wenxuan Xu, Dylan Collette, Jin Qian, Laura Finzi, David Dunlap   +4 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

The role of a putative terminator region downstream of the txe gene.

, 2013
(A) E. coli SC301467 harbouring derivatives of pTE103 bearing the axe-txe cassette with (pat_axe-txe_ter) or without (pat_axe-txe) the putative downstream transcription terminator were grown at 370C. Absorbance readings at 600 nm were taken at 60 minutes
Lidia Boss (453343), Łukasz Labudda (453344), Barbara Kędzierska (5656177), Finbarr Hayes (453345), Grzegorz Węgrzyn (773048)   +4 more
core   +1 more source