Results 11 to 20 of about 5,966,093 (336)
Transcriptional activation: risky business [PDF]
Genes & Development, 2001 Transcriptional regulation is all about getting RNA polymerase to the right place on the gene at the right time and making sure that it is competent to conduct transcription. Traditional views of this process place most of their emphasis on the events that precede initiation of transcription.
Tansey, W. P.
openaire +4 more sources
Establishment of CRISPR‐STAR System to Realise Simultaneous Transcriptional Activation and Repression in Yarrowia lipolytica [PDF]
Microbial BiotechnologyThe ability to regulate gene expression in multiple directions is crucial to maximise the production of microbial cell factories. However, the lack of a regulatory tool that can simultaneously activate and repress multiple genes restricts the ...
Yaru Chen +8 more
doaj +2 more sources
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Rice, K.L. +4 more
core +4 more sources
Frontiers in Marine Science, 2022 Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated ...
Naina Hu +15 more
doaj +1 more source
Stress-induced transcriptional activation [PDF]
Microbiological Reviews, 1995 Living cells, both prokaryotic and eukaryotic, employ specific sensory and signalling systems to obtain and transmit information from their environment in order to adjust cellular metabolism, growth, and development to environmental alterations. Among external factors that trigger such molecular communications are nutrients, ions, drugs and other ...
Mager, W.H., de Kruijff, A.J.J.
openaire +3 more sources
Frontiers in Bioengineering and Biotechnology, 2022 The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption.
Xinchao Miao +11 more
doaj +1 more source
Generation of functional NaV1.5 current by endogenous transcriptional activation of SCN5A
Biotechnology & Biotechnological Equipment, 2021 The sodium channel NaV1.5, which is encoded by the SCN5A gene, underlies the fast upstroke of cardiac action potential and thus plays a crucial role in cardiac electrophysiology, but the mechanism governing the regulation of NaV1.5 has not been fully ...
Liang Xu, Rui Shi
doaj +1 more source
Genome-wide profiling of transcribed enhancers during macrophage activation
Epigenetics & Chromatin, 2017 Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13 ...
Elena Denisenko +5 more
doaj +1 more source
Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
openaire +2 more sources
Daytime temperature is sensed by phytochrome B in Arabidopsis through a transcriptional activator HEMERA. [PDF]
, 2019 Ambient temperature sensing by phytochrome B (PHYB) in Arabidopsis is thought to operate mainly at night. Here we show that PHYB plays an equally critical role in temperature sensing during the daytime.
Chen, Meng +4 more
core +3 more sources