Results 21 to 30 of about 5,966,093 (336)
Transcriptional activators in yeast [PDF]
Nucleic Acids Research, 2006 Eukaryotic transcription activation domains (ADs) are not well defined on the proteome scale. We systematicallly tested approximately 6000 yeast proteins for transcriptional activity using a yeast one-hybrid system and identified 451 transcriptional activators.
Titz, B. +5 more
openaire +3 more sources
The Two Sides of YY1 in Cancer: A Friend and a Foe
Frontiers in Oncology, 2019 Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair, autophagy, cell survival vs ...
Sailu Sarvagalla +2 more
doaj +1 more source
Recording transcriptional activity [PDF]
Nature Methods, 2018 Acquisition of RNA into CRISPR arrays allows the recording of transcriptional dynamics in cells.
openaire +2 more sources
Transcriptional regulation: Kamikaze activators [PDF]
Current Biology, 2000 Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.
Thomas, Dominique, Tyers, Mike
openaire +2 more sources
Long Non-Coding RNA Modulation of VEGF-A during Hypoxia
Non-Coding RNA, 2018 The role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic ...
Tiina Nieminen +5 more
doaj +1 more source
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]
, 2017 STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien +7 more
core +3 more sources
Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells [PDF]
, 2004 Because beta-catenin target genes such as cyclin D1 are involved in cell cycle progression, we examined whether beta-catenin has a more pervasive role in normal cell proliferation, even upon stimulation by non-Wnt ligands.
Asthagiri, Anand R., Graham, Nicholas A.
core +1 more source
Biomolecules, 2023 Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 (DYRK1) encodes a conserved protein kinase that is indispensable to neuron development.
Xiuke Ouyang +4 more
doaj +1 more source
Frontiers in Plant Science, 2021 Secondary wall-associated NAC (SWN) genes are a subgroup of NAC (NAM, ATAF, and CUC) transcription factors (TF) that play a key role in regulating secondary cell wall biosynthesis in plants.
Na Xu +7 more
doaj +1 more source
Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]
, 2016 Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki +7 more
core +1 more source