Results 31 to 40 of about 5,966,093 (336)

Molecular and cellular mechanisms of adipogenesis

Сахарный диабет, 2015
The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue.
Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk   +2 more
doaj   +1 more source

A mutant cell line partially responsive to both IFN-a and IFN-g [PDF]

Brazilian Journal of Medical and Biological Research, 1997
A recessive mutant cell line, B7, which is partially responsive to both interferon (IFN)- a and IFN-g is described. B7 was FACS sorted from a cellular pool, which was obtained from the parental cell line 2C4, after several rounds of mutagenesis.
C.A. Bonjardim
doaj   +1 more source

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity [PDF]

, 2017
MDM2–MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response, but their use in
A Plechanovová, A Plechanovová, Andreas K Hock, CS Chen, D Migliorini, D Shi, Danny T Huang, DC Scott, DE Christensen, Dominika Kowalczyk, E Branigan, E Meulmeester, Gary J Sibbet, H Dou, H Dou, H Kawai, H Kawai, I Ray-Coquard, J Momand, J Parant, JC Badciong, JD Oliner, JG Sanchez, JN Pruneda, K Itahana, K Linke, Karen H Vousden, KH Khoo, Koji Nomura, L Buetow, L Buetow, L Huang, LA Tollini, LC Storoni, LK Linares, LT Vassilev, M Andreeff, M Argentini, M Bista, M Kostic, Marta Klejnot, MG Koliopoulos, MHG Kubbutat, ML Choong, MS Dai, MS Dai, MV Poyurovsky, MW Jackson, N Minsky, N Zheng, P Dolezelova, P Emsley, P Roxburgh, PD Adams, PS Brzovic, Q Cheng, Q Cheng, Q Ding, R Honda, R Montes de Oca Luna, R Stad, R Stad, RA Finch, RK Geyer, S Iyappan, S Shangary, S Uldrijan, SN Jones, UM Moll, V Pant, W Kabsch, Y Pan   +71 more
core   +1 more source

Malignancy-Associated Regions of Transcriptional Activation: Gene Expression Profiling Identifies Common Chromosomal Regions of a Recurrent Transcriptional Activation in Human Prostate, Breast, Ovarian, and Colon Cancers

Neoplasia: An International Journal for Oncology Research, 2003
Despite remarkable advances in our understanding of a genetic basis of cancer, the precise molecular definition of the phenotypically relevant genetic features associated with human epithelial malignancies remains a significant and highly relevant ...
Gennadi V. Glinsky, Anja Krones-Herzig, Anna B. Glinskii   +2 more
doaj   +1 more source

Transcription Activation via Transcriptional Bursting [PDF]

Biophysical Journal, 2011
Transcription factors (TFs) often regulate their own expression; monitoring TF production in real time will help elucidate autoregulatory mechanisms. However, many TFs are expressed at low levels and are difficult to detect. Further, labeling TFs with fluorescent proteins risks disrupting their regulatory functions. Here, we report a novel strategy, Co-
Hensel, Zach, Feng, Haidong, Han, Bo, Hatem, Christine, Liu, Xuefang, Wang, Jin, Xiao, Jie   +6 more
openaire   +1 more source

Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression [PDF]

, 2008
Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family ...
Gabor, K., Oost, J., van der, Sene, K.H., Smidt, H., Vos, W.M., de   +4 more
core   +2 more sources

Transcriptional activity by cocaine–amphetamine-regulated transcript [PDF]

Molecular Psychiatry, 2007
Cocaine–amphetamine-regulated transcript (CART) gene was identified in 1995 in a search for mRNAs in the striatum acutely upregulated by psychostimulants.1 CART is highest expressed in the hypothalamus and widely expressed in the central and peripheral nervous systems, as well as in endocrine cells.1, 2 CART peptides have received much attention as ...
P, Mao, R, Jacks
openaire   +2 more sources

Cathepsins as Transcriptional Activators? [PDF]

Developmental Cell, 2004
One action of proteases is limited cleavage of latent transcription factors, releasing active factors to initiate nuclear signaling. Goulet et al., in a recent Molecular Cell paper, provide evidence that a lysosomal protease, cathepsin L, exists in a previously unsuspected isoform capable of trafficking to the nucleus and activating the CDP/Cux ...
openaire   +2 more sources

Co‐activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors [PDF]

Journal of Cellular Biochemistry, 2009
AbstractRunx proteins are essential for a number of developmental processes and are aberrantly expressed in many human cancers. Runx factors bind DNA and co‐factors to activate or repress genes crucial for bone formation, hematopoiesis, and neuronal development.
Xiaodong, Li, Luke H, Hoeppner, Eric D, Jensen, Rajaram, Gopalakrishnan, Jennifer J, Westendorf   +4 more
openaire   +2 more sources

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources