Results 61 to 70 of about 5,966,093 (336)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Gut and LiverBackground/Aims: Gastric intestinal metaplasia (GIM), a common precancerous lesion of gastric cancer, can be caused by bile acid reflux. GATA binding protein 4 (GATA4) is an intestinal transcription factor involved in the progression of gastric cancer ...
Xiaofang Yang +7 more
doaj +1 more source
Targeted Reactivation of FMR1 Transcription in Fragile X Syndrome Embryonic Stem Cells
Frontiers in Molecular Neuroscience, 2018 Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the 5′ untranslated region (UTR) of FMR1.
Jill M. Haenfler +9 more
doaj +1 more source
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Cell, 2019 Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional response to ferroptotic stimuli is unknown.
I. Alim +4 more
semanticscholar +1 more source
Activating transcription factor 4
The International Journal of Biochemistry & Cell Biology, 2008 Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals
Ameri, K, Harris, A
openaire +3 more sources
Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]
, 2017 The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca +12 more
core +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
GATA3 Regulates the Development and Functions of Innate Lymphoid Cell Subsets at Multiple Stages
Frontiers in Immunology, 2017 Innate lymphoid cells (ILCs) are regarded as the innate counterpart of effector CD4 T helper (Th) cells. Just as Th cells, ILCs are classified into distinct subsets based on their functions that are delivered mainly through effector cytokine production ...
Jinfang Zhu
doaj +1 more source
The role of Nrf2 in astragaloside IV-mediated antioxidative protection on heart failure
Pharmaceutical Biology, 2020 Context Heart failure is one of the most serious diseases worldwide. Astragaloside IV (ASI) is widely used in the treatment of cardiovascular diseases.
Yan-Bo Sui +4 more
doaj +1 more source
Rethinking Transcriptional Activation in the Arabidopsis Circadian Clock
PLoS Comput. Biol., 2014 Circadian clocks are biological timekeepers that allow living cells to time their activity in anticipation of predictable daily changes in light and other environmental factors. The complexity of the circadian clock in higher plants makes it difficult to
Karl Fogelmark, C. Troein
semanticscholar +1 more source