Results 91 to 100 of about 40,064,733 (237)

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D., Marjo-Riitta Jarvelin, Coin, Lachlan, Matthew A. Brown (131482), Ferreira, Manuel, O'Connor, George T, Guy B Marks, Dharmage, Shyamali C, Adaikalavan Ramasamy (4841), Anneli Pouta, Lehtimäki Terho, Tari Haahtela, Veikko Salomaa (62543), Shyamali C. Dharmage, Manuel A R Ferreira, Lehtimaki, Terho, Anneli Pouta (116626), Pekkanen Juha, Joel N Hirschhorn, Gajdos, Zofia K, Strachan David P., Palotie Aarno, Colin F. Robertson (131511), Philip J Thompson, Lehtimäki, T, Montgomery, Grant, Andrew C. Heath, Duffy David L., Strachan, David P, Elisabeth Widen (75580), Matthias Wjst (56613), Thompson, Philip, David L. Duffy (131489), Martin, Nicholas G., Laitinen, Tarja, Hirschhorn, Joel, Raitakari, Olli T, Alexessander Couto Alves, Tarja Laitinen, Lyon, Helen, Wareham, Nick, Laitinen Tarja, Palmer, CD, Raitakari Olli T., Peter Le Souef, Christer Janson, Vedantam, Sailaja, Janson Christer, Sailaja Vedantam (131467), George T. O'Connor (110263), Marks Guy B., Ramasamy, Adaikalavan, Ferreira, Manuel AR, Andrew C Heath, Peter Le Souef (131503), David P Strachan, Palotie, Aarno, Eriksson, Johan, Jing Hua Zhao (73808), Jorma Viikari, Tari Haahtela (131492), Nick Wareham, Grant W. Montgomery (131518), Heathe, Andrew C, Khaw, KT, Nicholas G. Martin (113568), Jarvelin, Marjo-Riitta, Robertson, CF, Mika Kähönen (131499), Michael J. Abramson, Matheson, M C, Kay-Tee Khaw, Pouta, Anneli, David P. Strachan, Abramson, Michael J, Manuel A. R. Ferreira, Aarno Palotie (41342), Juha Pekkanen (27303), Palotie, A, Mikko Kuokkanen, Ferreira, MA, Marks, Guy B., Helen N Lyon, Philip J. Thompson (131523), Cameron D Palmer, Deborah L. Jarvis (131514), Thompson, Philip J., Colin F. Robertson, Janson, Christer,, Heath, Andrew C, Madden, Pamela AF, Kuokkanen Mikko, Strachan, David P., Salomaa, Veikko, Jaana Laitinen (116629), Coin, L, Haahtela, T, Widen Elisabeth, Ramasamy, A, Martin, NG, Janson, C, Madden, PA, Eriksson, J, Laitinen Jaana, Thompson Philip J., Couto Alves, A, Matheson, Melanie C, Australian Asthma Genetics, Martin Nicholas G., ?, ?, Salomaa, V, Zhao, Jing Hua, Olli T Raitakari, Palmer, Cameron D, David L Duffy, Jarvis Deborah L., Palmer, Cameron, Widen, Elizabeth, Zofia K. Gajdos (131468), Matheson, Melanie C., Widen, Elisabeth, O'Connor George T., Martin, Nicholas, Raitakari, OT, O'Connor, George, Kähönen Mika, Colin F Robertson, O'Connor, GT, Kähönen, M, Gajdos, Zofia, Duffy, David L., Lachlan Coin (3863), Jarvelin Marjo-Riitta, Dharmage Shyamali C., Dharmage, Shyamali C., Raitakari, Olli T., Jousilahti, P, Hirschhorn Joel N., Pekka Jousilahti, Ferreira Manuel A. R., Lyon, Helen N., Guy B. Marks (116572), Martin, Nicholas G, Nicholas G Martin, Brown, MA, Marks, Guy, Michael J. Abramson (131480), Pekkanen, Juha, Lyon, HN, Matheson Melanie C., Pekkanen, J, Madden Pamela A. F., Duffy, DL, Heath, AC, Gajdos Zofia K., Olli T. Raitakari (115559), Lachlan Coin, Lyon, Helen N, Camerond Palmer, Nicholas G. Martin, Strachan, David, Jousilahti Pekka, Jousilahti, Pekka, Dharmage, Shyamali, Pamela A. F. Madden (127156), Veikko Salomaa, Madden, Pamela, Wjst Matthias, Zofia K. Gajdos, Marks, GB, Matthew A Brown, Manuel A. R. Ferreira (131476), Khaw, Kay-Tee, Jarvis, Deborah L., Kahonen, Mika, Montgomery, GW, Montgomery, Grant W, Eriksson Johan, Pouta, A, Viikari, J, Heath Andrew C., Johan Eriksson, Shyamali C. Dharmage (131486), Laitinen, T, Laitinen, J, Johan Eriksson (131534), Pekka Jousilahti (131538), David L. Duffy, Palmer, Cameron D., Palmer, Cameron Douglas, George T O'Connor, Duffy, David, Viikari, E, Jaana Laitinen, Kay-Tee Khaw (110271), Viikari Jorma, Matheson, MC, Mikko Kuokkanen (131465), Khaw Kay-Tee, Matthew A. Brown, Thompson, Philip J, Montgomery Grant W., Le Souef, P, Robertson, Colin, Jarvis, Debbie, Mika Kähönen, Pamela A F Madden, Melanie C Matheson, Pouta Anneli, Alexessander Couto Alves (131470), Andrew C. Heath (127152), Tarja Laitinen (131542), George T. O’connor, Viikari, Jorma, Aarno Palotie, O'Connor, George T., Melanie C. Matheson (131507), Lyon Helen N., Marks, Guy B, Joel N. Hirschhorn, Ramasamy Adaikalavan, Terho Lehtimäki (49739), Juha Pekkanen, Marjo-Riitta Jarvelin (110290), Heathe, Andrew, Abramson Michael J., Heath, Andrew C., Wareham Nick, Gajdos, ZK, Zhao, Jing, Brown, Matthew A, Deborah L. Jarvis, Matheson, M, Abramson, Michael, Michael J Abramson, Christer Janson (83414), Jarvelin, MR, Adaikalavan Ramasamy, Duffy, David L, Jing Hua Zhao, Zhao Jing Hua, Jorma Viikari (49741), Montgomery, Grant W., Brown, Matthew A., Vedantam Sailaja, Robertson Colin F., Wjst, Matthias, Cameron D. Palmer (131509), David P. Strachan (110302), Hirschhorn, Joel N., Ferreira, Manuel A. R., Er Couto Alves, Thompson, PJ, Raitakari, Olli, Brown, Matthew, Laitinen, Jaana, Haahtela Tari, Grant W Montgomery, Brown Matthew A., Alves, Alexessander Couto, Robertson, Colin F., Matthias Wjst, Olli T. Raitakari, Zhao, JH, Couto Alves, Alexessander, Shyamali C Dharmage, Melanie C. Matheson, Gajdos, Zofia K., Kuokkanen, M, Widen, E, Hirschhorn, Joel N, Salomaa Veikko, Deborah L Jarvis, Janson, Christer, Guyb. Marks, Le Souef, Peter, Le Souef Peter, Wareham, N, Haahtela, Tari, Kuokkanen, Mikko, Hirschhorn, JN, Vedantam, S, Dharmage, SC, Jarvis, DL, Jarvis, Deborah L, Couto Alves Alexessander, Strachan, DP, Nick Wareham (131528), Pamela A. F. Madden, Abramson, MJ, Coin Lachlan, Elisabeth Widen, Madden, Pamela A, Zofia K Gajdos, Wjst, M, Sailaja Vedantam, Grant W. Montgomery, Robertson, Colin F, Philip J. Thompson, Helen N. Lyon (131473), Australian Asthma Genetics Consortium Collaborators, Abramson, Michael J., Joel N. Hirschhorn (131545), Terho Lehtimäki, Helen N. Lyon, Madden, Pamela A. F., Strachan, D. P., Jousilahti, P., Raitakari, O. T., Thompson, P. J., Lehtimäki, T., Salomaa, V., Dharmage, S. C., Montgomery, G. W., Widen, E., Gajdos, Z. K., O'Connor, G. T., Couto Alves, A., Eriksson, J., Laitinen, T., Vedantam, S., Haahtela, T., Heath, A. C., et al,, et al., Pouta, A., Hirschhorn, J. N., Abramson, M. J., Palotie, A., Duffy, D. L., Viikari, J., Jarvelin, M. R., Kähönen, M., Brown, Matthew. A., Wjst, M., Kuokkanen, M., Coin, L., Lyon, H. N., Matheson, M. C., Palmer, C. D., Khaw, K. T., Ferreira, M. A. R., Le Souef, P., Martin, N. G., Robertson, C. F., Wareham, N., Janson, C., Pekkanen, J., Madden, P. A. F., Zhao, J. H., Jarvis, D. L., Laitinen, J., Marks, G. B., Ramasamy, A.   +353 more
core   +3 more sources

Genome- and transcriptome-wide association studies reveal the genetic basis of seed palmitic acid content in Brassica napus

Journal of Integrative Agriculture
Rapeseed (Brassica napus L.) is one of the most important oilseed crops worldwide, and the development of rapeseed varieties with high-quality oil is a long-term breeding goal.
Haijiang Liu, Yongheng Yuan, Yunshan Tang, Ruoshui Li, Kaijie Ye, Mengzhen Zhang, Kun Lu, Nengwen Yin, Huiyan Zhao, Yuanyuan Liu, Taocui Huang, Rui Wang, Lei Shi, Hai Du, Cunmin Qu   +14 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Evaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]

, 2010
Background Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.
Tomlinson, IP, Mann, GJ, Hwang, Shih-Jen, Hopper, John L., Hwang, SJ, Amos, CI, Barkardottir, Rosa B., McCarthy, Mark I, Carvajal-Carmona Luis, Albanes, D, Xu, J, Armstrong, Bruce K., Kenneth Muir, Stefansson Kari, Jacobs, EJ, Amos Christopher I., Zanke, B, Barkardottir, Rosa B, Jenab, M, Michaud, DS, Xu Jianfeng, Mendelsohn, JB, Muir, K, Hamdy, Freddie C., Stolzenberg-Solomon, RZ, Aitken, JF, Mathieu Lemire, Aitken, Joanne F., John P. A. Ioannidis, null null, Hunter, David, Hallmans, G, Donovan, Jenny L, Murabito Joanne M., Risch, HA, Hamdy, FC, Rafnar Thorunn, Giles, Graham G., Donovan, JL, Tomlinson, Ian P. M., Hunter David J., Margaret R Spitz, Macgregor, Stuart, Tomlinson Ian P. M., Spitz, Margaret R., Hopper, JL, David E. Neal, Duell, EJ, Stefansson, K, Simon N Stacey, Gudbjartsson, Daniel F, Julius Gudmundsson, David J Hunter, Armstrong, BK, Neal David E., Easton Douglas F., Amundadottir, L, Kari Stefansson, Stephen J Chanock, Hayward Nicholas K., Zeggini, E, Neal, David E, Isaacs, William B, Easton, DF, Chanock, Stephen J, Patel, AV, Douglas F. Easton, Brown Kevin M., Petersen, GM, Thorlacius, Steinunn, Isaacs, William B., William B Isaacs, Gallinger, S, Klein, AP, Gaborieau Valerie, Donovan, Jenny, Kraft, P, Kevin M Brown, Giovannucci, EL, Holly, EA, Lemire, Mathieu, Rosa B. Barkardottir, Sulem, P, Barkardottir, RB, Neal, David E., Zeggini, Eleftheria, Valerie Gaborieau, Chanock, Stephen J., Kevin M. Brown, Zeggini Eleftheria, Barkardottir, Rosa, HASH(0x55a67fc6f008), Riboli, E, Hayward, NK, Shu, XO, Howard, B, David E Neal, Stacey, Simon N., Gronberg, H, PanScan, C, Parikh, H, Gudmundsson Julius, Hassan, M, Ian P. M. Tomlinson, Tomlinson, IPM, Ioannidis, JPA, Gudmundsson, Julius, Carvajal-Carmona, Luis, McCarthy, MI, Kefford, Richard F., Clipp, S, McCarthy Mark I., Donovan Jenny L., Brent Zanke, Muir, Kenneth, Neal, DE, Ioannidis, John P., Li, D, Amundadottir Laufey, Canzian, F, Eeles, RA, Rodriguez, L, Gudmundsson, J, Mark I. McCarthy, Xu, Jianfeng, Elliott, Katherine S, Hutchinson, A, Krogh, V, Mann, Graham J., Thomas, G, Ioannidis, John PA, Eeles Rosalind A., Brown, Kevin M., Stacey, SN, Ioannidis, John, Kefford, RF, Sulem, Patrick, Katherine S Elliott, Gudbjartsson Daniel F., Murabito, JM, Stacey Simon N., McCarthy, Mark I., Gudbjartsson, DF, Hamdy Freddie C., Jenny L. Donovan, Eleftheria Zeggini, Hunter, David J., Luis Carvajal-Carmona, Chanock, Stephen, Hayward, Nicholas K., Michael Gaziano, J, Hunter, David J, Shih-Jen Hwang, Jianfeng Xu, The PanScan Consortium, Buring, JE, Amos, Christopher I, Henrik Grönberg, PanScan Consortium, Giles, GG, Rafnar, Thorunn, Easton, Douglas F, Nicholas K. Hayward, Brown, KM, Chanock Stephen J., Jenny L Donovan, Rosalind A Eeles, Arslan, AA, Seminara, D, Goggins, M, Stefansson, Kari, Murabito, Joanne M., Hunter, DJ, McCarthy, Mark, Tomlinson, Ian PM, Donovan, Jenny L., Rajkovic, A, Zanke Brent, Hamdy, Freddie C, Nicholas K Hayward, Thorlacius Steinunn, Hayward, Nicholas K, Joanne M. Murabito, Lynch, SM, Isaacs William B., Daniel F. Gudbjartsson, Elliott, Katherine S., Ioannidis, John P. A., Fuchs, CS, de Andrade, M, Hankinson, SE, Grönberg Henrik, Lemire Mathieu, Christopher I. Amos, Gross, M, Mandelson, MT, Spitz, Margaret R, Ioannidis, John P.A., Helzlsouer, K, Laufey Amundadottir, Bracci, PM, Tomlinson, Ian, Kooperberg, C, Kurtz, RC, Grönberg, H, John P A Ioannidis, Sulem Patrick, Eeles, Rosalind A, McWilliams, RR, Gaborieau, V, Elliott Katherine S., Ioannidis, JP, Christopher I Amos, Tjønneland, A, Stuart Macgregor, Rosalind A. Eeles, Berg, CD, Rosa B Barkardottir, Joanne M Murabito, Isaacs, WB, Elliott, KS, Bamlet, WR, Freddie C. Hamdy, Macgregor, S, Freddie C Hamdy, Grönberg, Henrik, Carvajal-Carmona, L, Gaborieau, Valerie, Easton, Douglas F., Lemire, M, Rafnar, T, Simon N. Stacey, Olson, SH, Amundadottir, Laufey, Chanock, SJ, Cotterchio, M, Muir Kenneth, Stephen J. Chanock, Australian Melanoma Family Study Investigators, Ioannidis John P. A., Margaret R. Spitz, Thorlacius, S, Stacey, Simon N, Tomlinson, Ian P M, Spitz Margaret R., Ioannidis, John P A, Brennan Paul, Steinunn Thorlacius, Mark I McCarthy, Lacroix, A, Paul Brennan, David J. Hunter, Patrick Sulem, William B. Isaacs, Brennan, P, Hwang Shih-Jen, Brown, Kevin M, Douglas F Easton, Daniel F Gudbjartsson, Zheng, W, Katherine S. Elliott, Gudbjartsson, Daniel Fannar, Thorunn Rafnar, Bas Bueno-De-Mesquita, H, Hamdy, Freddie, Boutron-Ruault, MC, Gudbjartsson, Daniel F., Tomlinson, Ian P.M., Zanke, Brent, Macgregor Stuart, Barkardottir Rosa B., Amos, Christopher I., Murabito, Joanne M, Jacobs, KB, Australian, MFSI, Brennan, Paul, Peeters, PHM, Spitz, MR, Kaaks, R, Eeles, Rosalind A., Ian P M Tomlinson   +280 more
core   +1 more source

TIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation

Journal of Inflammation Research
Qingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...
Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X   +10 more
doaj  

Multi-ethnic transcriptome-wide association study of prostate cancer.

PLoS ONE, 2020
The genetic risk for prostate cancer has been governed by a few rare variants with high penetrance and over 150 commonly occurring variants with lower impact on risk; however, most of these variants have been identified in studies containing exclusively ...
Peter N Fiorica, Ryan Schubert, John D Morris, Mohammed Abdul Sami, Heather E Wheeler   +4 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Abstract 1321: Transcriptome-wide association study of prostate cancer risk

, 2017
Though more than 150 single nucleotide polymorphisms (SNPs) associated with prostate cancer have been identified through GWAS, we still do not understand the functional consequences of common genetic variation in this disease.
Kathryn L. Penney, Maxine Chen, null null, Peter Kraft, Alexander Gusev, Massimo Loda, Lorelei A. Mucci, Meir J. Stampfer   +7 more
core   +1 more source

A genome-wide association study and transcriptome analysis reveal the genetic basis for the Southern corn rust resistance in maize

Journal of Integrative Agriculture
Southern corn rust (SCR) is an airborne fungal disease caused by Puccinia polysora Underw. (P. polysora) that adversely impacts maize quality and yields worldwide.
Yang Wang, Chunhua Mu, Xiangdong Li, Canxing Duan, Jianjun Wang, Xin Lu, Wangshu Li, Zhennan Xu, Shufeng Sun, Ao Zhang, Zhiqiang Zhou, Shenghui Wen, Zhuanfang Hao, Jienan Han, Jianzhou Qu, Wanli Du, Fenghai Li, Jianfeng Weng   +17 more
doaj   +1 more source