Results 71 to 80 of about 41,997,714 (232)
, 2023 This item includes all codes for "Genome- and transcriptome-wide association studies to discover candidate genes for diverse root phenotypes in cultivated rice". The statistical methods are described in the manuscript.
Ryokei Tanaka (16960911)
core +1 more source
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]
, 2018 Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Hyejung Won +54 more
core +4 more sources
Genetic insights into the dissolution of dioecy in diploid persimmon Diospyros oleifera Cheng
BMC Plant Biology, 2023 Background Dioecy, a sexual system of single-sexual (gynoecious/androecious) individuals, is rare in flowering plants. This rarity may be a result of the frequent transition from dioecy into systems with co-sexual individuals.
Peng Sun +14 more
doaj +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]
Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most of the ...
Liu, Yongmei +21 more
core +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
, 2020 Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations ...
A Cox (65204) +100 more
core
, 2023 Gene expression prediction model - 49 Genotype-Tissue Expression (GTEx, v8) tissues. More details about the models could be found in Methods "Transcriptome-wide association studies across 49 human cell-types and tissues" in paper "Genetic imputation of ...
Xiaoguang Xu (17666223)
core +1 more source
Scientific ReportsChronic widespread musculoskeletal pain (CWP), a core symptom of fibromyalgia, is a complex condition with an unclear pathogenesis. Despite findings from genome-wide association studies (GWAS), translating genetic risk variants into therapeutic targets ...
Zhisen Dai +3 more
doaj +1 more source