Results 81 to 90 of about 40,064,733 (237)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. [Elektronisk resurs]

, 2020
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations ...
Ellberg, Carolina,, Borg, Åke,, EMBRACE Collaborators, Olsson, Håkan,, GC-HBOC Study Collaborators, Feng, Helian,, Lund University., GEMO Study Collaborators   +7 more
core   +1 more source

Probabilistic fine-mapping of transcriptome-wide association studies [PDF]

, 2019
Transcriptome-wide association studies using predicted expression have identified thousands of genes whose locally regulated expression is associated with complex traits and diseases.
Kichaev, Gleb, Pasaniuc, Bogdan, Gleb Kichaev, Huwenbo Shi, Malika K. Freund, Gusev, Alexander, Bogdan Pasaniuc, Ruth Johnson, Shi, Huwenbo, Freund, Malika K, Johnson, Ruth, Nicholas Mancuso, Alexander Gusev, Mancuso, Nicholas   +13 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Fairfax County-Wide Black Citizens Association (BCA)

, 1970
By-laws of the Fairfax County-Wide Black Citizens ...
Fairfax County-Wide Black Citizens Association
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A genome-wide association search for type 2 diabetes genes in African Americans. [PDF]

, 2012
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.
Kumari, Meena, Seedorf, Udo, Sladek, Rob, Wu, Guanming, Rocheleau, Ghislain, McCarroll, Steve A, Bostrom, Meredith A, Pedersen, Oluf, Sanna, Serena, Marmot, Michael, McCarthy, Mark I, Amin, Najaf, van Dijk, Ko Willems, Divers, Jasmin, Hicks, Andrew A, Yarnell, John W G, Pearson, Daniel, Langefeld, Carl D, Dedoussis, George V, Elliott, Paul, Kao, Wen H L, Owen, Katharine R, Kaprio, Jaakko, Cavalcanti-Proença, Christine, Cooper, Matthew N, van Haeften, Timon W, Navarro, Pau, Strassburger, Klaus, Hammond, Naomi, Qi, Lu, McCulloch, Laura J, Uitterlinden, André G, Groves, Christopher J, Tönjes, Anke, Barroso, Inês, Palmer, Nicholette D, Kyvik, Kirsten Ohm, Waeber, Gérard, Boehm, Bernhard O, Loos, Ruth J F, Sijbrands, Eric, Bochud, Murielle, Boerwinkle, Eric, Bowden, Donald W, Lind, Lars, Le Bacquer, Olivier, Kong, Augustine, Mooser, Vincent, Timpson, Nicholas J, Pakyz, Ruth, Meisinger, Christa, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Wichmann, H-Erich, Ardlie, Kristin, Klopp, Norman, Goel, Anuj, Wright, Alan F, Franzosi, Maria Grazia, de Geus, Eco J C, Hallmans, Göran, Pramstaller, Peter Paul, Raychaudhuri, Soumya, Syvänen, Ann-Christine, Cauchi, Stephane, Salomaa, Veikko, Han, Xijing, Zethelius, Björn, Collins, Francis S, Blagieva, Roza, Hillman, David R, Ingelsson, Erik, Singleton, Andrew, Williams, Gordon H, Fischer-Rosinsky, Antje, Zhao, Jing Hua, Sethupathy, Praveen, Pattou, François, Lajunen, Taina, Serrano-Ríos, Manuel, Walker, Mark, Zillikens, M Carola, Borecki, Ingrid B, Rotimi, Charles N, Doney, Alex S F, Shields, Beverley, Melzer, David, Vitart, Veronique, Elliott, Katherine S, Uda, Manuela, McAteer, Jarred B, Scuteri, Angelo, Isomaa, Bo, Prokopenko, Inga, Rice, Kenneth, Bergmann, Sven, Hofmann, Oliver M, Lu, Lingyi, Dupuis, Josée, Pfeiffer, Andreas F H, Hunter, David J, Sparsø, Thomas, Mukherjee, Sutapa, Sladek, Robert, Uitterlinden, Andre, Martínez-Larrad, María Teresa, Morris, Andrew P, Crisponi, Laura, Chines, Peter S, Morris, Andrew D, Hitman, Graham A, Henneman, Peter, Silveira, Angela, Rotter, Jerome I, Visvikis-Siest, Sophie, Welch, Ryan P, Böttcher, Yvonne, Thorand, Barbara, Pedersen, Nancy L, Sale, Michele M, Lewis, Joshua P, Brunner, Eric, Forouhi, Nita G, Knight, Beatrice, Wilson, James F, Adeyemo, Adebowale, Li, Yun, Palmer, Lyle J, Grarup, Niels, McCarroll, Steven A, Shields, Beverley M, Gyllensten, Ulf, van Dam, Rob M, Chen, Yii-Der Ida, Potter, Simon C, Crawford, Gabe, Dehghan, Abbas, Ferreira, Teresa, Goodarzi, Mark O, Perola, Markus, Ruokonen, Aimo, Hercberg, Serge, Kesaniemi, Y Antero, Witteman, Jaqueline C M, Delplanque, Jerome, Shuldiner, Alan R, Rayner, Nigel W, Waterworth, Dawn M, Sampson, Michael J, Polasek, Ozren, Koskinen, Seppo, van Herpt, Thijs, Charpentier, Guillaume, Graessler, Jürgen, Posthuma, Danielle, Borch-Johnsen, Knut, Wild, Sarah H, Deloukas, Panos, Jackson, Anne U, Randall, Joshua, Grundy, Scott, Stumvoll, Michael, Karpe, Fredrik, Hofman, Albert, Li, Man, Oostra, Ben A, Schlessinger, David, Illig, Thomas, Meitinger, Thomas, Cooke, Jessica N, Coin, Lachlan J M, Franks, Paul W, Laakso, Markku, Kanoni, Stavroula, Day, Ian N M, Lathrop, G Mark, Heath, Simon C, Burtt, Noël P, Wheeler, Eleanor, Roh, Bong H, Ariyurek, Yavuz, Altshuler, David, Bornstein, Stefan R, Griffin, Simon, Spector, Timothy D, Mohlke, Karen L, Luan, Jian'an, Stringham, Heather M, Beilby, John P, Walters, G Bragi, Tichet, Jean, Doney, Alex, Swift, Amy J, Stein, Lincoln D, Jørgensen, Torben, Hveem, Kristian, Ebrahim, Shah, Midthjell, Kristian, Spranger, Joachim, Guiducci, Candace, Lieverse, Aloysius, Witteman, Jacqueline, Bumpstead, Suzannah, Ferrara, Assiamira, Kaakinen, Marika, Sigurdsson, Gunnar, Robertson, Neil R, Hu, Frank B, Cornelis, Marilyn, Campbell, Harry, Bouatia-Naji, Nabila, Kivimaki, Mika, Narisu, Narisu, Bonnefond, Amélie, Naitza, Silvia, Langenberg, Claudia, Voight, Benjamin F, Bennett, Amanda J, Hicks, Pamela J, Gwilliam, Rhian, Magnusson, Patrik K E, Ferrucci, Luigi, Psaty, Bruce M, Nilsson, Peter, Ng, Maggie C Y, Sijbrands, Eric J G, Ward, Kim L, Florez, Jose C, Wagner, Peter J, Talbert, Matthew E, Roden, Michael, Swift, Amy, Roccasecca, Rosa Maria, Pouta, Anneli, Lindgren, Cecilia M, Kao, W H Linda, Wareham, Nicholas J, Meneton, Pierre, Shrader, Peter, Wing, Maria R, Zeggini, Eleftheria, Green, Todd, Palmer, Colin N A, Rivadeneira, Fernando, Franklin, Christopher S, Grallert, Harald, Manning, Alisa K, Willemsen, Gonneke, Freedman, Barry I, Zabena, Carina, Daly, Mark J, Rudock, Megan E, Rathmann, Wolfgang, Clarke, Robert, Sun, Qi, Scott, Laura J, Benediktsson, Rafn, Peltonen, Leena, Mangino, Massimo, Scheet, Paul, Boehnke, Michael, Mitchell, Braxton D, Sandhu, Manjinder, Varma, Dhiraj, Boström, Kristina Bengtsson, Thorsteinsdottir, Unnur, Steinthorsdottir, Valgerdur, Pichler, Irene, Hassanali, Neelam, Silander, Kaisa, Shriner, Daniel, Rolandsson, Olov, Lecoeur, Cécile, Zhai, Guangju, Chines, Peter, Egan, Josephine M, Meigs, James B, Rayner, N William, Meyre, David, Johnson, Paul R V, Saxena, Richa, Frayling, Timothy M, Nathan, David M, Pattaro, Cristian, Marre, Michel, Boomsma, Dorret I, Vogelzangs, Nicole, Smith, Nicholas L, Peden, John F, Payne, Felicity, Ganser, Martha, Lyssenko, Valeriya, Bravenboer, Bert, Proença, Christine, Rudan, Igor, Stefansson, Kari, Hattersley, Andrew T, Smith, George Davey, An, S Sandy, Simpson, Laila, Abecasis, Goncalo R, Kovacs, Peter, Vollenweider, Peter, Kraft, Peter, Ben-Shlomo, Yoav, Huth, Cornelia, Frants, Rune, Soranzo, Nicole, Hayward, Caroline, Wijmenga, Cisca, Weedon, Michael N, Schwarz, Peter, Mägi, Reedik, van Vliet-Ostaptchouk, Jana V, Johnson, Toby, Lauritzen, Torsten, Zelenika, Diana, Lawlor, Debbie A, Neville, Matthew J, Syddall, Holly, Willer, Cristen J, Gieger, Christian, Siscovick, David S, Ziegler, Julie T, Watanabe, Richard M, Hester, Jessica M, Walley, Andrew, Hottenga, Jouke Jan, Penninx, Brenda W J H, Hui, Jennie, Herder, Christian, Kuusisto, Johanna, Bonnycastle, Lori L, Thorleifsson, Gudmar, McDonough, Caitrin W, An, Ping, Mahley, Robert, Barter, Philip, Hide, Winston A, Elliott, Amanda, Sharp, Stephen J, Watkins, Hugh, Pankow, James S, Buchanan, Thomas A, Valle, Timo T, Segrè, Ayellet V, O'Connell, Jeffrey, Couper, David J, Hung, Joe, Bergman, Richard N, Fedson, Annette C, Morken, Mario A, Balkau, Beverley, McPherson, Ruth, Cao, Antonio, Tanaka, Toshiko, Song, Kijoung, Glazer, Nicole L, Rybin, Denis, Elliott, Amanda L, Orrù, Marco, Hansen, Torben, Dina, Christian, Hingorani, Aroon D, Sovio, Ulla, Aulchenko, Yurii S, Jula, Antti, Perry, John R B, van Hoek, Mandy, Pramstaller, Peter P, Froguel, Philippe, Province, Michael A, Gloyn, Anna L, Platou, Carl, Cooper, Cyrus, Petersen, Ann-Kristin, Sayer, Avan Aihie, Paolisso, Giuseppe, van Duijn, Cornelia M, Hadjadj, Samy, Groop, Leif, Ripatti, Samuli, Galan, Pilar, Erdos, Michael R, Bumpstead, Suzannah J, Tuomilehto, Jaakko, Hamsten, Anders, Fox, Caroline S, Tuomi, Tiinamaija, Sandbaek, Annelli   +389 more
core   +3 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study

Human Genomics
Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal.
Eunyoung Choi, Jaeseung Song, Yubin Lee, Yeonbin Jeong, Wonhee Jang   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source