Results 51 to 60 of about 186,950 (249)

Germin and germin-like proteins: evolution, structure, and function [PDF]

, 2008
Germin and germin-like proteins (GLPs) are encoded by a family of genes found in all plants. They are part of the cupin superfamily of biochemically diverse proteins, a superfamily that has a conserved tertiary structure, though with limited similarity ...
Dunwell, Jim, Gibbings, J. George, Mahmood, Tariq, Saqlan Naqvi, S.M.   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Elucidating the susceptibility to breast cancer: an in-depth proteomic and transcriptomic investigation into novel potential plasma protein biomarkers

Frontiers in Molecular Biosciences
Objectives: This study aimed to identify plasma proteins that are associated with and causative of breast cancer through Proteome and Transcriptome-wide association studies combining Mendelian Randomization.Methods: Utilizing high-throughput datasets, we
Yang Wang, Kexin Yi, Baoyue Chen, Bailin Zhang, Gao Jidong, Gao Jidong   +5 more
doaj   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins

Frontiers in Neuroscience, 2020
Monozygotic twins are genetically identical but rarely phenotypically identical. Epigenetic and transcriptional variation could influence this phenotypic discordance.
Mette Soerensen, Mette Soerensen, Mette Soerensen, Dominika Marzena Hozakowska-Roszkowska, Dominika Marzena Hozakowska-Roszkowska, Marianne Nygaard, Marianne Nygaard, Martin J. Larsen, Martin J. Larsen, Veit Schwämmle, Kaare Christensen, Kaare Christensen, Kaare Christensen, Lene Christiansen, Lene Christiansen, Qihua Tan, Qihua Tan, Qihua Tan   +17 more
doaj   +1 more source

Using multi-tissue transcriptome-wide association study to identify candidate susceptibility genes for respiratory infectious diseases

Frontiers in Genetics, 2023
Objective: We explore the candidate susceptibility genes for influenza A virus (IAV), measles, rubella, and mumps and their underlying biological mechanisms.Methods: We downloaded the genome-wide association study summary data of four virus-specific ...
Xiaobo Zhu, Yixin Zou, Linna Jia, Xiangyu Ye, Yanzheng Zou, Junlan Tu, Juntong Li, Rongbin Yu, Sheng Yang, Peng Huang   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genetic insights into the dissolution of dioecy in diploid persimmon Diospyros oleifera Cheng

BMC Plant Biology, 2023
Background Dioecy, a sexual system of single-sexual (gynoecious/androecious) individuals, is rare in flowering plants. This rarity may be a result of the frequent transition from dioecy into systems with co-sexual individuals.
Peng Sun, Soichiro Nishiyama, Huawei Li, Yini Mai, Weijuan Han, Yujing Suo, Chengzhi Liang, Huilong Du, Songfeng Diao, Yiru Wang, Jiaying Yuan, Yue Zhang, Ryutaro Tao, Fangdong Li, Jianmin Fu   +14 more
doaj   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays. [PDF]

, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Bandillo, Nonoy B, Buckler, Edward S, Diepenbrock, Christine H, Gore, Michael A, Kremling, Karl AG   +4 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source