Results 31 to 40 of about 41,997,714 (232)

Transcriptome-wide association and prediction for carotenoids and tocochromanols in fresh sweet corn kernels

, 2021
Sweet corn is consistently one of the most highly consumed vegetables in the U.S., providing a valuable opportunity to increase nutrient intake through biofortification.
University of Georgia (17856095)
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From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source

supplemental data for manuscript Genome wide association studies and transcriptome changes during acclimation

, 2020
supplemental data for manuscript Genome wide association studies and transcriptome changes during ...
David Horvath
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Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. [Elektronisk resurs]

, 2020
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations ...
Ellberg, Carolina,, Borg, Åke,, EMBRACE Collaborators, Olsson, Håkan,, GC-HBOC Study Collaborators, Feng, Helian,, Lund University., GEMO Study Collaborators   +7 more
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Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

Genome-wide association study of receptive language ability of 12 year olds [PDF]

, 2013
Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...
Hanscombe, K.B., Meaburn, Emma L, Dale, Philip S, Plomin, Robert, Hayiou-Thomas, Marianna E, Jankowski, Janusz, Haworth, Claire M.A., Trzaskowski, M., Haworth, C., Haworth, Claire M. A., Hayiou-Thomas, Marianna E., Wellcome Trust Case Control Consortium (including Jankowski J), Harlaar, N., Haworth, Claire M A, Dale, Philip S., Dale, P., Harlaar, Nicole, Price, T.S, Price, Thomas S, Docherty, Sophia, Hayiou-Thomas, M.E., Davis, Oliver S. P., Plomin, R., Meaburn, Emma L., Price, Tom S., HASH(0x55a67fe4f3e8), Hanscombe, Ken B., ?, ?, Davis, O.S.P., Docherty, S.J., Price, Thomas S., Trzaskowski, Maciej, Davis, Oliver S P   +32 more
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Integrating multiple omics approaches to identify AIF1 as a protective factor in IgA nephropathy

Journal of Translational Autoimmunity
IgA nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide, and its diagnosis still relies on invasive kidney biopsy. To identify noninvasive biomarkers and therapeutic targets, we applied a multi-ancestry Mendelian randomization ...
Xingyu Liu, Yiyang Hu, Wenjia Zhang, Chaohong Nie, Fengxia Zhang, Yufeng Liu, Xiaoyan Su, Shuangxin Liu, Quhuan Li   +8 more
doaj   +1 more source

Integrating Genome-Wide Association Studies and Gene Expression Profiles With Chemical-Genes Interaction Networks to Identify Chemicals Associated With Colorectal Cancer

Frontiers in Genetics, 2020
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate in global cancer. Exploring the associations between chemicals and CRC has great significance in prophylaxis and therapy of tumor diseases.
Xinyue Tan, Hanmin Tang, Liuyun Gong, Lina Xie, Yutiantian Lei, Zhenzhen Luo, Chenchen He, Jinlu Ma, Suxia Han   +8 more
doaj   +1 more source

Genome-Wide Association Study of Major Depressive Disorder: New Results, Meta-Analysis, and Lessons Learned [PDF]

, 2010
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)).
D I Boomsma, Sullivan, P.F., Sullivan, P F, G Willemsen, D J Statham, Willemsen, G.; id_orcid, Gordon, SD, Penninx, BWJH, Smit, J H, Medland, S E, Maclean, A.W., S E Medland, Penninx, B. W. J. H., van den Oord, E J C G, Montgomery, G W, Pergadia, M L, Byrne, E.M., Heath, A.C., Martin, N.G., MacIntyre, Donald; id_orcid, Hickie, I.B., Statham, D.J., C M Middeldorp, E M Byrne, B W J H Penninx, Nyholt, D.R., J J Hottenga, J H Smit, A K Henders, Blackwood, D.H., Liu, J. Z., N G Martin, A W Maclean, Lewis, C.M., Montgomery, G. W., McGuffin, P, S D Gordon, McEvoy, B.P., MacIntyre, D J, McGhee, K A, P A F Madden, MacIntyre, D J; id_orcid, Pergadia, M. L., van den Oord, E.J., McEvoy, B P, Gordon, S.D., Martin, N. G., D H R Blackwood, P F Sullivan, De Geus, E. J. C., Montgomery, G.W., Hottenga, J.J., Hickie, I. B., McGhee, K.A., Medland, S. E., C M Lewis, J Z Liu, Gordon, S D, Smit, J. H., Boomsma, D. I., Hottenga, J. J., Smit, J.H., Middeldorp, C.M., Ripke, S., M L Pergadia, Hickie, I B, de Geus, E.J., Wray, NR, Van Den Oord, E. J. C. G., Wray, N. R., Blackwood, DHR, de Geus, E J C, Penninx, B.W., B P McEvoy, McGhee, K. A., Middeldorp, C. M., Byrne, E. M., McEvoy, B. P., Macgregor, S, E J C G van den Oord, Statham, D J, Heath, A C, Lewis, C. M., van den Oord, E.J.C.G., I B Hickie, Willemsen, G., Pergadia, M.L., Medland, S.E., Sullivan, P. F., Penninx, B.W.J.H., Heath, A. C., Maclean, AW, Nyholt, D. R., N R Wray, S Macgregor, MacIntyre, DJ, Boomsma, D.I., G W Montgomery, Lewis, C M, Henders, A K, Madden, P. A. F., Madden, P.A.F., Henders, A.K., Hottenga, J J, McGuffin, P., Boomsma, D I, Madden, P.A., de Geus, E.J.C.; id_orcid, Henders, A. K., Wray, N R, Madden, P A F, E J C de Geus, Pergadia, ML, D R Nyholt, Maclean, A W, Ripke, S, A C Heath, Ripke, Stephan, MacIntyre, D. J., Blackwood, D. H. R., Statham, D. J., Penninx, B W J H, Gordon, S. D., McGhee, KA, D J MacIntyre, Nyholt, D R, Wray, N.R., Middeldorp, C M, Liu, J Z, S Ripke, K A McGhee, P McGuffin, Nyholt, DR, Willemsen, G, Boomsma, D.I.; id_orcid, Lewis, C. M.; id_orcid, Martin, N G, Blackwood, D H R, Liu, J.Z., Byrne, E M, MacIntyre, D.J., MacGregor, S., MacLean, A. W.   +142 more
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Model checking via testing for direct effects in Mendelian Randomization and transcriptome-wide association studies

, 2021
This article proposes a new and general goodness-of-fit (GOF) test, called TEDE (TEsting Direct Effects), applicable to both correlated and independent SNPs/IVs as commonly used in transcriptome-wide association studies (TWAS) and Mendelian ...
Pan, Wei, Deng, Yangqing, Wei Pan, Yangqing Deng   +3 more
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