Results 11 to 20 of about 41,997,714 (232)

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

open access: yesCancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong   +5 more
doaj   +2 more sources

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci [PDF]

open access: yesBreast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen   +56 more
doaj   +7 more sources

Additional file 3 of Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis

open access: yes, 2023
Additional file 3: Table S1 Top genes selected by transcriptome-wide association study (TWAS ...
Menghao Teng (16939097)   +4 more
core   +1 more source

Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology [PDF]

open access: yes, 2022
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data.
Fairbanks-Mahnke, Ana   +65 more
core   +1 more source

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer [PDF]

open access: yes, 2018
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown.
Shi, Wei   +999 more
core   +6 more sources

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

open access: yesFrontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma   +10 more
doaj   +1 more source

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

open access: yesRice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei   +7 more
doaj   +1 more source

Assigning function to genome wide association study variants associated with complex gastrointestinal disease [PDF]

open access: yes, 2009
PhDThe genome‐wide association study era has identified numerous loci associated with many common polygenic diseases. The next challenge is to identify the functional consequences of these variants and elicit how they impact on disease risk.
Heap, Graham Alastair Richard
core   +2 more sources

Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease [PDF]

open access: yes, 2022
Genetic correlations and an increased incidence of psychiatric disorders in inflammatory-bowel disease have been reported, but shared molecular mechanisms are unknown. We performed cross-tissue and multiple-gene conditioned transcriptome-wide association
Borisov, Oleg V.   +67 more
core   +2 more sources

Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study

open access: yesFrontiers in Genetics, 2022
Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu   +7 more
doaj   +1 more source

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