Results 11 to 20 of about 186,950 (249)

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
doaj   +1 more source

Simultaneous profiling of transcriptome and DNA methylome from a single cell. [PDF]

, 2016
BackgroundSingle-cell transcriptome and single-cell methylome technologies have become powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide scale. A major challenge has been to understand the direct correlation of DNA
An, Qin, Du, Guizhen, Fan, Guoping, Hu, Ganlu, Hu, Youjin, Huang, Kevin, Wang, Cun-Yu, Xue, Jinfeng, Xue, Zhigang, Zhu, Xianmin   +9 more
core   +3 more sources

2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]

, 2018
The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin, Xu, Shizhong, Zhang, Wenchao, Zhao, Patrick X   +3 more
core   +2 more sources

Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study

Frontiers in Genetics, 2022
Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu, Yu-Qing Hou, Xiang-Yu Ye, Yi-Xin Zou, Xue-Shan Xia, Sheng Yang, Peng Huang, Rong-Bin Yu   +7 more
doaj   +1 more source

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas, Jhamb, Deepali, Rajpal, Deepak K, Shu, Le, Yang, Xia, Zhao, Yuqi   +5 more
core   +3 more sources

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Crawford, Gregory E, Finucane, Hilary K, Geschwind, Daniel H, Gusev, Alexander, Katsanis, Nicholas, Kousi, Maria, Mancuso, Nicholas, McCarroll, Steven, Neale, Benjamin M, O'Donovan, Michael C, Ophoff, Roel A, Pasaniuc, Bogdan, Price, Alkes L, Reshef, Yakir, Safi, Alexias, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Song, Lingyun, Sullivan, Patrick F, Won, Hyejung   +18 more
core   +2 more sources

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source