Results 1 to 10 of about 345,542 (371)

Transcriptome-wide association study reveals novel susceptibility genes for coronary atherosclerosis. [PDF]

Front Cardiovasc Med, 2023
Background Genetic risk factors substantially contributed to the development of coronary atherosclerosis. Genome-wide association study (GWAS) has identified many risk loci for coronary atherosclerosis, but the translation of these loci into therapeutic ...
Zhao Q, Liu R, Chen H, Yang X, Dong J, Bai M, Lu Y, Leng Y.   +7 more
europepmc   +5 more sources

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

Nature Genetics, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Crawford, Gregory E, Finucane, Hilary K, Geschwind, Daniel H, Gusev, Alexander, Katsanis, Nicholas, Kousi, Maria, Mancuso, Nicholas, McCarroll, Steven, Neale, Benjamin M, O'Donovan, Michael C, Ophoff, Roel A, Pasaniuc, Bogdan, Price, Alkes L, Reshef, Yakir, Safi, Alexias, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Song, Lingyun, Sullivan, Patrick F, Won, Hyejung   +18 more
core   +3 more sources

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

Genome Medicine, 2021
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.
Yanfa Sun, Jingjing Zhu, Dan Zhou, Saranya Canchi, Chong Wu, Nancy J. Cox, Robert A. Rissman, Eric R. Gamazon, Lang Wu   +8 more
doaj   +2 more sources

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine. [PDF]

J Headache Pain
Background Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), the underlying causative genes and ...
Gui J, Yang X, Tan C, Wang L, Meng L, Han Z, Liu J, Jiang L.   +7 more
europepmc   +2 more sources

Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs [PDF]

Advanced Science
Many cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...
Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li   +14 more
doaj   +2 more sources

Gaining new insights into the etiology of ulcerative colitis through a cross-tissue transcriptome-wide association study. [PDF]

Front Genet
Background Genome-wide association studies (GWASs) have identified 38 loci associated with ulcerative colitis (UC) susceptibility, but the risk genes and their biological mechanisms remained to be comprehensively elucidated. Methods Multi-marker analysis
Ren S, Sun C, Zhai W, Wei W, Liu J.
europepmc   +2 more sources

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning. [PDF]

Nat Commun
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expression imputation
Parrish RL, Buchman AS, Tasaki S, Wang Y, Avey D, Xu J, De Jager PL, Bennett DA, Epstein MP, Yang J.   +9 more
europepmc   +2 more sources

webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study. [PDF]

Nucleic Acids Res
Transcriptome-wide association study (TWAS) has successfully identified numerous complex disease susceptibility genes in the post-genome-wide association study (GWAS) era.
Cao C, Shao M, Wang J, Li Z, Chen H, You T, Li MJ, Ding Y, Zou Q.   +8 more
europepmc   +2 more sources

Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract. [PDF]

Front Ophthalmol (Lausanne)
Introduction Cataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%.
Choquet H, Duot M, Herrera VA, Shrestha SK, Meyers TJ, Hoffmann TJ, Sangani PK, Lachke SA.   +7 more
europepmc   +2 more sources

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study. [PDF]

Nat Commun
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.
Chen H, Wang Z, Gong L, Wang Q, Chen W, Wang J, Ma X, Ding R, Li X, Zou X, Plass M, Lian C, Ni T, Wei GH, Li W, Deng L, Li L.   +16 more
europepmc   +2 more sources