Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study [PDF]
Human GenomicsBackground Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal.
Eunyoung Choi +4 more
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Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs [PDF]
Advanced ScienceMany cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 ...
Wenyan Chen +14 more
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Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes [PDF]
HGG AdvancesSummary: Abdominal hernias are caused by the protrusion of an organ or tissue through a weakened abdominal wall. Genome-wide association studies (GWASs) have identified 81 genetic susceptibility loci for different hernia subtypes, with 26 loci associated
Dima L. Chaar +10 more
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A Transcriptome‐Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk [PDF]
Cancer MedicineBackground Genome‐wide association studies (GWAS) have identified over 80 susceptibility loci for lung cancer risk. However, the genes underlying these associations remain largely unknown. Methods We conducted a large transcriptome‐wide association study
Tianying Zhao +13 more
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Cells, 2022 Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu +4 more
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Dissecting the genetic heterogeneity of gastric cancerResearch in context
EBioMedicine, 2023 Summary: Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes.
Timo Hess +133 more
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Journal of Translational Medicine, 2022 Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive.
Bang-Sheng Wu +7 more
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Transcriptome-wide association study identified candidate genes associated with gut microbiota
Gut Pathogens, 2021 Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan +12 more
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Identifying causal genes for migraine by integrating the proteome and transcriptome
The Journal of Headache and Pain, 2023 Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li +19 more
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Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues
Frontiers in Immunology, 2021 Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Xingang Li +19 more
doaj +1 more source