Results 41 to 50 of about 345,542 (371)

Novel insight into the aetiology of rheumatoid arthritis gained by a cross-tissue transcriptome-wide association study

RMD Open, 2022
Background Although genome-wide association studies (GWASs) have identified more than 100 loci associated with rheumatoid arthritis (RA) susceptibility, the causal genes and biological mechanisms remain largely unknown.
J. Ni, Peng Wang, K. Yin, Xiao-Ke Yang, H. Cen, Cong Sui, Guo-Cui Wu, Haifeng Pan   +7 more
semanticscholar   +1 more source

Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation [PDF]

, 2015
peer-reviewedData Availability: The raw sequencing reads (FASTQ files) and sequence read counts mapped to UCSC hg19 for each of the 74 transcriptomes sequenced in this study have been deposited at Gene Expression Omnibus (GEO) accession GSE69549.This ...
Castro, Patricia Dominguez, Coleman, Ciara, Cormican, Paul, Mahmud, Nasir, McManus, Ross, Molloy, Ben, Quinn, Emma M, Trimble, Valerie   +7 more
core   +6 more sources

Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues

Frontiers in Immunology, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Xingang Li, Xingang Li, Hao Wang, Hao Wang, Yahong Zhu, Weijie Cao, Weijie Cao, Manshu Song, Manshu Song, Youxin Wang, Haifeng Hou, Minglin Lang, Xiuhua Guo, Xuerui Tan, Jingdong J. Han, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang   +19 more
doaj   +1 more source

Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology

Nature Communications, 2022
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data.
S. Sajuthi, J. Everman, Nathan D. Jackson, B. Saef, C. Rios, Camille M. Moore, Angel C. Y. Mak, C. Eng, A. Fairbanks-Mahnke, S. Salazar, J. Elhawary, S. Huntsman, V. Medina, D. Nickerson, S. Germer, M. Zody, G. Abecasis, H. Kang, K. Rice, Rajesh Kumar, N. Zaitlen, Sam S. Oh, J. Rodriguez-Santana, E. Burchard, M. Seibold   +24 more
semanticscholar   +1 more source

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci

Breast Cancer Research, 2022
Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen, Shaoqi Fan, Jennifer Stone, Deborah J. Thompson, Julie Douglas, Shuai Li, Christopher Scott, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Christopher Li, Ulrike Peters, John L. Hopper, Melissa C. Southey, Tu Nguyen-Dumont, Tuong L. Nguyen, Peter A. Fasching, Annika Behrens, Gemma Cadby, Rachel A. Murphy, Kristan Aronson, Anthony Howell, Susan Astley, Fergus Couch, Janet Olson, Roger L. Milne, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Stacey Winham, Esther M. John, Allison Kurian, Heather Eliassen, Irene Andrulis, D. Gareth Evans, William G. Newman, Per Hall, Kamila Czene, Anthony Swerdlow, Michael Jones, Marina Pollan, Pablo Fernandez-Navarro, Daniel S. McConnell, Vessela N. Kristensen, NBCS Investigators, Joseph H. Rothstein, Pei Wang, Laurel A. Habel, Weiva Sieh, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Gretchen L. Gierach, Rulla M. Tamimi, Celine M. Vachon, Sara Lindström   +56 more
doaj   +1 more source

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

Translational Psychiatry, 2021
Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li, X. Su, Jie-wei Liu, Huijuan Li, Ming Li, Wenqiang Li, Xiongjian Luo   +6 more
semanticscholar   +1 more source

Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo. [PDF]

Int J Mol Sci
Wei K, Lu Y, Ma X, Duan A, Lu X, Abdel-Shafy H, Deng T.   +6 more
europepmc   +3 more sources

Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

eLife, 2022
Genome-wide association studies (GWASs) for bone mineral density (BMD) in humans have identified over 1100 associations to date. However, identifying causal genes implicated by such studies has been challenging.
B. Al-Barghouthi, Will T. Rosenow, Kangping Du, J. Heo, R. Maynard, L. Mesner, G. Calabrese, Aaron Nakasone, Bhavya Senwar, L. Gerstenfeld, James Larner, Virginia Ferguson, C. Ackert-Bicknell, E. Morgan, D. Brautigan, C. Farber   +15 more
semanticscholar   +1 more source

Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice

Rice, 2023
Root system architecture plays a crucial role in nutrient and water absorption during rice production. Genetic improvement of the rice root system requires elucidating its genetic control.
Shujun Wei, Ryokei Tanaka, Taiji Kawakatsu, Shota Teramoto, Nobuhiro Tanaka, Matthew Shenton, Yusaku Uga, Shiori Yabe   +7 more
doaj   +1 more source