Results 81 to 90 of about 181,971 (294)

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. [PDF]

, 2016
Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across multiple tumour types. However, to date, cancer profiling has largely focused on protein-coding genes, which
Backofen, Rolf, Cao, Xuhong, Chinnaiyan, Arul M, Collins, Colin, Feng, Felix Y, Gawronski, Alexander, Han, Sumin, Hayes, Daniel F, Hosono, Yasuyuki, Iyer, Matthew K, Kregel, Steven, Ma, Teng, Malik, Rohit, Niknafs, Yashar S, Pierce, Lori J, Pitchiaya, Sethuramasundaram, Poliakov, Anton, Prensner, John R, Rae, James M, Sahinalp, Cenk S, Siebenaler, Ronald F, Singhal, Udit, Speers, Corey, Uhl, Michael, Wilder-Romans, Kari, Xiao, Lanbo, Zhang, Chao, Zhao, Shuang G   +27 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]

, 2006
The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier, Birkholtz, Lyn-Marie, Breton, Vincent, Grando, Delphine, Hofmann-Apitius, Martin, Jacq, Nicolas, Joubert, Fourie, Kasam, Vinod, Louw, Abraham I, Maréchal, Eric, Ortet, Philippe, Roy, Sylvaine, Saïdani, Nadia, Wells, Gordon, Zimmermann, Marc   +14 more
core   +4 more sources

Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits [PDF]

, 2021
Bryce Rowland, Sanan Venkatesh, Manuel Tardáguila, Jia Wen, Jonathan D. Rosen, Amanda L. Tapia, Quan Sun, Mariaelisa Graff, Dragana Vuckovic, Guillaume Lettre, Vijay G. Sankaran, Alexander P. Reiner, Nicole Soranzo, Jennifer E. Huffman, Georgios Voloudakis, Panos Roussos, Laura M. Raffield, Yun Li   +17 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics. [PDF]

, 2020
Reactive Nitrogen Species (RNS) are a group of bactericidal molecules produced by macrophages in response to pathogens in a process called oxidative burst.
Cánovas, Angela, Emam, Mehdi, Fonseca, Pablo AS, Islas-Trejo, Alma D, Mallard, Bonnie, Medrano, Juan F   +5 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Transcriptome-wide association study identifies novel genes associated with child body mineral density and lean body mass [PDF]

, 2022
Jiawen Xu, Jun Ma, Yi Zeng, Haibo Si, Yuangang Wu, Shaoyun Zhang, Bin Shen   +6 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Multi-ethnic transcriptome-wide association study of prostate cancer.

PLoS ONE, 2020
The genetic risk for prostate cancer has been governed by a few rare variants with high penetrance and over 150 commonly occurring variants with lower impact on risk; however, most of these variants have been identified in studies containing exclusively ...
Peter N Fiorica, Ryan Schubert, John D Morris, Mohammed Abdul Sami, Heather E Wheeler   +4 more
doaj   +1 more source