Results 231 to 240 of about 37,961 (284)

Receptor–mediated transcytosis of macromolecules across the blood–brain barrier

Expert Opinion on Drug Delivery, 2023
Introduction The blood–brain barrier (BBB) restricts brain access of virtually all macromolecules. Receptor-mediated transcytosis (RMT) is one strategy toward their brain delivery.
Habib Baghirov
semanticscholar   +1 more source

Role of Micelle Size in Cell Transcytosis-Based Tumor Extravasation, Infiltration, and Treatment Efficacy.

Nano letters (Print), 2023
Transcytosis-based active transport of cancer nanomedicine has shown great promise for enhancing its tumor extravasation and infiltration and antitumor activity, but how the key nanoproperties of nanomedicine, particularly particle size, influence the ...
Wufa Fan, Jiajia Xiang, Qiuyu Wei, Yisi Tang, Ying Piao, Shiqun Shao, Zhuxian Zhou, Jianbin Tang, Zi-Chen Li, Youqing Shen   +9 more
semanticscholar   +1 more source

Lung Endothelial Transcytosis

Comprehensive Physiology, 2020
AbstractTranscytosis of macromolecules through lung endothelial cells is the primary route of transport from the vascular compartment into the interstitial space. Endothelial transcytosis is mostly a caveolae‐dependent process that combines receptor‐mediated endocytosis, vesicle trafficking via actin‐cytoskeletal remodeling, and SNARE protein directed ...
Joshua H, Jones, Richard D, Minshall
openaire   +2 more sources

Enhanced Intracellular Transcytosis of Nanoparticles by Degrading Extracellular Matrix for Deep Tissue Radiotherapy of Pancreatic Adenocarcinoma

Nano Letters, 2022
Intracellular transcytosis can enhance the penetration of nanomedicines to deep avascular tumor tissues, but strategies that can improve transcytosis are limited.
Qin Wang, Hang Liu, Yu-Cai Wang
exaly   +2 more sources

Transcytosis-Inducing Multifunctional Albumin Nanomedicines with Deep Penetration Ability for Image-Guided Solid Tumor Treatment.

Small, 2023
Transcytosis is an active transcellular transportation pathway that has garnered interest for overcoming the limited deep penetration of nanomedicines in solid tumors.
Hyori Lee, Byullee Park, Jihye Lee, Yeoul Kang, Moongyu Han, Junseok Lee, Chulhong Kim, W. Kim   +7 more
semanticscholar   +1 more source

Transcytosis: Crossing Cellular Barriers

Physiological Reviews, 2003
Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev 83: 871–932, 2003; 10.1152/physrev.00001.2003.—Transcytosis, the vesicular transport of macromolecules from one side of a cell to the other, is a strategy used by multicellular organisms to selectively move material between two environments without altering the ...
Pamela L, Tuma, Ann L, Hubbard
exaly   +3 more sources

Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.

Atherosclerosis, 2023
BACKGROUND AND AIMS Inflammatory molecules play important roles in atherosclerosis. We aimed to illustrate the roles of serum amyloid A (SAA), and interleukin (IL)-1β in low density lipoproteins (LDL) transcytosis and atherosclerosis.
Xiong Jia, Zongtao Liu, Yixuan Wang, Geng Li, X. Bai   +4 more
semanticscholar   +1 more source

Enzyme-Triggered Transcytosis of Dendrimer–Drug Conjugate for Deep Penetration into Pancreatic Tumors

ACS Nano, 2020
The dense fibrotic stroma in pancreatic ductal adenocarcinoma (PDA) resists drug diffusion into tumor and leads to unsatisfied prognosis. To address this problem, we demonstrate a dendrimer-camptothecin (CPT) conjugate that actively penetrates deep into ...
Guowei Wang, Zhuxian Zhou, Yulian Wu
exaly   +2 more sources

Transcytosis in Drug Absorption and Distribution

2021
The term transcytosis designates the vesicular transcellular transport of molecules from one side of a polarized epithelial or endothelial cell to the other. It is a key process for the absorption and/or distribution of large molecules, e.g., macromolecules, or, in some cases, more complex entities, e.g., nanoscale particles/constructs.Epithelial cell ...
Talevi, Alan, Bellera, Carolina Leticia
openaire   +2 more sources

Epithelial Transcytosis of Immunoglobulins

Journal of Mammary Gland Biology and Neoplasia, 1998
Transcytosis plays a central role in the immunological functions of epithelia, including the sampling of antigens that enter the body via the digestive, respiratory and urogenital tracts and their presentation to underlying lymphoid tissues, the secretion of specific immunoglobulins required for the immune protection of mucosal surfaces and the ...
W, Hunziker, J P, Kraehenbuhl
openaire   +2 more sources