Results 221 to 230 of about 37,961 (284)

Evaluating the effect of minimal TIMP variants on protecting and transport across the rat brain microvascular cells (RBMEC). [PDF]

Sci Rep
Taheri E, Raeeszadeh-Sarmazdeh M.
europepmc   +1 more source

Apolipoprotein E receptor 2 in endothelium promote glucose tolerance by mediating insulin delivery to skeletal muscle. [PDF]

Mol Metab
Sacharidou A, Chambliss KL, Peng J, Tanigaki K, Islam MN, Sirsi S, Lemoff A, Hoyt K, Mineo C, Shaul PW.   +9 more
europepmc   +1 more source

Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies. [PDF]

ADMET DMPK
Vargas R, Martinez-Martinez N, Lizano-Barrantes C, Pacheco-Molina JA, García-Montoya E, Pérez-Lozano P, Suñé-Negre JM, Suñé C, Suñé-Pou M.   +8 more
europepmc   +1 more source

Role of Caveolae and Caveolin in Vascular Physiology and Pathology. [PDF]

J Am Heart Assoc
Zhang C, Hu W, Zhang J, Wang Z, Lu H.
europepmc   +1 more source

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Transcytosis-enabled active extravasation of tumor nanomedicine

Advanced Drug Delivery Reviews, 2022
Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors. Traditional nanomedicines have been designed to extravasate into tumor interstitium through the interendothelial gaps previously assumed rich in tumor blood ...
Jiajia Xiang, Shiqun, Zhuxian Zhou
exaly   +4 more sources

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

Biomaterials, 2021
The modification of targeting ligands on nanoparticles (NPs) is anticipated to enhance the delivery of therapeutics to diseased tissues. However, once exposed to the blood stream, NPs can immediately adsorb proteins to form the "protein corona," which ...
Wei Xiao, Yazhen Wang, Huilin Zhang
exaly   +2 more sources

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

Neuron, 2017
Baptiste Lacoste, Ayal Ben-zvi, David D Ginty   +2 more
exaly   +2 more sources

Modulating Intracellular Dynamics for Optimized Intracellular Release and Transcytosis Equilibrium

Advanced Materials
Active transcytosis‐mediated nanomedicine transport presents considerable potential in overcoming diverse delivery barriers, thereby facilitating tumor accumulation and penetration.
Shiqun, Zhuxian Zhou, You-Qing Shen
exaly   +2 more sources

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

Nature, 2019
Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke1, is initiated by passage of low-density lipoprotein (LDL) cholesterol into the artery wall and its engulfment by macrophages, which leads
Peter Michaely, Anza Darehshouri, Lin Xu
exaly   +2 more sources