Results 251 to 260 of about 37,961 (284)

Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease

Advanced Functional Materials, 2020
The effective treatment of Alzheimer's disease (AD) is hindered due to the hard blood–brain barrier (BBB) penetration and non‐selective distribution of drugs in the brain.
Lulu Cai, Chuanyao Yang, Wenfeng Jia, Yuwei Liu, Rou Xie, Ting Lei, Zhihang Yang, Xueqin He, Rongsheng Tong, Huile Gao   +9 more
semanticscholar   +1 more source

LDL transcytosis by protein membrane diffusion

The International Journal of Biochemistry & Cell Biology, 2004
Endothelial cell (EC) cultures of different, selected vascular beds and/or organs were screened for receptor-mediated transport of proteins with a semipermeable filter assay. In SVEC4-10 cells, a mouse lymphoid endothelial cell line, orosomucoid, albumin, insulin and LDL were transcytosed from the apical (luminal) to basal (abluminal) side by a ...
Elena S, Kuzmenko, Siamak, Djafarzadeh, Z Petek, Cakar, Klaus, Fiedler   +3 more
openaire   +2 more sources

Transcytosis of Galectin-3 in Mouse Intestine

2022
The GlycoLipid-Lectin (GL-Lect) hypothesis provides a conceptual framework to explain how endocytic pits are built in processes of clathrin-independent endocytosis. According to this hypothesis, oligomeric cellular or pathogenic lectins interact with glycosylated plasma membrane lipids in a way such as to drive the formation of tubular endocytic pits ...
Alena, Ivashenka, Christian, Wunder, Valerie, Chambon, Estelle, Dransart, Ludger, Johannes, Massiullah, Shafaq-Zadah   +5 more
openaire   +2 more sources

Transcytosis in cultured proximal tubular cells

The Journal of Membrane Biology, 1986
Studies were designed to examine fluid-phase pinocytosis in proximal tubular cells. Canine proximal tubules were obtained from the band IV of Percoll gradient centrifugation of the dispersed renal cortex, and were seeded on collagen-coated polycarbonate membranes. Integrity of monolayers was confirmed by electrophysiologic measurements, and by scanning
M S, Goligorsky, K A, Hruska
openaire   +2 more sources

Optimizing transferrin-mediated transcytosis

Science-Business eXchange, 2013
Caltech researchers have shown how modulating the transferrin content on gold nanoparticles can optimize their delivery into the brain via the transferrin receptor. The group now needs to determine whether its strategy will translate to drug-nanoparticle conjugates amenable for use in the CNS.
openaire   +1 more source

Transcytosis of Nanomedicine for Tumor Penetration

Nano Letters, 2019
The diffusion of nanomedicines used to treat tumors is severely hindered by the microenvironment, which is a challenge that has emerged as a bottleneck for the effective outcome of nanotherapies. Classical strategies for enhancing tumor penetration rely on passive movement in the extracellular matrix (ECM).
Yan Liu, Yingying Huo, Lin Yao, Yawen Xu, Fanqiang Meng, Haifeng Li, Kang Sun, Guangdong Zhou, Daniel S. Kohane, Ke Tao   +9 more
openaire   +2 more sources

Rab11-FIP2 regulates differentiable steps in transcytosis

American Journal of Physiology-Cell Physiology, 2007
Transcytosis through the apical recycling system of polarized cells is regulated by Rab11a and a series of Rab11a-interacting proteins. We have identified a point mutant in Rab11 family interacting protein 2 (Rab11-FIP2) that alters the function of Rab11a-containing trafficking systems.
Nicole A, Ducharme, Janice A, Williams, Asli, Oztan, Gerard, Apodaca, Lynne A, Lapierre, James R, Goldenring   +5 more
openaire   +2 more sources

Wnt Signaling Regulates MFSD2A-dependent Drug Delivery through Endothelial Transcytosis in Glioma.

Neuro-Oncology, 2023
Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, L. Uhrbom, A. Dimberg, Liang Wang, Lei Zhang   +18 more
semanticscholar   +1 more source

Transcytosis shuts the door for an unwanted guest

Trends in Plant Science, 2013
Penetration resistance is a well-described plant defense process, in which SOLUBLE N-ETHYLMALEIMIDE-SENSITIVE-FACTOR ATTACHMENT RECEPTOR (SNARE) proteins have essential roles in membrane fusion processes. Strong focal accumulation of these proteins at the site of attack by powdery mildew fungi has been considered important for their function.
Nielsen, Mads Eggert, Thordal-Christensen, H.   +1 more
openaire   +3 more sources

Analysis of Transcytosis of CCN2 by Chondrocytes

2016
Transcytosis is a mechanism for the transcellular transport of biomolecules. Analysis of transcytosis is frequently performed in cells with distinct polarity, such as brain endothelial cells. However, in cells without evident polarity, analysis of transcytosis has not been performed. Here, we describe a method for analyzing transcytosis of a CCN family
Kazumi, Kawata, Satoshi, Kubota, Masaharu, Takigawa   +2 more
openaire   +2 more sources