Results 31 to 40 of about 5,064 (210)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Batch and flow synthesis of nucleosides by enzymatic transglycosylation [PDF]
, 2017 Enzymatic methods for the preparation of high-value products have clearly shown their potential in many areas, including nucleic acid chemistry. Enzymes of nucleic acid metabolism such as nucleoside phosphorylases (NPs, EC 2.4.2) can be conveniently used
Rabuffetti M. +6 more
core +3 more sources
Angewandte Chemie, EarlyView.Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui +9 more
wiley +2 more sources
AMB Express, 2021 The glycosidases within GH5-23 cleave the glycosidic bond of β-glucosylated or rutinosylated flavonoids. Moreover, by virtue of their transglycosylation activity, glycoconjugates with glucosyl and rutinosyl moieties are accessible.
Michael Kotik +3 more
doaj +1 more source
Introducing transglycosylation activity in a liquefying α‐amylase [PDF]
FEBS Letters, 1999 By mutating Ala‐289 by Phe or Tyr in the Bacillus stearothermophilus α‐amylase, we induced this enzyme to perform alcoholytic reactions, a function not present in the wild‐type enzyme. This residue was selected from homology analysis with neopullulanase, where the residue has been implicated in the control of transglycosylation [Kuriki et al. (1996) J.
Saab-Rincón, Gloria +4 more
openaire +2 more sources
Molecules, 2023 The enzymatic transglycosylation of steviol glycosides can improve the edulcorant quality of steviol glycosides. Cyclodextrin glucanotransferase (CGTase) is one of the most popular glucanotransferases applied in this reaction.
Ruiqin Zhang +6 more
doaj +1 more source
Transglycosylation to Ginseng Saponins by Cyclomaltodextrin Glucanotransferases
Bioscience, Biotechnology, and Biochemistry, 2001 Ten new alpha-glucosylginsenosides were found to be synthesized from dextrin and four ginsenosides, -Rb1, -Rc, -Re, and -Rg1, by the successive actions of B. stearothermophilus cyclomaltodextrin glucanotransferase and Rhizopus glucoamylase. Seven of them were isolated in the pure state by extraction with n-butanol saturated with water, silica gel ...
KIM, Young-Hoi +4 more
openaire +2 more sources
α-Glucosidase and β-glucosidase from psychrotrophic strain arthrobacter sp. C2-2
Czech Journal of Food Sciences, 2005 In this work six psychophilic and psychrotrophic bacterial strains were screened for the presence of different glycosidase activities (α-galactosidase, α-glucosidase, β-glucosidase, α-mannosidase and β-glucuronidase).
Eva Benešová +2 more
doaj +1 more source
Molecules, 2019 Isomaltose–oligosaccharides (IMOs), as food ingredients with prebiotic functionality, can be prepared via enzymatic synthesis using α-glucosidase. In the present study, the α-glucosidase (GSJ) from Geobacillus sp.
Fan Zhang +6 more
doaj +1 more source
Enzymatic conversion of β-mannans: Analysing, evaluating and modifying transglycosylation properties of glycoside hydrolases [PDF]
, 2022 Retaining glycoside hydrolases are enzymes that catalyse the breakdown down of glycans through hydrolysis. Due to the double-replacement mechanism of the retaining glycoside hydrolases (GHs), which form an intermediate with part of the glycan covalently ...
Wiemann, Mathias
core