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Transient Receptor Potential Channels and Mechanosensation
Annual Review of Neuroscience, 2013Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with ...
Niels, Eijkelkamp +2 more
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Transient Receptor Potentials (TRPs) and Anaphylaxis
Current Allergy and Asthma Reports, 2012The transient receptor potential (TRP) superfamily consists of 28 members in mammals (27 in human) that act as polymodal sensors and ion channels. They regulate cellular calcium influx, generate depolarization thereby triggering voltage dependent cellular processes, and in turn they are critical in inducing the metabolic activities of cells.
Smith, Peter K, Nilius, Bernd
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Effects of chlorpyrifos on transient receptor potential channels
Toxicology Letters, 2022The well-known toxicity of chlorpyrifos (CPF) occurs via inhibition of cholinesterase (ChE), but in recent years the detrimental effects of low-dose CPF exposure have been attributed to an unknown non-cholinergic mechanism of action. We previously showed that CPF can alter gene expression of transient receptor potential canonical (TRPC) channels in ...
Wen, Li, Marion, Ehrich
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Transient receptor potential channels in essential hypertension
Journal of Hypertension, 2006The role of nonselective cation channels of the transient receptor potential channel (TRPC) family in essential hypertension has not yet been investigated.We studied TRPCs in 51 patients with essential hypertension and 51 age-matched and sex-matched normotensive control subjects.
Liu, Daoyan +10 more
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Canonical Transient Receptor Potential 5
2007Canonical transient receptor potential 5 TRPC5 (also TrpC5, trp-5 or trp5) is one of the seven mammalian TRPC proteins. Its known functional property is that of a mixed cationic plasma membrane channel with calcium permeability. It is active alone or as a heteromultimeric assembly with TRPC1; TRPC4 and TRPC3 may also be involved. Multiple activators of
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Transient Receptor Potential Vanilloid 1 and Xenobiotics
CNS & Neurological Disorders - Drug Targets, 2008Over the last couple of years, transient receptor potential vanilloid 1(TRPV1) channels have been a hot topic in ion channel research. Since this research field is still rather new, there is not much known about the working mechanism of TRPV1 and its ligands.
E, Cuypers +4 more
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An overview on transient receptor potential channels superfamily
Behavioural Pharmacology, 2019The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory ...
Merab G, Tsagareli, Ivliane, Nozadze
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Transient receptor potential channels as drug targets
Expert Opinion on Therapeutic Targets, 2007The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney.
Dayne Y, Okuhara +2 more
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Transient receptor potential channels and occupational exposure
Current Opinion in Allergy & Clinical Immunology, 2014The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract ...
Geppetti P, Patacchini R, Nassini R.
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Transient receptor potential channels in bladder function
Acta Physiologica, 2012AbstractThe transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons.
Avelino, A. +6 more
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