Results 171 to 180 of about 28,002 (191)

Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine

Gastroenterology, 2011
Transient receptor potential ankyrin (TRPA) 1, an excitatory ion channel expressed by sensory neurons, mediates somatic and visceral pain in response to direct activation or noxious mechanical stimulation. Although the intestine is routinely exposed to irritant alimentary compounds and inflammatory mediators that activate TRPA1, there is no direct ...
Daniel P, Poole, Juan Carlos, Pelayo, Fiore, Cattaruzza, Yien-Ming, Kuo, Gregory, Gai, Jonathon V, Chiu, Romke, Bron, John B, Furness, Eileen F, Grady, Nigel W, Bunnett   +9 more
openaire   +2 more sources

Tramadol and Its Metabolite M1 Selectively Suppress Transient Receptor Potential Ankyrin 1 Activity, but Not Transient Receptor Potential Vanilloid 1 Activity

Anesthesia & Analgesia, 2015
The transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1), which are expressed in sensory neurons, are polymodal nonselective cation channels that sense noxious stimuli. Recent reports showed that these channels play important roles in inflammatory, neuropathic, or cancer pain, suggesting that they may ...
Kanako, Miyano, Kouichiro, Minami, Toru, Yokoyama, Katsuya, Ohbuchi, Takuhiro, Yamaguchi, Satoshi, Murakami, Seiji, Shiraishi, Masahiro, Yamamoto, Motohiro, Matoba, Yasuhito, Uezono   +9 more
openaire   +2 more sources

STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception

Pain
Abstract STIM1 is a calcium sensor that can sense calcium level changes in the endoplasmic reticulum (ER) and respond to extracellular stimuli. We have reported that STIM1 is expressed in nociceptors. However, its functional significance remains unclear.
Yixiao Mei, Hareram Birla, Bo Hyun Lee, Zhixiao Li, Vipin Rai, Isis Zhang, Xiaodong Huo, Anni Yi, Qiao Zhang, Daling Li, Yu Zhong, Fengying Wang, Bushra Yasin, Carol Apai, Tibor Rohacs, Yuan-Xiang Tao, Alex Bekker, Huijuan Hu   +17 more
openaire   +2 more sources

Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1

Neuroscience Letters, 2011
Noxious cold reduces pruritus and transient receptor potential ankyrin subfamily member 1 (TRPA1), a non-selective cation channel, is known as a noxious cold-activated ion channel. Recent findings implicated the involvement of TRPA1 in pain induced by endothelin-1 (ET-1). Therefore, we evaluated its potential role in pruritus induced by ET-1.
Jiexian, Liang, Qing, Ji, Wenjin, Ji
openaire   +2 more sources

Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs

The Journal of Pharmacology and Experimental Therapeutics, 2012
We report the establishment of a new model for measuring gastric tone and liquid meal-induced accommodation in conscious guinea pigs and the role played by transient receptor potential ankyrin 1 (TRPA1). An indwelling polyethylene bag was placed in proximal stomachs of 5-week-old male Hartley guinea pigs. Gastric tone was measured by distending the bag
Junichi, Koseki, Tadayuki, Oshima, Takashi, Kondo, Toshihiko, Tomita, Hirokazu, Fukui, Jiro, Watari, Tomohisa, Hattori, Yoshio, Kase, Hiroto, Miwa   +8 more
openaire   +2 more sources

Transient Receptor Potential Ankyrin 1 in Diabetes

2019
Diabetic neuropathy (DN) is a common complication of diabetes, which is often associ-ated with a loss of peripheral sensitivity, but pain is also a common symptom and early manifestation of DN. Detailed mechanisms responsible for the neuropathy and the painful symptoms in diabetes are unknown.
openaire   +1 more source

Expression and distribution of the transient receptor potential cationic channel ankyrin 1 (TRPA1) in the human seminal vesicles

Health Science Reports, 2023
Stefan Uckert
exaly  

Activation of Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Channels Promotes Odontogenic Differentiation of Human Dental Pulp Cells

Journal of Endodontics, 2021
Na Xu, Kehua Que
exaly  

Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats

International Urogynecology Journal, 2022
Natsuho Hayashi, N. Kawamorita, Y. Ishizuka, Shingo Kimura, Y. Satake, A. Ito   +5 more
semanticscholar   +1 more source

Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015–2019)

Expert Opinion on Therapeutic Patents, 2020
Huifen Chen, Jack Terrett
exaly