mSphere, 2023 Transient receptor potential (TRP) channels are evolutionarily conserved integral membrane proteins. They serve as crucial mediators of sensory signals and have profound effects on cellular functions.
Hongchen Wang +3 more
doaj +2 more sources
Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells. [PDF]
PLoS ONE, 2017 Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3).
Shadia Omar +10 more
doaj +11 more sources
Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition [PDF]
Journal of Lipid ResearchAdipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel ...
Yu Fu +7 more
doaj +2 more sources
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function [PDF]
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
doaj +2 more sources
Transient Receptor Potential Channel 4 Small-Molecule Inhibition Alleviates Migraine-Like Behavior in Mice [PDF]
Frontiers in Molecular Neuroscience, 2021 Migraine is a common neurological disorder with few available treatment options. Recently, we have demonstrated the role of transient receptor potential cation channel subfamily C member 4 (TRPC4) in itch and the modulation of the calcitonin gene-related
Cinder Faith Cohen +5 more
doaj +2 more sources
The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature [PDF]
Frontiers in Immunology, 2017 Canonical or classical transient receptor potential channel 6 (TRPC6) is a Ca2+-permeable non-selective cation channel that is widely expressed in the heart, lung, and vascular tissues.
Monika Malczyk +8 more
doaj +2 more sources
Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel. [PDF]
PLoS Negl Trop Dis, 2021 Chulkov EG +8 more
europepmc +3 more sources
Transient receptor potential channel 6 in human skeletal muscle fibers: Investigation in fresh and conserved tissue samples. [PDF]
Biomed Rep, 2022 Servello D +3 more
europepmc +3 more sources
Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts [PDF]
Cardiology Journal, 2020 BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn +12 more
doaj +2 more sources
Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function [PDF]
Biochemistry and Biophysics Reports, 2019 While changes in intracellular calcium levels is a central step in platelet activation and thrombus formation, the contribution and mechanism of receptor-operated calcium entry (ROCE) via transient receptor potential channels (TRPCs) in platelets remains
Enma V. Paez Espinosa +4 more
doaj +2 more sources