Function of Transient Receptor Potential-Like Channel in Insect Egg Laying
Frontiers in Molecular Neuroscience, 2022 The transient receptor potential-like channel (TRPL) is a member of the transient receptor potential (TRP) channel family involved in regulating many fundamental senses, such as vision, pain, taste, and touch, in both invertebrates and vertebrates.
Yan Zhang +7 more
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Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]
, 2006 The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD +8 more
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TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]
, 2020 Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
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Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]
, 2016 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T. +9 more
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Structural insights into TRPV2 activation by small molecules
Nature Communications, 2022 A non-selective calcium channel transient receptor potential vanilloid 2 (TRPV2) is a potential drug target. Here, the authors employ cryo-electron microscopy, in silico docking, and electrophysiology to identify a binding site for an activator 2 ...
Ruth A. Pumroy +11 more
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Critical role of canonical transient receptor potential channel 7 in initiation of seizures [PDF]
, 2014 Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States.
Abramowitz, J. +4 more
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Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]
PLoS ONE, 2015 Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard +8 more
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Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities
Biomolecules, 2022 Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation.
Hong-Yu Liang +6 more
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Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]
, 2012 The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu +5 more
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Transient receptor potential melastatin 1: a hair cell transduction channel candidate. [PDF]
PLoS ONE, 2013 Sound and head movements are perceived through sensory hair cells in the inner ear. Mounting evidence indicates that this process is initiated by the opening of mechanically sensitive calcium-permeable channels, also referred to as the mechanoelectrical ...
John Gerka-Stuyt +3 more
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