Results 31 to 40 of about 243,028 (200)

Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The
Kun Ding, Kun Ding, Yang Gui, Yang Gui, Xu Hou, Xu Hou, Lifang Ye, Lihong Wang   +7 more
doaj   +1 more source

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges

Frontiers in Pharmacology, 2019
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily.
Zhen Wang, Zhen Wang, Zhen Wang, Di Ye, Di Ye, Di Ye, Jing Ye, Jing Ye, Jing Ye, Menglong Wang, Menglong Wang, Menglong Wang, Jianfang Liu, Jianfang Liu, Jianfang Liu, Huimin Jiang, Huimin Jiang, Huimin Jiang, Yao Xu, Yao Xu, Yao Xu, Jishou Zhang, Jiangbin Chen, Jun Wan, Jun Wan, Jun Wan   +25 more
doaj   +1 more source

Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii

Biology Open, 2020
Pungent substances, such as capsaicin and gingerol, activate the transient receptor potential (TRP)-V1 channel and affect the feeding behaviors of animals.
Mamoru Wada, Itaru Kaizuka, Kenjiro Yoshimura   +2 more
doaj   +1 more source

Structure of the full-length TRPV2 channel by cryo-EM. [PDF]

, 2016
Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R, Huynh, Kevin W, Jiang, Jiansen, Lodowski, David T, Moiseenkova-Bell, Vera Y, Samanta, Amrita, Zhou, Z Hong   +6 more
core   +2 more sources

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]

, 2017
Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts, Johnson, Philip Lee, Kunkler, Phillip Edward, Oxford, Gerry Stephen, Zhang, LuJuan   +4 more
core   +1 more source

Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Frontiers in Pharmacology, 2019
Changes of cholesterol level in the plasma membrane of cells have been shown to modulate ion channel function. The proposed mechanisms underlying these modulations include association of cholesterol to a single binding site at a single channel ...
Rita Gutorov, Maximilian Peters, Ben Katz, Tal Brandwine, Nicolas A. Barbera, Irena Levitan, Baruch Minke   +6 more
doaj   +1 more source

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. [PDF]

, 2017
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety ...
Yang, Fan, Zheng, Jie
core   +2 more sources

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation

FEBS Open Bio, 2017
Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but ...
Takahiro Shimizu, Taiga Higuchi, Toshihiro Toba, Chie Ohno, Takuto Fujii, Bernd Nilius, Hideki Sakai   +6 more
doaj   +1 more source

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source