Results 151 to 160 of about 19,126 (203)

Interactive segmentation of membrane and membrane‐mimic densities in cryo‐EM maps

Acta Crystallographica Section D, Volume 82, Issue 8, Page 848-861, August 2026.
SURFER performs automated segmentation of contextual membrane and membrane‐mimic density in cryo‐EM maps to enable robust separation of macromolecular signal from surrounding detergent or lipid–membrane features. It is conveniently distributed as a plugin for UCSF ChimeraX, allowing interactive application within standard map‐visualization workflows ...
Alok Bharadwaj, Lotte Veerbeek, Arjen Jakobi   +2 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

A Dialogic Participatory Model Between Professionals and Patients for the Co‐Creation of Transitioning Care Management Programmes in Rare Bone Diseases

Health Expectations, Volume 29, Issue 4, August 2026.
ABSTRACT Introduction Rare diseases are a group of heterogeneous conditions affecting fewer than 5 per 10,000 individuals in Europe, with rare bone diseases representing a clinically significant subgroup. Multiple osteochondromas, Ollier disease and Maffucci syndrome are multifocal benign rare disorders, characterised by bone deformities, functional ...
Marina Mordenti, Silvia Forni, Eleonora Grippa, Maria Cecilia la Forgia, Davide Scognamiglio, Manila Boarini, Gabriella Massa, Andrea Romeo, Alessandro Sergi, Luca Sangiorgi, Transitioning Care Management Working Group (TCM WG), Giovanni Beltrami, Domenico Campanacci, Nunzio Catena, Mauro Celli, Marta Cervo, Leonardo D'Agruma, Gian Luigi Federico, Giovanni Gallone, Michela Veronika Gonfiantini, Laura Masi, Maria Beatrice Michelis, Osvaldo Palmacci, Annabruna Ronchetti, Paolo Trezza   +24 more
wiley   +1 more source

Neuronal transient receptor potential (TRP) channels and noxious sensory detection in sickle cell disease. [PDF]

Neurosci Lett, 2019
Sadler KE, Stucky CL.
europepmc   +1 more source

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

Transient receptor potential (TRP) cation channels

British Journal of Pharmacology, 2009
openaire   +2 more sources

The Role of Photobiomodulation and Light Therapy in Enhancing Burn Wound Recovery

Journal of Cosmetic Dermatology, Volume 25, Issue 8, August 2026.
ABSTRACT Background Photobiomodulation (PBM) is a non‐invasive treatment using low‐intensity red or near‐infrared light to stimulate tissue repair and reduce inflammation. While used in aesthetic and rehabilitative medicine, its role in burn wound healing remains underexplored.
Edwin Chrabieh, Mahmoud El Hajj, Saif Emsieh, Hazem Omaish, Mazen Kurban   +4 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1543-1549, August 2026.
We investigated the effects of combined transcranial direct current stimulation (tDCS) and oral capsaicinoids on swallowing function in 21 healthy young adults. The combined cortical and peripheral sensory intervention could potentially facilitate swallowing.
Ivy Cheng, Sonja Suntrup‐Krüger
wiley   +1 more source

Physiological mechanisms and therapeutic targets in chronic cough

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown, Katherine L. Rhatigan, Oliver J. Price, Peter S. P. Cho   +3 more
wiley   +1 more source