Results 31 to 40 of about 11,254,715 (215)
Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]
, 2012 TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner +35 more
core +2 more sources
Role of Chemosensory TRP Channels in Lung Cancer
Pharmaceuticals, 2018 Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances.
Thomas R. H. Büch +4 more
doaj +1 more source
TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Cells, 2021 The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modulated
Trine L. Toft-Bertelsen, Nanna MacAulay
doaj +1 more source
Targeting TRP Channels for Pain, Itch and Neurogenic Inflammation
, 2023 Transient receptor potential (TRP) channels are multifunctional signaling molecules with important roles in health and disease [...
Arpad Szallasi, Ari-Pekka Koivisto
core +1 more source
Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
core +2 more sources
Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.
PLoS ONE, 2023 Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events.
Manae Tatsumi +8 more
doaj +1 more source
Transient Receptor Potential Channels and Inflammatory Bowel Disease
Frontiers in Immunology, 2020 The transient receptor potential (TRP) cation channels are present in abundance across the gastrointestinal (GI) tract, serving as detectors for a variety of stimuli and secondary transducers for G-protein coupled receptors.
Yiding Chen +8 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Transient receptor potential (TRP) channels are one primary type of calcium (Ca2+) permeable channels, and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular ...
Tiecheng Zhong +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 BackgroundTransient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes.
Ishak Suat Ovey +7 more
doaj +1 more source
Patients with neurotrophic keratitis demonstrate alterations in ocular surface expression of transient receptor potential (TRP) channels [PDF]
, 2023 Neurotrophic keratopathy (NK), a rare corneal disease caused by trigeminal nerve damage, leads to impaired corneal sensitivity, blinking and tear reflexes, and corneal epithelium breakdown with poor healing, which may progress to corneal ulcer, melting ...
Marta Sacchetti +8 more
core +1 more source