Results 21 to 30 of about 19,126 (203)

Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Heart failure (HF) remains the leading cause of death, morbidity, and medical expenses worldwide. Treatments for HF with reduced ejection fraction have progressed in recent years; however, acute decompensated heart failure remains difficult to treat. The
Kun Ding, Kun Ding, Yang Gui, Yang Gui, Xu Hou, Xu Hou, Lifang Ye, Lihong Wang   +7 more
doaj   +1 more source

Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients

Frontiers in Pharmacology, 2022
In recent years, activation of thermal transient receptor potential (TRP) ion channels at a range of temperatures has received widespread attention as a target for traditional Chinese medicine (TCM) to regulate body temperature and relieve pain ...
Shidu Yan, Shidu Yan, Shidu Yan, Yuchan Huang, Yuchan Huang, Yuchan Huang, Qian Xiao, Qian Xiao, Qian Xiao, Zixia Su, Zixia Su, Zixia Su, Lei Xia, Lei Xia, Lei Xia, Jinling Xie, Jinling Xie, Jinling Xie, Fan Zhang, Fan Zhang, Fan Zhang, Zhengcai Du, Zhengcai Du, Zhengcai Du, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao   +32 more
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Multimodal roles of transient receptor potential channel activation in inducing pathological tissue scarification

Frontiers in Immunology, 2023
Transient receptor potential (TRP) channels are a class of transmembrane proteins that can sense a variety of physical/chemical stimuli, participate in the pathological processes of various diseases and have attracted increasing attention from ...
Yuping Zheng, Qingrui Huang, Yanfeng Zhang, Lanxin Geng, Wuqing Wang, Huimin Zhang, Xiang He, Qiannan Li   +7 more
doaj   +1 more source

TRP channels: Role in neurodegenerative diseases and therapeutic targets

Heliyon, 2023
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM,
Mashoque Ahmad Rather, Andleeb Khan, Lianchun Wang, Sadaf Jahan, Muneeb U. Rehman, Hafiz A. Makeen, Syam Mohan   +6 more
doaj   +1 more source

The Role of Transient Receptor Potential (TRP) Channels in the Transduction of Dental Pain. [PDF]

Int J Mol Sci, 2019
Dental pain is a common health problem that negatively impacts the activities of daily living. Dentine hypersensitivity and pulpitis-associated pain are among the most common types of dental pain. Patients with these conditions feel pain upon exposure of the affected tooth to various external stimuli. However, the molecular mechanisms underlying dental
Hossain MZ, Bakri MM, Yahya F, Ando H, Unno S, Kitagawa J.   +5 more
europepmc   +5 more sources

Transient Receptor Potential Channels in Cardiovascular and Renal Diseases

Cells, 2022
Transient receptor potential (TRP) channels belong to a superfamily of integral membrane proteins with diverse functions in sensory perception and cellular physiology [...]
Shuangtao Ma, Michael X. Zhu
doaj   +1 more source

Role of transient receptor potential (TRP) channels in osteoarthritis: a comprehensive review. [PDF]

Front Pharmacol
Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degeneration of articular cartilage, synovial inflammation, and persistent pain, which severely impairs the quality of life for hundreds of millions of patients worldwide.
Qiao P, Wang W, Liu S, Yang Y, Wang P, Liu Y, Su Y, Hu P, Pan J, Zhang L.   +9 more
europepmc   +4 more sources

Emerging role of transient receptor potential (TRP) channels in cancer progression. [PDF]

BMB Rep, 2020
Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors.
Yang D, Kim J.
europepmc   +4 more sources

Role of Chemosensory TRP Channels in Lung Cancer

Pharmaceuticals, 2018
Transient receptor potential (TRP) channels represent a large family of cation channels and many members of the TRP family have been shown to act as polymodal receptor molecules for irritative or potentially harmful substances.
Thomas R. H. Büch, Eva A. M. Büch, Ingrid Boekhoff, Dirk Steinritz, Achim Aigner   +4 more
doaj   +1 more source

Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels.

PLoS ONE, 2023
Transient receptor potential (TRP) channels are activated by various extracellular and intracellular stimuli and are involved in many physiological events.
Manae Tatsumi, Takayuki Kishi, Satoru Ishida, Hiroki Kawana, Akiharu Uwamizu, Yuki Ono, Kouki Kawakami, Junken Aoki, Asuka Inoue   +8 more
doaj   +1 more source